Results 11 to 20 of about 380,916 (120)

Vorinostat in the acute neuroinflammatory form of X‐linked adrenoleukodystrophy

Annals of Clinical and Translational Neurology, 2020
Objective To identify a pharmacological compound targeting macrophages, the most affected immune cells in inflammatory X‐linked adrenoleukodystrophy (cerebral X‐ALD) caused by ABCD1 mutations and involved in the success of hematopoietic stem cell ...
Bettina Zierfuss, Isabelle Weinhofer, Jörn‐Sven Kühl, Wolfgang Köhler, Annette Bley, Katharina Zauner, Johannes Binder, Ksenija Martinović, Christian Seiser, Christoph Hertzberg, Stephan Kemp, Gerda Egger, Gerda Leitner, Jan Bauer, Christoph Wiesinger, Markus Kunze, Sonja Forss‐Petter, Johannes Berger   +17 more
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Increased age and male sex are independently associated with higher frequency of blood–cerebrospinal fluid barrier dysfunction using the albumin quotient

Fluids and Barriers of the CNS, 2020
Background The cerebrospinal fluid (CSF)/serum quotient of albumin (QAlb) is the most used biomarker for the evaluation of blood–cerebrospinal fluid barrier (B-CSF-B) permeability.
Massimiliano Castellazzi, Andrea Morotti, Carmine Tamborino, Francesca Alessi, Silvy Pilotto, Eleonora Baldi, Luisa M. Caniatti, Alessandro Trentini, Ilaria Casetta, Enrico Granieri, Maura Pugliatti, Enrico Fainardi, Tiziana Bellini   +12 more
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Brain Ischemia Significantly Alters microRNA Expression in Human Peripheral Blood Natural Killer Cells

Frontiers in Immunology, 2020
Brain ischemia induces systemic immunosuppression and increases a host's susceptibility to infection. MicroRNAs (miRNAs) are molecular switches in immune cells, but the alterations of miRNAs in human immune cells in response to brain ischemia and their ...
Ying Kong, Ying Kong, Shiyao Li, Shiyao Li, Xiaojing Cheng, Xiaojing Cheng, Honglei Ren, Honglei Ren, Honglei Ren, Bohao Zhang, Hongshan Ma, Minshu Li, Minshu Li, Xiao-An Zhang   +13 more
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Viral vectors in neurodegenerative diseases: immune responses and therapeutic applications

Frontiers in Neurology
Gene transfer-based therapies utilizing viral vectors have undergone remarkable advancements and hold significant promise in addressing neurodegenerative diseases in recent years, whose potential mechanisms include replacing or silencing pathogenic genes
Yifei Wang, Yifei Wang, Yifei Wang, Siyu Mu, Siyu Mu, Siyu Mu, Fangxi Liu, Fangxi Liu, Fangxi Liu   +8 more
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Targeting foam cell formation in inflammatory brain diseases by the histone modifier MS‐275

Annals of Clinical and Translational Neurology, 2020
Objective To assess class I‐histone deacetylase (HDAC) inhibition on formation of lipid‐accumulating, disease‐promoting phagocytes upon myelin load in vitro, relevant for neuroinflammatory disorders like multiple sclerosis (MS) and cerebral X‐linked ...
Bettina Zierfuss, Isabelle Weinhofer, Agnieszka Buda, Niko Popitsch, Lena Hess, Verena Moos, Simon Hametner, Stephan Kemp, Wolfgang Köhler, Sonja Forss‐Petter, Christian Seiser, Johannes Berger   +11 more
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Repopulation of microglia and its implications for CNS disorders: Insights from the single-cell era

Neurobiology of Disease
Microglia, as resident macrophages in the central nervous system (CNS), have been the focus of the scientific community. The pace of exploration in the origin and development of microglia, though tortuous, never stops.
Cong Chen, Guanjia Qiao, Dantong Tang, Fengling Xu, Jiawen Dong, Jinpan Zhang, Boru Jin   +6 more
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Clinical manifestations of nervous system impairments in diabetes mellitus

Медицинский совет, 2018
Diabetes mellitus is one of the frequent diseases. The article describes diabetic neuropathy as the actual problem of modern neurology. It also provides the classification of central and peripheral nervous system impairments in diabetes mellitus and ...
N. V. Pizova
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Study on differential gene expression profile of serum exosomes in patients with acute cerebral infarction

Digital Chinese Medicine, 2021
Objective: To analyze the differential gene expression profile of serum exosomes in patients with acute cerebral infarction (ACI) and clarify the changes in gene expression related to cerebral infarction injury and the potential serum markers.
Tang Rongmei, Chen Bowei, Yi Jian, Liu Baiyan, Lin Huashan   +4 more
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Diagnostic value of exosomal miR-1246 for Parkinson’s disease [PDF]

Xin yixue
Objective To investigate the diagnostic value of exosomal miR-1246 for Parkinson’s disease （PD）. Methods Serum samples were collected from 30 PD patients （PD group） and 30 healthy controls （control group） receiving physical examination in the Second ...
WANG Xiaobei, YANG Shan, LI Yatan, YANG Xinling
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Adult-onset Leigh syndrome with recurrent seizures and peripheral neuropathy due to the 9176T > C mutation: a case report and literature review

BMC Neurology
Background Leigh syndrome (LS) is an inherited form of mitochondrial encephalopathy associated with various gene mutations of the oxidative phosphorylation system, typically occurring in infancy or early childhood and resulting in disability or even ...
Yashi Liao, Yaxin Lai, Xinxin Chen, Shanshan Zhao   +3 more
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