Results 11 to 20 of about 344,834 (282)

Management of disease-modifying treatments in neurological autoimmune diseases of the central nervous system [PDF]

Clinical and Experimental Immunology, 2013
Summary The therapeutic armamentarium for autoimmune diseases of the central nervous system, specifically multiple sclerosis and neuromyelitis optica, is steadily increasing, with a large spectrum of immunomodulatory and immunosuppressive agents targeting different mechanisms of the immune system.
Anke Salmen, Ralf Gold, Andrew Chan
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THE CENTRAL NERVOUS SYSTEM. Some Experimental Models of Neurological Diseases [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 1969
This monograph is the outgrowth of a course on the pathological physiology and anatomy of the central nervous system (CSN) given at the 1967 meeting of the International Academy of Pathology. The book follows the format of the course and is divided into three sections, discussing some experimental models of neurological diseases, geographic pathology ...
J. A. Simpson
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Neuroimmune crosstalk in the central nervous system and its significance for neurological diseases [PDF]

Journal of Neuroinflammation, 2012
The central nervous system (CNS) is now known to actively communicate with the immune system to control immune responses both centrally and peripherally. Within the CNS, while studies on glial cells, especially microglia, have highlighted the importance of this cell type in innate immune responses of the CNS, the immune regulatory functions of other ...
Li Tian, Li Ma, Tiina Kaarela, Zhilin Li
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Apoptosis in development and disease of the nervous system: II. Apoptosis in childhood neurologic disease

Pediatric Neurology, 1997
The loss of cells in the human nervous system has long been known as the hallmark of incurable degenerative disease. Recent studies that began with attempts to understand cell loss during normal development have now begun to contribute to our understanding of the process of pathological cell loss.
Harris A. Gelbard, Rose-Mary Boustany, Nina F. Schor   +2 more
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Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis [PDF]

Journal of Neuroinflammation, 2019
Development of central nervous system (CNS) is regulated by both intrinsic and peripheral signals. Previous studies have suggested that environmental factors affect neurological activities under both physiological and pathological conditions. Although there is anatomical separation, emerging evidence has indicated the existence of bidirectional ...
Qianquan Ma, Changsheng Xing, Wenyong Long, Helen Y. Wang, Qing Liu, Rong‐Fu Wang   +5 more
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Morpholine derivatives as potential agents for neurological manifestations of nervous system diseases [PDF]

Pharmacy Formulas, 2020
Diseases of the nervous system, especially those of vascular, traumatic, and neurodegenerative nature, are characterized by high prevalence, disability and mortality rates, and therefore have a particularly big medical and social impact. Currently, pharmacotherapy options for these diseases are limited to a relatively small number of clinically proven ...
V. A. Prikhodko, Yuriy I. Sysoev, Sergey V. Okovityi   +2 more
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Effects of Tocilizumab Therapy on Circulating B Cells and T Helper Cells in Patients With Neuromyelitis Optica Spectrum Disorder

Frontiers in Immunology, 2021
Tocilizumab, a humanized anti-IL-6 receptor monoclonal antibody, showed its therapeutic efficacy on neuromyelitis optica spectrum disorder (NMOSD).
Ye Liu, Huiming Zhang, Tian-Xiang Zhang, Meng Yuan, Chen Du, Pei Zeng, Zhenning Huang, Dongmei Jia, Guili Yang, Fu-Dong Shi, Fu-Dong Shi, Chao Zhang, Chao Zhang   +12 more
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IgG-index predicts neurological morbidity in patients with infectious central nervous system diseases [PDF]

BMC Infectious Diseases, 2010
Prognosis assessment of patients with infectious and neoplastic disorders of the central nervous system (CNS) may still pose a challenge. In this retrospective cross-sectional study the prognostic value of basic cerebrospinal fluid (CSF) parameters in patients with bacterial meningitis, viral meningoencephalitis and leptomeningeal metastases were ...
Peter Lackner, Elif Guengoer, Ronny Beer, Gregor Broessner, Raimund Helbok, Florian Deisenhammer, Erich Schmutzhard, Bettina Pfausler   +7 more
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MicroRNAs: Key Regulators in the Central Nervous System and Their Implication in Neurological Diseases [PDF]

International Journal of Molecular Sciences, 2016
MicroRNAs (miRNAs) are a class of small, well-conserved noncoding RNAs that regulate gene expression post-transcriptionally. They have been demonstrated to regulate a lot of biological pathways and cellular functions. Many miRNAs are dynamically regulated during central nervous system (CNS) development and are spatially expressed in adult brain ...
Dandan Cao, Lu Li, Wai‐Yee Chan
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Peroxisomal very long-chain fatty acid transport is targeted by herpesviruses and the antiviral host response

Communications Biology, 2022
Using Epstein-Barr virus (EBV) infection of human B cells, the importance of peroxisomal very long-chain fatty acid transport involving ABCD1 in viral infection and host defence is elucidated and applicable also to other herpes- and coronaviruses.
Isabelle Weinhofer, Agnieszka Buda, Markus Kunze, Zsofia Palfi, Matthäus Traunfellner, Sarah Hesse, Andrea Villoria-Gonzalez, Jörg Hofmann, Simon Hametner, Günther Regelsberger, Ann B. Moser, Florian Eichler, Stephan Kemp, Jan Bauer, Jörn-Sven Kühl, Sonja Forss-Petter, Johannes Berger   +16 more
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