Results 71 to 80 of about 527,553 (336)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

PERSPECTIVES OF THERAPY WITH CEREBROLYSIN IN NEUROLOGY AND ITS PLACE IN CLINICAL PRACTICE OF PEDIATRIC NEUROLOGY

Русский журнал детской неврологии, 2015
A detailed review of the literature, reflecting many aspects of сerebrolysin in a wide range of nervous system disorders, including various diseases in children is described.
A. S. Petrukhin, O. A. Pylaeva
doaj   +1 more source

Therapeutic decision making in autoimmune and inflammatory disorders of the central nervous system in children. [PDF]

, 2016
Autoimmune and inflammatory disorders of the central nervous system can result in significant morbidity and mortality. Through the recognition of syndromes using diagnostic biomarkers, the clinician is now able to use immune suppressive therapies to ...
Dale, Rc, Lim, M., Nosadini, M
core  

Neurologic manifestations in 1760 COVID-19 patients admitted to Papa Giovanni XXIII Hospital, Bergamo, Italy

Journal of Neurology, 2020
Evidences from either small series or spontaneous reporting are accumulating that SARS-CoV-2 involves the Nervous Systems. The aim of this study is to provide an extensive overview on the major neurological complications in a large cohort of COVID-19 ...
N. Rifino, B. Censori, E. Agazzi, D. Alimonti, V. Bonito, Giorgia Camera, M. Conti, C. Foresti, B. Frigeni, S. Gerevini, M. Grimoldi, S. La Gioia, T. Partziguian, S. Quadri, R. Riva, M. C. Servalli, M. Sgarzi, Benedetta Storti, M. Vedovello, E. Venturelli, M. Vigano’, A. Callegaro, M. Arosio, M. Sessa   +23 more
semanticscholar   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Differential expression profiles of lncRNAs and a preliminary study on the mechanism of lncRNA FAM225A in triple seronegative myasthenia gravis

Frontiers in Immunology
BackgroundTriple-seronegative (Triple-SN) myasthenia gravis (MG) is a subtype of MG, and its diagnosis and treatment are challenging. Our study aims to discover new biomarkers and potential therapeutic targets and explore the preliminary mechanisms of ...
Yuehan Hao, Yuehan Hao, Yuehan Hao, Chen Chen, Bo Wang, Bo Wang, Bo Wang, ChunHua Yang, Ying Zhu, Ying Zhu, Ying Zhu, Ruixia Zhu, Ruixia Zhu, Ruixia Zhu   +13 more
doaj   +1 more source

Publication trends of neurology articles in a biomedical journal from India

Annals of Indian Academy of Neurology, 2012
Background: The details about the research productivity in the neurology specialty from India is lacking. We analyzed the publishing trends and the research productivity of neurology-related articles in the Journal of the Association of Physicians of ...
K. V. S. Hari Kumar, K Aravinda
doaj   +1 more source

Doxycycline Induces Apoptosis of Brucella Suis S2 Strain-Infected HMC3 Microglial Cells by Activating Calreticulin-Dependent JNK/p53 Signaling Pathway

Frontiers in Cellular and Infection Microbiology, 2021
Neurobrucellosis is a chronic complication of human brucellosis that is caused by the presence of Brucella spp in the central nervous system (CNS) and the inflammation play a key role on the pathogenesis.
Zhao Wang, Yanbai Wang, Huan Yang, Jiayu Guo, Zhenhai Wang, Zhenhai Wang   +5 more
doaj   +1 more source

Matrix Metalloproteinase-9 and Inflammation in Different Types of Multiple Sclerosis [PDF]

, 2016
Different clinical courses of multiple sclerosis, heterogeneity of its clinical implications, different effect of immunomodulatory therapy for the same clinical forms implies various pathogenetic mechanisms of central nervous system damage at this ...
Chernenko, M. (Maksym), Nehreba, T. (Tatyana), Vasylovskyy, V. (Vitaliy), Voloshyna, N. (Nataliya), Vovk, V. (Viktoriya)   +4 more
core   +2 more sources

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source