Results 81 to 90 of about 7,807 (215)

Microfabrication Technologies for Nanoinvasive and High‐Resolution Magnetic Neuromodulation

Advanced Science
The increasing demand for precise neuromodulation necessitates advancements in techniques to achieve higher spatial resolution. Magnetic stimulation, offering low signal attenuation and minimal tissue damage, plays a significant role in neuromodulation ...
Changhao Ge, Tahereh Masalehdan, Mahdieh Shojaei Baghini, Vicente Duran Toro, Lorenzo Signorelli, Hannah Thomson, Danijela Gregurec, Hadi Heidari   +7 more
doaj   +1 more source

In Silico to In Cerebro—Development of the Orexin Receptor Antagonist “Photorexant” for Photomodulation In Vitro and in Mouse Brains

Angewandte Chemie International Edition, EarlyView.
Following a structure‐based design approach, photoswitchable derivatives of the FDA‐approved drug suvorexant were designed, docked, synthesized, and characterized pharmacologically at the orexin 1 and 2 receptors (OX1R and OX2R). Optimized “photorexant” showed up to an 11‐fold difference in IC50 between photoisomers, enabled dynamic and reversible ...
Marcus Angermann, Marie H. Deventer, Vicente Ledesma‐Martin, Nuno Martinho, Alix Flake, Silvia Mori, Angel Nuñez, Jaime Pignatelli, Rita C. Guedes, Christophe P. Stove, Michael Decker   +10 more
wiley   +1 more source

Parameter selection drives electrophysiological responses to adaptive deep brain stimulation in Parkinson’s disease

Brain Stimulation, 2023
Johannes Leon Busch, Jonathan Kaplan, Jeroen Habets, Lucia Feldmann, Jan Roediger, Richard Köhler, Timon Merk, Katharina Faust, Gerd-Helge Schneider, Wolf-Julian Neumann, Andrea Kühn   +10 more
doaj   +1 more source

A critical reappraisal of the carotid sinus and carotid bulb: Distinguishing neurohistological function from vascular geometry

The Anatomical Record, EarlyView.
This review redefines the carotid bulb (CB) as a variable geometric dilation shaped by hemodynamics and the carotid sinus (CS) as a conserved neurohistological baroreceptor field. Distinguishing these entities clarifies a century of anatomical confusion and links geometry, neurohistology, and clinical interpretation within a unified framework ...
Răzvan Costin Tudose, Nicolae Radu, Mugurel Constantin Rusu   +2 more
wiley   +1 more source

Neuromodulation guide for the non-neuromodulator clinician: What it is and how it can benefit patients?

Biomolecules & Biomedicine
Neuromodulation is being utilized across a variety of medical subspecialties to treat both painful and non-painful medical conditions. However, publications on neuromodulation topics infrequently occur in journals targeting generalists and medical ...
Chelsey Hoffmann, Jinlan Wang, Rushna P. Ali, Ryan S. D'Souza   +3 more
doaj   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Multi-night cortico-basal recordings reveal mechanisms of NREM slow-wave suppression and spontaneous awakenings in Parkinson’s disease

Nature Communications
Sleep disturbance is a prevalent and disabling comorbidity in Parkinson’s disease (PD). We performed multi-night (n = 57) at-home intracranial recordings from electrocorticography and subcortical electrodes using sensing-enabled Deep Brain Stimulation ...
Md Fahim Anjum, Clay Smyth, Rafael Zuzuárregui, Derk Jan Dijk, Philip A. Starr, Timothy Denison, Simon Little   +6 more
doaj   +1 more source

Reclaiming Anatomy as Method: From Morphological Reasoning to Clinical Relevance

Clinical Anatomy, EarlyView.
ABSTRACT In recent decades, molecular biology and omics technologies have profoundly reshaped biomedical research, with genomics, proteomics, and other high‐throughput approaches dominating scientific agendas and funding priorities. Within this molecular paradigm, however, the anatomical sciences face an epistemic and institutional tension: morphology,
Katia Cortese, Marco Frascio
wiley   +1 more source

Development of neuromodulation and localization research on implantable device

Chinese Journal of Contemporary Neurology and Neurosurgery, 2015
After over twenty years of clinical research and application, neuromodulation technology has significant efficacy and broad prospect in movement disorders, pain, epilepsy and psychiatric diseases.
Hong-wei HAO, Yuan YUAN, Lu-ming LI
doaj  

Brain-machine interactive neuromodulation research tool with edge AI computing

Heliyon
Closed-loop neuromodulation with intelligence methods has shown great potentials in providing novel neuro-technology for treating neurological and psychiatric diseases.
Yan Li, Yingnan Nie, Zhaoyu Quan, Han Zhang, Rui Song, Hao Feng, Xi Cheng, Wei Liu, Xinyi Geng, Xinwei Sun, Yanwei Fu, Shouyan Wang   +11 more
doaj   +1 more source