Studies on fazadinium bromide (AH 8165): A new non-depolarizing neuromuscular blocking agent [PDF]
, 1976 R. I. G. Hughes, J. P. Payne, N Sugai
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Nuclear Import Defects Drive Cell Cycle Dysregulation in Neurodegeneration
Aging Cell, EarlyView.Overview of Dysregulated Cell Cycle Mechanisms in Neuronal Cells. A nuclear import block drives cell cycle re‐entry from G0, culminating in cell cycle arrest at G1/S. This cell cycle arrest is associated with activation of CKIs from the INK locus (p15, p16, p18, p19) and Cip/Kip (p21, p27) which act on specific CDK/Cyclin complexes.
Jonathan Plessis‐Belair +3 more
wiley +1 more source
Prolonged use of neuromuscular blocking agents is associated with increased long-term mortality in mechanically ventilated medical ICU patients: a retrospective cohort study. [PDF]
J Intensive Care, 2023 Lin C +5 more
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Fatal drug overdoses in healthcare workers: A thematic framework analysis of coroner reports
Addiction, EarlyView.Abstract Background and aims Healthcare workers face specific vulnerabilities for drug overdose due to their unique access to medications, clinical knowledge and work‐related stress. This study aimed to understand the characteristics of fatal overdoses in healthcare workers with a view to providing guidance for preventative strategies.
Thikra Algahtani +6 more
wiley +1 more source
REVersal of nEuromusculAr bLocking Agents in Patients Undergoing General Anaesthesia (REVEAL Study). [PDF]
J Clin Med, 2023 Greco M +12 more
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AUTONOMIC/NEUROMUSCULAR DOSE-RATIOS AND HEMODYNAMIC EFFECTS OF BW785U, A SHORT-ACTING NONDEPOLARIZING ESTER NEUROMUSCULAR BLOCKING AGENT [PDF]
, 1979 William B. Wastila, John J. Savarese
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Alkalinised lidocaine as an anaesthetic before onabotulinumtoxinA injections. a randomised trial
BJU International, Volume 135, Issue 4, Page 638-647, April 2025.Objectives To evaluate the effect of intravesical alkalinised lidocaine as an anaesthetic treatment on procedural pain during intradetrusor onabotulinumtoxinA (BTX‐A) injections for overactive bladder. Patients and Methods This single‐centre, randomised, double‐blind, placebo‐controlled two period crossover trial was conducted on women scheduled for ...
Meryam El Issaoui +2 more
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General anesthesia using remimazolam and remifentanil in combination with local anesthetics without neuromuscular blocking agents in a patient with myotonic dystrophy. [PDF]
Korean J Anesthesiol, 2023 Koyama Y +4 more
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Synthetic microneurotrophins: Neurotrophin receptors for therapeutics of neurodegenerative diseases
British Journal of Pharmacology, EarlyView.Neurodegenerative disorders are characterised by the chronic progressive degeneration of specific neuronal subtypes, neuroinflammation, myelin damage and synaptic loss. Despite their growing incidence, advancements in effective treatments remain limited, because of lack of knowledge for the aetiology of the diverse pathophysiology to design systematic ...
Ioanna Zota +4 more
wiley +1 more source
Non‐canonical PKG1 regulation in cardiovascular health and disease
British Journal of Pharmacology, EarlyView.It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
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