Results 171 to 180 of about 5,990 (215)

Two new short-acting non-depolarizing neuromuscular blocking agents

Experientia, 1972
Le chlorure de 1,1′-octamethylene et le methylsulfate de 5,5′-octamethylenebis ont chez le chat un effet de blocage neuro-musculaire non depolarisant, de courte duree. Les comparaisons faites avec des analogues voisins suggerent que l'activite de ces composes est influencee par le degre d'empechement sterique autour des atomes d'azote quaternaire.
F C, Copp, G G, Coker, A F, Green, R, Hughes, R H, Nimmo-Smith   +4 more
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Depolarizing Neuromuscular Blocking Agents

2017
Succinylcholine was first introduced into clinical practice in the 1950s, and is currently the only depolarizing neuromuscular blocker in use. It is unique among the drugs used for muscle relaxation in its rapid onset and short duration of action. These characteristics account for its extensive use in scenarios requiring emergency control of the airway.
Caroline S. Gross, Zhiling Xiong
openaire   +1 more source

Clinical pharmacology of ORG 7617, a short-acting non-depolarizing neuromuscular blocking agent

European Journal of Clinical Pharmacology, 1994
The dose-response relationship and the time course of action of Org 7617, a short acting non-depolarizing neuromuscular blocking agent, were evaluated during thiopentone, fentanyl, halothane and N2O anaesthesia. Neuromuscular transmission was monitored mechanomyographically. The ED50 and ED90 were calculated after single bolus doses of the drug. Twelve,
van den Broek, L, Wierda, JMKH, PROOST, JH, Hommes, FDM, Agoston, S   +4 more
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Increased Sensitivity to Depolarizing and Nondepolarizing Neuromuscular Blocking Agents in Young Rat Hemidiaphragms

Anesthesiology, 2001
Background Newborn neuromuscular junctions are more sensitive to d-tubocurarine than more mature preparations. It is unclear whether the same modifications occur with newer nondepolarizing agents and depolarizing agent succinylcholine.
L P, Fortier, R, Robitaille, F, Donati
openaire   +2 more sources

A study in vitro of new short-acting, non-depolarizing neuromuscular blocking agents

Biochemical Pharmacology, 1969
Abstract Presently available short-acting, depolarizing myoneural blocking agents have significant side effects such as increased intraocular tension, cardiac arrhythmias desensitization of the postjunctional membrane, skeletal muscle injury and muscle pains. Non-depolarizing blocking drugs do not produce profound blocks of short duration.
R J, Kitz, J H, Karis, S, Ginsburg
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Combining non-depolarizing neuromuscular blocking agents: synergism, addition or antagonism?

Current Opinion in Anaesthesiology, 1999
As the quality of currently available relaxants has improved, the need to combine relaxants to minimize the incidence and severity of their side-effects has decreased. Little work has been done in the past year characterizing the effects of combining different non-depolarizing neuromuscular blocking agents.
openaire   +2 more sources

Incubation Conditions and Reversibility of a New Non‐Depolarizing Neurornuscular Blocking Agent, Org‐NC45

Acta Anaesthesiologica Scandinavica, 1980
We describe the clinical use, for intubation purposes, of Org‐NC45, a new non‐depolarizing neuromuscular blocking agent. Administration of 50 and 72 μg/kg of this drug allowed good to excellent endotracheal intubation conditions within 3 and 2 min, respectively. In none of the cases was a signifcant change in blood pressure or heart rate seen after the
N, Krieg, L, Mazur, L H, Booij, J F, Crul   +3 more
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Interactions between ORG9426 and other non-depolarizing neuromuscular blocking agents in ratsin vivo

Journal of Anesthesia, 1992
In this study, combined neuromuscular blocking effects of ORG9426 with other non-depolarizing neuromuscular blocking agents were investigated. About 20% steady state neuromuscular block was established by a continuous infusion of one of 6 neuromuscular blocking agents (ORG9426, vecuronium, pancuronium, pipecuronium, d-tubocurarine and metocurine). Then
openaire   +2 more sources

Cardiac effects of non-depolarizing neuromuscular blocking agents pancuronium, vecuronium, and rocuronium in isolated rat atria

General Pharmacology: The Vascular System, 1999
Pancuronium, vecuronium, and rocuronium produce different cardiac effects. Using spontaneously beating right and electrically stimulated left rat atria, while measuring developed force, effective refractory period, and heart rate, we determined and compared the concentration-dependent cardiac effects of the compounds.
A L, Melnikov, K Y, Malakhov, K G, Helgesen, D A, Lathrop   +3 more
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Interactions of Volatile Anesthetics with Non-Depolarizing Neuromuscular Blocking Agents

1995
Drug interactions involving neuromuscular blocking agents are divided into two classes: one is interaction between neuromuscular blocking drugs and other classes of drug.The second is interactions with neuromuscular blocking agents each other.
openaire   +1 more source