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Sugammadex: clinical development and practical use [PDF]
Korean Journal of Anesthesiology, 2013 Sugammadex is belonging to a new class of drugs: the selective relaxant binding agents. Sugammadex can reverse residual paralysis by encapsulating free circulating non depolarizing muscle relaxants.
Thomas Fuchs-Buder +2 more
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Current clinical application of dantrolene sodium [PDF]
Anesthesia and Pain Medicine, 2023 Dantrolene sodium (DS) was first introduced as an oral antispasmodic drug. However, in 1975, DS was demonstrated to be effective for managing malignant hyperthermia (MH) and was adopted as the primary therapeutic drug after intravenous administration ...
Hong Seuk Yang +5 more
doaj +1 more source
Pharmacodynamic interactions between muscle relaxants and other medications in practice of anesthesia [PDF]
Farmacja Polska, 2023 Knowledge of drug interactions is an essential element of medical practice. Along with the increasing occurrence of multimorbidity and the associated multi-drug use, the number of possible combinations of preparations is constantly rising.
Paweł Radkowski, Rafał Marek Okoński
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Rocuronium-Sugammadex in Anesthesia for Electroconvulsive Therapy [PDF]
Psikiyatride Güncel Yaklaşımlar, 2016 Electroconvulsive therapy (ECT) is a form of treatment which is very effective in many psychiatric disorders. The administration of anesthesia plays a positive role in the success of ECT and improves the oxygenation of the body during the process ...
Nilay Tas, Esra Yancar Demir
doaj +1 more source
Animals, 2023 (1) Background: Pancuronium bromide is a neuromuscular blocker used for immobilizing crocodiles that can be reversed with neostigmine. A recommended drug dose has only been established for saltwater crocodiles (Crocodylus porosus), mostly based on trials
Lionel Schilliger +6 more
doaj +1 more source
Neuromuscular blockers and their reversal: have we finally found the on-off switches?
Ain Shams Journal of Anesthesiology, 2021 Background A nondepolarizing neuromuscular blocking agent (NMBA) with a succinylcholine-like quick onset and offset has been the holy grail of the science of neuromuscular blockade.
Shagun Bhatia Shah +3 more
doaj +1 more source
Function and distribution of three types of rectifying channel in rat spinal root myelinated axons [PDF]
, 1987 1. The nature, distribution and function of rectifying channels in rat spinal root myelinated axons has been assessed with selective blocking agents and a variety of intracellular and extracellular recording techniques. 2.
H Bostock +7 more
core +1 more source
BMC Anesthesiology, 2017 Sugammadex, a modified gamma-cyclodextrin, has changed clinical practice of neuromuscular reversal dramatically. With the introduction of this selective relaxant binding agent, rapid and reliable neuromuscular reversal from any depth of block became ...
Hajime Iwasaki +3 more
doaj +1 more source
Frontiers in Pharmacology, 2023 Background: Sugammadex is known to reverse neuromuscular blockade induced by non-depolarizing agents. In children, the recommended dose for reversal of moderate neuromuscular blockade is 2 mg/kg.
Sang-Hwan Ji +17 more
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INFLUENCE OF “PRIMING” ON THE POTENCY OF NON-DEPOLARIZING NEUROMUSCULAR BLOCKING AGENTS
British Journal of Anaesthesia, 1987 Dose-response curves have been constructed to determine the ED50 and ED95 (doses required to produce a 50% and a 95% block, respectively) following administration of a small "priming" dose of atracurium 50 micrograms kg-1, vecuronium 10 micrograms kg-1 or pancuronium 10 micrograms kg-1.
M M, Brady, R K, Mirakhur, F M, Gibson
openaire +2 more sources