Results 221 to 230 of about 91,692 (300)

Neuron-specific Agrin splicing by Nova RNA-binding proteins regulates conserved neuromuscular junction development in chordates. [PDF]

PLoS Biol
Hossain MF, Popsuj S, Vitrinel B, Kaplan NA, Stolfi A, Christiaen L, Ruggiu M.   +6 more
europepmc   +1 more source

Spaceflight and sport science: Physiological monitoring and countermeasures for the astronaut–athlete on Mars exploration missions

Experimental Physiology, EarlyView.
Abstract Long‐duration spaceflight impacts essentially every system in the human body, resulting in multisystem deconditioning that might impair the health and performance of crewmembers, particularly on long‐duration exploration missions to Mars. In this review, we apply the sport science model of athlete monitoring, testing and training to astronauts;
Luke DeVirgiliis, Nicholas J. Goode, Kurt W. McDowell, Kirk L. English, Robert Novo, Virina Botros, Ginika Agwu, Jessica M. Scott, Lori L. Ploutz‐Snyder   +8 more
wiley   +1 more source

AMPK regulates the maintenance and remodelling of the neuromuscular junction. [PDF]

Mol Metab
Ng SY, Mikhail AI, Mattina SR, Mohammed SA, Khan SK, Desjardins EM, Lim C, Phillips SM, Steinberg GR, Ljubicic V.   +9 more
europepmc   +1 more source

Exercise training to preserve vitality capacity in ageing

Experimental Physiology, EarlyView.
Abstract Ageing is an escalating global health issue, with the World Health Organization (WHO) reporting that one in six individuals will be 60 years or older by the year 2030. Therefore, understanding the mechanisms of complex biological ageing processes and associated healthcare challenges has become increasingly important.
Raymond Jones, Taylor L. Taylor, Robert T. Mankowski, Fitzgerald Dodds, Michael Hankes, Joanna Hobson, Yi Lin, Keith Saffold, Silvienne C. Sint Jago, McKenna A. Tharpe, Emily L. Zumbro, Anna Thalacker‐Mercer, Thomas W. Buford   +12 more
wiley   +1 more source

MBNL deficiency in motor neurons disrupts neuromuscular junction maintenance and gait coordination. [PDF]

Brain
Frison-Roche C, Demier CM, Cottin S, Lainé J, Arandel L, Halliez M, Lemaitre M, Lornage X, Strochlic L, Swanson MS, Martinat C, Messéant J, Furling D, Rau F.   +13 more
europepmc   +1 more source

Isometric training at longer muscle–tendon complex lengths: A potential countermeasure to impaired neuro‐muscle–tendon function during space travel

Experimental Physiology, EarlyView.
Abstract Manned space exploration to distant destinations, including Mars, continues to be an aspiration of humankind. Space travel does, however, present many challenges to the body, amongst which adaptation to microgravity is perhaps the largest. For instance, both short and long manned spaceflight missions have shown substantial deleterious effects ...
Gerard McMahon, Andy Sanderson, Hans Degens   +2 more
wiley   +1 more source

Dietary nitrate supplementation mitigates age-related changes at the neuromuscular junction in mice. [PDF]

J Physiol
Rossi M, Zuccarelli L, Brocca L, Sazzi C, Gissi C, Rossi P, Grassi B, Porcelli S, Bottinelli R, Pellegrino MA.   +9 more
europepmc   +1 more source

Microgravity‐induced changes in skeletal muscle and possible countermeasures: What we can learn from bed rest and human space studies

Experimental Physiology, EarlyView.
Abstract Despite exercise countermeasures to sustain health and performance in spaceflight, complete maintenance of muscle mass and functions in microgravity is still not possible for most astronauts. The principal cause of the limited effectiveness of existing exercise countermeasures is the difficulty in achieving full loading forces in space.
Alessandra Bosutti, Bergita Ganse, Nicola A. Maffiuletti, Rob C. I. Wüst, Gustav J. Strijkers, Andy Sanderson, Hans Degens   +6 more
wiley   +1 more source

Interaction between neuromuscular junction metabolic requirements in fragile X syndrome and glycogen storage disease models. [PDF]

Dis Model Mech
Gurijala A, Rushton E, Leahy SN, Nelson N, Tessier CR, Broadie K.   +5 more
europepmc   +1 more source

Redox‐regulated signalling of adaptations to contractile activity in skeletal muscle: Implications for age‐related muscle weakness

Experimental Physiology, EarlyView.
Abstract Skeletal muscle adaptation to contractile activity is modulated by redox signalling, primarily through reactive oxygen species (ROS) such as hydrogen peroxide (H2O2). Early research framed ROS as deleterious byproducts of exercise, but subsequent studies have established their roles as signalling molecules involved in mitochondrial biogenesis,
Malcolm J. Jackson
wiley   +1 more source