Results 211 to 220 of about 8,587 (262)

Development of the neuromuscular junction

Cell and Tissue Research, 2006
The differentiation of the neuromuscular junction is a multistep process requiring coordinated interactions between nerve terminals and muscle. Although innervation is not needed for muscle production, the formation of nerve-muscle contacts, intramuscular nerve branching, and neuronal survival require reciprocal signals from nerve and muscle to ...
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Watching the neuromuscular junction

Journal of Neurocytology, 2003
To understand how synapses form, it is important to be able to watch them as they form. Transgenic mice in which motor axons are indelibly labeled with the Green Fluorescent Protein (GFP) or one of its spectral variants (XFPs) provide a new way to image motor nerve terminals; when combined with contrasting stains for the postsynaptic membrane, both pre-
Jeff W, Lichtman, Joshua R, Sanes
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Neuromuscular junction disorders

2016
Diseases of the neuromuscular junction comprise a wide range of disorders. Antibodies, genetic mutations, specific drugs or toxins interfere with the number or function of one of the essential proteins that control signaling between the presynaptic nerve ending and the postsynaptic muscle membrane.
Jan, Verschuuren, Ellen, Strijbos, Angela, Vincent   +2 more
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Acetylcholinesterase in the neuromuscular junction

Chemico-Biological Interactions, 1999
New findings regarding acetylcholinesterase (AChE) in the neuromuscular junction (NMJ), obtained in the last decade, are briefly reviewed. AChE is highly concentrated in the NMJs of vertebrates. Its location remains stable after denervation in mature rat muscles but not in early postnatal muscles.
R, Gaspersic, B, Koritnik, N, Crne-Finderle, J, Sketelj   +3 more
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Neuromuscular junctional disorders

The Indian Journal of Pediatrics, 2008
Neuromuscular junctional disorders (NMJ) in children are distinct entity. They may be acquired or hereditary. They pose problem in diagnosis because of the higher occurrence of sero negative Myasthenia Gravis (MG) cases in children. The identity of MusK antibody positivity in a good percentage of sero negative cases further adds to problems in ...
A S, Girija, V V, Ashraf
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Neuromuscular junctions in the leech

Journal of Comparative Neurology, 1973
AbstractNeuromuscular junctions on leech body wall muscle have been described. Based on vesicle morphology, there are two types of junctions, (I) clear vesicle terminals, and (II) dense core vesicle terminals. Further, the dense core terminals are‐of two types, (1) small terminals which appear to directly innervate body wall muscle cells, and (2) large
B A, Yaksta-Sauerland, R E, Coggeshall
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Neuromuscular junction toxins

Disease-a-Month
The neuromuscular junction (NMJ) is highly susceptible to neurotoxins due to its lack of protective barriers like the blood-brain barrier. Over time, a wide range of natural toxins have evolved to target the NMJ, derived from animals, plants, and bacteria, alongside modern synthetic compounds developed for use in medicine, insecticides, and warfare ...
Matthew C, Randall, Ryan, Feldman
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Glycobiology of the neuromuscular junction

Journal of Neurocytology, 2003
Most molecules that are present at synapses are glycosylated with carbohydrates, and some carbohydrate structures are themselves uniquely synaptic in their localization. Thus, proteins or lipids at the synapse may bear distinct carbohydrates that alter their localization or function.
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Neuromuscular Junction Disordersa

2015
Abstract The neuromuscular junction (NMJ) is a critical component of the motor unit that is made up of the distal, unmyelinated nerve terminal, synaptic space, and end-plate region of the muscle fiber. Contraction of muscle fiber involves a coordinated series of steps that ultimately generates an action potential at the muscle end plate (
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Myasthenia and the neuromuscular junction

Current Opinion in Neurology, 2012
Myasthenic syndromes are distinct disorders at the neuromuscular junction, most often with well characterized autoimmune or genetic pathology. New aspects of the dysfunctions give insight into the normal neuromuscular function in addition to giving therapeutic clues and tailoring the therapy to the pathophysiology in individual patients.Patients with ...
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