Results 191 to 200 of about 91,692 (300)

Peripheral glia and neurons jointly regulate activity-induced synaptic remodeling at the <i>Drosophila</i> neuromuscular junction. [PDF]

Elife
Chang YC, Peng YJ, Lee JY, Wen A, Chang KT.   +4 more
europepmc   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Efficacy of Mitochondrial Transfer in Healing Toxin-Induced Damage to Neuromuscular Junction, an Empirical Study. [PDF]

Synapse
Deschenes MR, Rackley M, Fernandez S, Heidebrecht M, Hamilton K, Paez HG, Paez CR, Alway SE.   +7 more
europepmc   +1 more source

Glucagon‐like peptide‐1 receptor agonists and muscle strength changes in older adults: Risks beyond muscle mass reductions

British Journal of Pharmacology, EarlyView.
Abstract Gastric inhibitory polypeptide (GIP)/Glucagon‐like peptide‐1 (GLP‐1) receptor agonists are increasingly prescribed for the management of obesity and type 2 diabetes, yet research pertinent to their effects on muscle health is limited. Considering the central role of muscle strength as a sarcopenia component, this article summarizes emerging ...
Konstantinos Prokopidis
wiley   +1 more source

Neddylation E1 Obligatory Subunit Nae1 Is Critical to Neuromuscular Junction Development and Maintenance. [PDF]

J Neurosci
Jing H, Wu M, Xing G, Lin D, Chen P, Li L, Yu Z, Zhang H, Wang H, Su H, Xiong WC, Mei L.   +11 more
europepmc   +1 more source

Diaphragm‐specific effects of L‐citrulline in mdx mice highlight its potential as adjuvant of standard therapy in Duchenne muscular dystrophy

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose The absence of the protein dystrophin in Duchenne muscular dystrophy (DMD) leads to progressive muscle weakness, failing regeneration and deregulation of nitric oxide (NO) signalling. We focused on L‐citrulline, a precursor of L‐arginine, required for NO production in muscle, which is reduced in dystrophic mdx muscle ...
Lisamaura Tulimiero, Brigida Boccanegra, Paola Mantuano, Antonietta Mele, Michela De Bellis, Roberta Lenti, Francesca Sanarica, Santa Cirmi, Elena Conte, Ornella Cappellari, Amber E. Sherrard, Ardawna Green, Mira Srinivasa, Marta L. Fiorotto, Annamaria De Luca   +14 more
wiley   +1 more source

Activity-dependent muscarinic signalling regulates presynaptic PKC pathway and neurotransmission machinery at the neuromuscular junction. [PDF]

Cell Commun Signal
Polishchuk A, Just-Borràs L, Cilleros-Mañé V, Balanyà-Segura M, Silvera Simón C, Tomàs M, Jami El Hirchi M, Díaz-Wallach M, Hurtado E, Tomàs J, Lanuza MA.   +10 more
europepmc   +1 more source

Three‐year outcomes of repeated botulinum neurotoxin A injections to the lower extremities in young children with spastic cerebral palsy in GMFCS levels I to III

Developmental Medicine &Child Neurology, EarlyView.
In this study, we followed a group of children 2 to 6 years old with spastic cerebral palsy functioning in GMFCS levels I–III, over 3 years. Sixty‐five received BoNT‐A and 59 did not. Repeated BoNT‐A injections over 3 years were not associated with improvements in gross motor function or passive ankle dorsiflexion. Daily step counts, favouring the BoNT‐
Darcy Fehlings, Emma Bohn, Lauren Switzer, Charles H. Goldsmith, Unni Narayanan, Peter L. Rosenbaum, F. Virginia Wright, Gary Foster, CP‐BoNT‐A Study Group, Timothy Carey, Mark Mason, Ronit Mesterman   +11 more
wiley   +1 more source

Conductive MXene/adECM hydrogel promotes skeletal muscle regeneration and innervation through Ca²⁺ influx modulation and neuromuscular junction formation. [PDF]

J Nanobiotechnology
Jin M, Zhang Y, Liang W, Ao R, Zhou Y, Dang W, Wu H, Han M, Zhen Y, An Y.   +9 more
europepmc   +1 more source

Interventions for children with developmental coordination disorder: A scoping review

Developmental Medicine &Child Neurology, EarlyView.
This scoping review identified 13 differing categories of interventions delivered to children with developmental coordination disorder worldwide ranging from task oriented, motor skills training, and sensorimotor approaches to sports training approaches and health promotion, with motor performance mostly reported as outcome and similar effectiveness ...
Dorothee Jelsma, Zdenek Svoboda, Reza Abdollahipour, Miriam Palomo Nieto, Miguel Villa De Gregorio, Kamila Banatova, Farhad Ghadiri, Fatemeh Alaei, Paola Violasdotter Nilsson, Dido Green   +9 more
wiley   +1 more source