Results 191 to 200 of about 8,587 (262)

Neuromuscular junction transmission failure is a late phenotype in aging mice

, 2019
Deepti Chugh, Chitra C. Iyer, Xueyong Wang, Prameela Jyothi Bobbili, Mark M. Rich, W. David Arnold   +5 more
openalex   +2 more sources

Microgravity‐induced changes in skeletal muscle and possible countermeasures: What we can learn from bed rest and human space studies

Experimental Physiology, EarlyView.
Abstract Despite exercise countermeasures to sustain health and performance in spaceflight, complete maintenance of muscle mass and functions in microgravity is still not possible for most astronauts. The principal cause of the limited effectiveness of existing exercise countermeasures is the difficulty in achieving full loading forces in space.
Alessandra Bosutti, Bergita Ganse, Nicola A. Maffiuletti, Rob C. I. Wüst, Gustav J. Strijkers, Andy Sanderson, Hans Degens   +6 more
wiley   +1 more source

Redox‐regulated signalling of adaptations to contractile activity in skeletal muscle: Implications for age‐related muscle weakness

Experimental Physiology, EarlyView.
Abstract Skeletal muscle adaptation to contractile activity is modulated by redox signalling, primarily through reactive oxygen species (ROS) such as hydrogen peroxide (H2O2). Early research framed ROS as deleterious byproducts of exercise, but subsequent studies have established their roles as signalling molecules involved in mitochondrial biogenesis,
Malcolm J. Jackson
wiley   +1 more source

Passive thigh heating improves peak force production in younger adults and early isokinetic force production in younger and older adults

Experimental Physiology, EarlyView.
Abstract Older adults often suffer from reduced physical capability relative to young adults, in part due to impaired muscle function. This study investigated the ergogenic effects of passive thigh heating on knee extensor torque production in healthy older versus younger adults.
Desmond Denny, Daniel C. Low, Oliver R. Gibson   +2 more
wiley   +1 more source

Wnt/β-Catenin Signaling Suppresses Rapsyn Expression and Inhibits Acetylcholine Receptor Clustering at the Neuromuscular Junction

, 2008
Jia Wang, Nan-jie Ruan, Lei Qian, Wenliang Lei, Fei Chen, Zhen‐Ge Luo   +5 more
openalex   +1 more source

A multi‐omics investigation of sarcopenia and frailty: Integrating genomic, epigenomic and telomere length data

Experimental Physiology, EarlyView.
Abstract Sarcopenia and frailty are complex geriatric syndromes influenced by a combination of genetic and environmental factors. Recent studies suggest that specific genetic variants, DNA methylation patterns and shortened telomeres are associated with age‐related diseases and might contribute to the development of both sarcopenia and frailty. In this
Valentina Ginevičienė, Erinija Pranckevičienė, Alina Urnikytė, Laura Jurkūnaitė, Kristijona Gutauskaitė, Rūta Dadelienė, Justina Kilaitė, Ieva Eglė Jamontaitė, Asta Mastavičiūtė, Ildus I. Ahmetov, Vidmantas Alekna   +10 more
wiley   +1 more source

Additional file 16 of Syntaphilin loss enhances mitochondrial axonal transport and neuromuscular junction formation in a human stem cell derived neuromuscular assembloid model

Salzinger, Andrea, Özkan, Esra, Ramesh, Vidya, Nanda, Jyoti, Burr, Karen, Story, David, Pham, Nhan T., Chandran, Siddharthan, Selvaraj, Bhuvaneish T.   +8 more
openalex   +1 more source

Mitochondrial alterations as potential early events in neuromuscular junction remodelling with muscle disuse

Experimental Physiology, EarlyView.
Abstract Physical inactivity impairs neuromuscular health, promoting skeletal muscle atrophy, mitochondrial changes, and neuromuscular junction (NMJ) instability. However, the interplay between mitochondria and NMJ alterations in the context of muscle disuse remains underexplored.
Evgeniia Motanova, Evgenii Lysenko, Fabio Sarto, Mladen Gasparini, Boštjan Šimunic, Rado Pišot, Marco V. Narici   +6 more
wiley   +1 more source

Changes in motor unit conduction velocity after unilateral lower‐limb suspension and active recovery are correlated with muscle ion channel gene expression

Experimental Physiology, EarlyView.
Abstract The effects of muscle disuse on the propagation of action potentials along motor unit (MU) muscle fibres, a key process for effective muscle activation and force generation, remain poorly understood. The aim of this study was to investigate changes in action potential propagation and to identify biological factors influencing these changes ...
Giacomo Valli, Fabio Sarto, Francesco Negro, Elena Monti, Giuseppe Sirago, Matteo Paganini, Sandra Zampieri, Martino V. Franchi, Andrea Casolo, Julián Candia, Luigi Ferrucci, Marco V. Narici, Giuseppe De Vito   +12 more
wiley   +1 more source

Cerebral oxygenation and skeletal muscle responses to time trial, maximal oxygen uptake and time to exhaustion exercise

Experimental Physiology, EarlyView.
Abstract This study investigated cerebral and neuromuscular responses to three exercise models: time trial (TT), maximal oxygen uptake (V̇O2max${{\dot{V}}_{{{{\mathrm{O}}}_2}{\mathrm{max}}}}$) and time to exhaustion (TTE). Fourteen participants completed the tests in the following order: V̇O2max${{\dot{V}}_{{{{\mathrm{O}}}_2}{\mathrm{max}}}}$, TT and ...
Caroline V. Robertson, Nicole T. Vargas, Tegan Hartmann, Frank E. Marino   +3 more
wiley   +1 more source