Results 71 to 80 of about 615,784 (234)

Pathogenesis of myasthenia gravis: update on disease types, models, and mechanisms [version 1; referees: 2 approved]

F1000Research, 2016
Myasthenia gravis is an autoimmune disease of the neuromuscular junction (NMJ) caused by antibodies that attack components of the postsynaptic membrane, impair neuromuscular transmission, and lead to weakness and fatigue of skeletal muscle.
William D. Phillips, Angela Vincent
doaj   +1 more source

Cross‐disease comparison of amyotrophic lateral sclerosis and spinal muscular atrophy reveals conservation of selective vulnerability but differential neuromuscular junction pathology

The Journal of comparative neurology, 2015
Neuromuscular junctions are primary pathological targets in the lethal motor neuron diseases spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS).
L. Comley, Jik Nijssen, Johanna Frost-Nylén, E. Hedlund   +3 more
semanticscholar   +1 more source

EVIDENCE FOR RECYCLING OF SYNAPTIC VESICLE MEMBRANE DURING TRANSMITTER RELEASE AT THE FROG NEUROMUSCULAR JUNCTION

Journal of Cell Biology, 1973
When the nerves of isolated frog sartorius muscles were stimulated at 10 Hz, synaptic vesicles in the motor nerve terminals became transiently depleted.
J. Heuser, T. Reese
semanticscholar   +1 more source

Muscle specific kinase (MuSK) activation preserves neuromuscular junctions in the diaphragm but is not sufficient to provide a functional benefit in the SOD1G93A mouse model of ALS

Neurobiology of Disease, 2019
Amyotrophic lateral sclerosis (ALS), a neurodegenerative disease affecting motor neurons, is characterized by rapid decline of motor function and ultimately respiratory failure.
Arundhati Sengupta-Ghosh, Sara L. Dominguez, Luke Xie, Kai H. Barck, Zhiyu Jiang, Timothy Earr, Jose Imperio, Lilian Phu, Hanna G. Budayeva, Donald S. Kirkpatrick, Hao Cai, Jeffrey Eastham-Anderson, Hai Ngu, Oded Foreman, Maj Hedehus, Michael Reichelt, Isidro Hotzel, Yonglei Shang, Richard A.D. Carano, Gai Ayalon, Amy Easton   +20 more
doaj  

ALS as a distal axonopathy: molecular mechanisms affecting neuromuscular junction stability in the presymptomatic stages of the disease

Frontiers in Neuroscience, 2014
Amyotrophic Lateral Sclerosis (ALS) is being redefined as a distal axonopathy, in that many molecular changes influencing motor neuron degeneration occur at the neuromuscular junction (NMJ) at very early stages of the disease prior to symptom onset.
E. Moloney, F. de Winter, J. Verhaagen
semanticscholar   +1 more source

Simultaneous Combined Myositis, Inflammatory Polyneuropathy, and Overlap Myasthenic Syndrome

Case Reports in Neurological Medicine, 2016
Immune-mediated neuromuscular disorders include pathologies of the peripheral nervous system, neuromuscular junction, and muscles. If overlap syndromes (or the association of almost two autoimmune disorders) are recognized, the simultaneous occurrence of
Stéphane Mathis, Laurent Magy, Philippe Corcia, Karima Ghorab, Laurence Richard, Jonathan Ciron, Mathilde Duchesne, Jean-Michel Vallat   +7 more
doaj   +1 more source

The Neuromuscular Junction: Aging at the Crossroad between Nerves and Muscle

Frontiers in Aging Neuroscience, 2014
Aging is associated with a progressive loss of muscle mass and strength and a decline in neurophysiological functions. Age-related neuromuscular junction (NMJ) plays a key role in musculoskeletal impairment that occurs with aging.
M. Gonzalez-Freire, R. de Cabo, S. Studenski, L. Ferrucci   +3 more
semanticscholar   +1 more source

Dropped head syndrome due to neuromuscular disease: clinical manifestation and evaluation

Neurology International, 2019
In this article, we discuss the clinical approach to patients with dropped head syndrome and identify the various neuromuscular causes of dropped head syndrome, including muscle, neuromuscular junction, peripheral nerve, and motor neuron etiologies.
Ahmet Burakgazi, Perry Richardson, Mohammad Abu-Rub   +2 more
doaj   +1 more source

Skeletal muscle mTORC1 regulates neuromuscular junction stability

Journal of Cachexia, Sarcopenia and Muscle, 2020
Background Skeletal muscle is a plastic tissue that can adapt to different stimuli. It is well established that Mammalian Target of Rapamycin Complex 1 (mTORC1) signalling is a key modulator in mediating increases in skeletal muscle mass and function ...
Martina Baraldo, Alessia Geremia, Marco Pirazzini, Leonardo Nogara, Francesca Solagna, Clara Türk, Hendrik Nolte, Vanina Romanello, Aram Megighian, Simona Boncompagni, Marcus Kruger, Marco Sandri, Bert Blaauw   +12 more
doaj   +1 more source

Requirement of enhanced Survival Motoneuron protein imposed during neuromuscular junction maturation.

Journal of Clinical Investigation, 2014
Spinal muscular atrophy is a common motor neuron disease caused by low survival motoneuron (SMN), a key protein in the proper splicing of genes. Restoring the protein is therefore a promising therapeutic strategy. Implementation of this strategy, however,
S. Kariya, T. Obis, C. Garone, T. Akay, F. Sera, S. Iwata, S. Homma, U. Monani   +7 more
semanticscholar   +1 more source