Results 71 to 80 of about 13,660 (185)

Integrated Engineering of CAR‐T Cells for Solid Tumours

Cell Proliferation, EarlyView.
Solid tumours pose multifactorial barriers including antigen heterogeneity, immunosuppressive microenvironment, and poor T‐cell trafficking, limiting CAR‐T efficacy compared to hematologic malignancies. Integrated engineering strategies are essential, combining logic‐gated receptors for precision, metabolic‐epigenetic reprogramming for resilience, and ...
Chao Yang, Tan Li, Ping He, Zhijie Zhao, Shenglong Li, Liming Wang   +5 more
wiley   +1 more source

Neuromyelitis optica spectrum disorders in pediatric patients

Неврология, нейропсихиатрия, психосоматика, 2018
Neuromyelitis optica spectrum disorders (NMOSDs) is an inflammatory demyelinating disease of the central nervous system with a selective injury of the optic nerves and spinal cord.
Yu. V. Tokareva, A. S. Kotov, M. V. Panteleeva, M. S. Bunak   +3 more
doaj   +1 more source

Inborn errors of immunity in children with neuroinflammation

Developmental Medicine &Child Neurology, EarlyView.
Abstract Inborn errors of immunity (IEIs), an expanding group of monogenic disorders with diverse clinical manifestations, are increasingly recognized to include neuroinflammatory disease. Examples of diseases included under this umbrella are Aicardi–Goutières syndrome, deficiency of adenosine deaminase 2, familial haemophagocytic lymphohistiocytosis ...
Eppie M Yiu, Dilan Dissanayake, Jessie Cunningham, Helen Branson, Ori Scott, E Ann Yeh   +5 more
wiley   +1 more source

Simultaneous T2, T2*, and R2′ Mapping for Multiple Sclerosis Using Nonlinear Model‐Based Reconstruction of Undersampled Radial RARE‐EPI MRI

Magnetic Resonance in Medicine, Volume 96, Issue 4, Page 1872-1892, October 2026.
ABSTRACT Purpose To demonstrate the synergy of undersampled radial 2in1‐RARE‐EPI acquisition and nonlinear model‐based reconstruction for accelerated and simultaneous T2, T2*, and R2′ mapping in brains of patients with multiple sclerosis (MS). Methods 2in1‐RARE‐EPI combines a RARE module with an EPI module to capture T2 and T2* information.
Jose Raul Velasquez Vides, Carl J. J. Herrmann, Thomas Gladytz, Hoby P. Hetherington, Hendrik Mattern, Xiaoqing Wang, Jason M. Millward, Shahriar Shalikar, Igor Fabian Tellez Ceja, Beate Endemann, Sonia Waiczies, Joseph Kuchling, Friedemann Paul, Georg Rose, Min‐Chi Ku, Franz Schmitt, Thoralf Niendorf   +16 more
wiley   +1 more source

Clinical evaluation of rituximab treatment for neuromyelitis optica

Neurología (English Edition), 2015
Introduction: Neuromyelitis optica is an inflammatory and usually relapsing demyelinating autoimmune disease of the central nervous system that targets the optic nerves and spinal cord. Rituximab has been used for different neurological diseases that are
M.J. Fernández-Megía, B. Casanova-Estruch, F. Pérez-Miralles, J. Ruiz-Ramos, C. Alcalá-Vicente, J.L. Poveda-Andrés   +5 more
doaj   +1 more source

Possible Contribution of Multiple Sclerosis Pathology to Treatment‐Resistant Schizophrenia: A Case Study

Neuropsychopharmacology Reports, Volume 46, Issue 3, September 2026.
A case of multiple sclerosis detected by brain MRI during evaluation for modified electroconvulsive therapy in the long‐term course of schizophrenia. This case discusses the clinical overlap between multiple sclerosis pathology and treatment‐resistant schizophrenia. ABSTRACT Multiple sclerosis (MS) can present with neurological and psychiatric symptoms
Sho Miura, Atsuko Nagaoka, Mizuki Hino, Risa Shishido, Masataka Hatano, Yuto Hosogai, Kazusa Miyahara, Yuta Oba, Kimihiko Kaneko, Yasuto Kunii, Hiroaki Tomita   +10 more
wiley   +1 more source

Evaluación del uso de rituximab en la neuromielitis óptica

Neurología, 2015
Resumen: Introducción: La neuromielitis óptica es un trastorno autoinmune, inflamatorio y desmielinizante del sistema nervioso central que afecta a la médula espinal y al nervio óptico, de carácter recurrente.
M.J. Fernández-Megía, B. Casanova-Estruch, F. Pérez-Miralles, J. Ruiz-Ramos, C. Alcalá-Vicente, J.L. Poveda-Andrés   +5 more
doaj   +1 more source

Proteomic profile of CSF obtained at the time of diagnosis determines amyotrophic lateral sclerosis progression and survival: CXCL7 levels in disease prognosis and survival

Brain Pathology, Volume 36, Issue 5, September 2026.
Untargeted multiomic profiling of cerebrospinal fluid reveals that proteomic, but not lipidomic, signatures robustly distinguish ALS patients from controls and stratify individuals by survival, highlighting marked molecular differences between short survival and long survival disease.
Sergio Roca‐Pereira, Yaiza López‐Sampere, Pol Mengod‐Soler, Mario Peña‐Fonteboa, Carla Marco, Alejandro Caravaca‐Puchades, Raúl Domínguez, Juan Francisco Vázquez‐Costa, Enrique Santamaría, Joaquín Fernández‐Irigoyen, María J. Colomina, Isabel León Moreno, Antonio Martínez Yélamos, Sergio Martínez Yélamos, Gabriel Santpere, Elia Obis, Manuel Portero‐Otín, Gerard Piñol‐Ripoll, Mónica Povedano, Pol Andrés‐Benito   +19 more
wiley   +1 more source

Treatment of Neuromyelitis Optica

Japanese Journal of Clinical Immunology, 2012
Neuromyelitis optica (NMO) or Devic's disease is an inflammatory neurologic disease characterized by severe optic neuritis and transverse myelitis. Other features of NMO include female preponderance, higher onset age, severe functional disability, longitudinally extensive spinal cord lesions (longer than 3 vertebral segments), and oligoclonal IgG bands
openaire   +3 more sources

Therapeutic Apheresis for Intravenous Methylprednisolone‐Refractory Neuromyelitis Optica Spectrum Disorder: Clinical and Radiological Outcomes in a Single‐Center Case Series

Therapeutic Apheresis and Dialysis, Volume 30, Issue 4, Page 536-543, August 2026.
ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi, Daisuke Katagiri, Takeyuki Watadani, Shunichi Matsuda, Hiroshi Kaneko, Noritoshi Arai   +5 more
wiley   +1 more source