Results 81 to 90 of about 311,459 (229)

Hydrocephalus in neuromyelitis optica [PDF]

Neurology, 2014
A majority of patients with neuromyelitis optica (NMO) spectrum disorders (NMOSD) have MRI brain abnormalities, some of which are “NMO-typical” with localization in aquaporin 4 (AQP4)–rich circumventricular and periaqueductal regions.1 Although uncommon in adult patients, symptomatic brain involvement occurs in approximately 50% of NMO–immunoglobulin G
Stacey L, Clardy, Claudia F, Lucchinetti, Karl N, Krecke, Vanda A, Lennon, Orna, O'Toole, Brian G, Weinshenker, Clara D, Boyd, Stephen, Krieger, Corey, McGraw, Yong, Guo, Sean J, Pittock   +10 more
openaire   +2 more sources

Neuromyelitis optica MOG-IgG causes reversible lesions in mouse brain. [PDF]

, 2014
INTRODUCTION: Antibodies against myelin oligodendrocyte glycoprotein (MOG-IgG) are present in some neuromyelitis optica patients who lack antibodies against aquaporin-4 (AQP4-IgG). The effects of neuromyelitis optica MOG-IgG in the central nervous system
Owens, GP, Angela Vincent, Saadoun, S, Saadoun, Samira, Samira Saadoun, Jeffrey L Bennett, Vincent, A, Papadopoulos, MC, Bennett, JL, Marios C Papadopoulos, Patrick Waters, Gregory P Owens, Waters, P   +12 more
core   +2 more sources

Clinical, outcome and aetiological chacteristics of inflammatory optic neuropathies. A series of Algerian patients. [PDF]

Batna Journal of Medical Sciences
Introduction. Inflammatory optic neuropathies (ION) are frequent neuroophthalmological emergencies. They often pose an etiological problem. Objectives. To study the clinical, radiological, etiological and evolutionary particularities of ION in Algerian
Mohamed Islam KEDIHA, Dalila MOUALEK, Farida MOSTEFAOUI, Lamia ALI PACHA   +3 more
doaj   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Immunopathogenesis of Neuromyelitis Optica

, 2014
Neuromyelitis optica (NMO, Devic's syndrome) is a clinical syndrome characterized by optic neuritis and (mostly longitudinally extensive) myelitis. If untreated, NMO usually takes a relapsing course and often results in blindness and tetra- or paraparesis. The discovery of autoantibodies to aquaporin-4, the most abundant water channel in the CNS, in 70-
Levy, Michael, Wildemann, Brigitte, Jarius, Sven, Orellano, Benjamine, Sasidharan, Saranya, Weber, Martin S., Stuve, Olaf   +6 more
openaire   +3 more sources

Treatment of neuromyelitis optica/neuromyelitis optica spectrum disorders with methotrexate [PDF]

BMC Neurology, 2014
To review our experience using methotrexate as a single long-term immunosuppressant (IS) therapy in neuromyelitis optica/neuromyelitis optica spectrum disorders (NMO/NMOSD).We performed a retrospective chart review of all patients with a diagnosis of NMO/NMOSD, supported by a positive NMO-IgG testing, who were treated with methotrexate. A paired sample
Ramanathan, Ramnath Santosh, Malhotra, Konark, Scott, Thomas   +2 more
openaire   +2 more sources

Inborn errors of immunity in children with neuroinflammation

Developmental Medicine &Child Neurology, EarlyView.
Abstract Inborn errors of immunity (IEIs), an expanding group of monogenic disorders with diverse clinical manifestations, are increasingly recognized to include neuroinflammatory disease. Examples of diseases included under this umbrella are Aicardi–Goutières syndrome, deficiency of adenosine deaminase 2, familial haemophagocytic lymphohistiocytosis ...
Eppie M Yiu, Dilan Dissanayake, Jessie Cunningham, Helen Branson, Ori Scott, E Ann Yeh   +5 more
wiley   +1 more source

Management Strategies of Patients with Neuromyelitis Optica Spectrum Disorder During the COVID-19 Pandemic Era

, 2020
Sherif M Hamdy, Maged Abdel-Naseer, Hatem S Shehata, Nevin M Shalaby, Amr Hassan, Alaa Elmazny, Ehab Shaker, Mona AF Nada, Sandra M Ahmed, Mohamed I Hegazy, Husam S Mourad, Ahmed Abdelalim, Rehab Magdy, Alshimaa S Othman, Doaa A Mekkawy, Nirmeen A Kishk ...
Nada MAF, Elmazny A, Othman AS, Ahmed SM, Shehata HS, Hegazy MI, Mekkawy DA, Abdel-Naseer M, Abdelalim A, Shaker E, Shalaby NM, Kishk NA, Hassan A, Mourad HS, Hamdy SM, Magdy R   +15 more
core  

Neuromyelitis Optica and Neuromyelitis Optica Spectrum Disorder Patients in Turkish Cohort Demographic, Clinical, and Laboratory Features

, 2015
Background: Neuromyelitis optica (NMO) is an immune-mediated, chronic relapsing, inflammatory disease characterized by severe attacks of optic neuritis and ...
ALTINTAŞ, Azmi Ali, GÖKÇAY, FİGEN, Celik, Gokcen Gozubatik, TERZİ, MURAT, Nalbantoglu, Mecbure, Siva, Aksel, Isikay, Ilksen Colpak, Uygunoglu, Ugur, ÇELEBİSOY, NEŞE, Mangan, Mehmet Serhat, Balci, Belgin P., ÇELİK, YAHYA, Kurne, Aslä± Tuncer, Balca, Belgin P., Saip, Sabahattin, Soysal, Aysun, KARABUDAK, RANA, Kurne, Asli Tuncer, BOZ, CAVİT, YÜCESAN, CANAN, Isik, Nihal, Duman, Taskä±n, Diker, Sevda, Kansu, Tulay, Altintas, Ayse, Duman, Taskin   +25 more
core   +2 more sources