Results 81 to 90 of about 13,660 (185)

Pathology of neuromyelitis optica

Rinsho Shinkeigaku, 2009
Understanding of the pathogenesis of neuromyelitis optica (NMO) is rapidly growing. In our immunohistochemical studies from 2006, the loss of AQP4 was evident in about 90% of NMO lesions, especially in perivascular areas of acute inflammatory lesions where immunoglobulins and complements were deposited.
openaire   +3 more sources

Trends in Clinical Indications for Plasma Exchange in Adult Patients Between 2008 and 2024 in Bogotá, Colombia

Journal of Clinical Apheresis, Volume 41, Issue 4, August 2026.
ABSTRACT This multicenter retrospective study aimed to describe temporal trends in clinical indications for plasma exchange (PE) in adult patients at four quaternary‐care hospitals in Bogotá (2008–2024) and to examine their distribution across successive ASFA guideline editions.
Edgar Julián Reyes, Federico Tovar‐Avendaño, Camilo Alberto Gonzalez‐Gonzalez, Diana Carolina Vargas‐Angel, Jorge Pulido, Paula Violeta Rodríguez, Deiner‐Yivelson Muñoz‐Delgado, Kateir Contreras‐Villamizar   +7 more
wiley   +1 more source

Lack of Differences in the Pharmacokinetics of Therapeutic Monoclonal Antibodies Between Japanese and Non‐Japanese Individuals

The Journal of Clinical Pharmacology, Volume 66, Issue 8, August 2026.
Abstract Evaluation of the pharmacokinetics (PK) of new drugs in Japanese individuals is regularly requested by the Japanese regulatory agency prior to participation in global clinical trials or for bridging approaches for regulatory approval. However, the need for PK assessments in the Japanese population may be less compelling for monoclonal ...
Paridhi Gupta, Ashish Sharma, Bernd Meibohm   +2 more
wiley   +1 more source

Spatio‐Temporal Dynamics of Macroglial Cell Organization and Proximity to Blood Vessels During Postnatal Development

International Journal of Developmental Neuroscience, Volume 86, Issue 5, August 2026.
From P5, Sox9+ cells are evenly distributed, unlike Sox10+ cells. From P15, Sox9+ cells are located closer to blood vessels than Sox10+ cells. Distribution of astrocytes is not altered in Mlc1 KO cortex. ABSTRACT Brain cortical development results from the proliferation, differentiation, migration and maturation of many cell types.
Naomie Guille, Héloïse Monnet, Tristan Hourcade, Philippe Mailly, Martine Cohen‐Salmon, Anne‐Cécile Boulay   +5 more
wiley   +1 more source

A Rare Overlap of AQP4 and MOG Seropositivity in Neuromyelitis Optica Spectrum Disorder: A Case Report

Clinical and Experimental Neuroimmunology, Volume 17, Issue 3, August 2026.
ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is an immune‐mediated disorder of the central nervous system associated with autoantibodies against aquaporin‐4 (AQP4). This is distinct from myelin‐oligodendrocyte glycoprotein antibody‐associated disease (MOGAD), defined by anti‐MOG antibodies.
Sarah E. Butler, Siew Kar Chen, Mastura Monif   +2 more
wiley   +1 more source

The borderland of neuromyelitis optica

Practical Neurology, 2009
Neuromyelitis optica (NMO), also known as Devic’s disease, is an emerging clinical and pathological entity originally thought to be a variant of multiple sclerosis. Characterised by episodes of demyelination confined to the optic nerve and spinal cord, the discovery in such patients of antibodies to the aquaporin-4 channel has been largely responsible ...
Matthews, L, Baig, F, Palace, J, Turner, M   +3 more
openaire   +3 more sources

Predictors of Multiple Sclerosis After Clinically Isolated Syndrome: A Systematic Review and Meta‐Analysis

European Journal of Neurology, Volume 33, Issue 8, August 2026.
Most people with multiple sclerosis (MS) present with a clinically isolated syndrome (CIS); however, not all individuals with CIS are subsequently diagnosed with MS. We identified several clinical (younger age and monofocal presentation), imaging (number of T2 lesions, lesion location, gadolinium enhancement), and paraclinical (oligoclonal bands and ...
María Paula Zafra‐Sierra, Carolina Ferreira‐Atuesta, Daniela Sofía Rodríguez, Jairo Gaitán, Susana Otero, Mar Tintoré, Fred Lublin, Gavin Giovannoni, Jaime Toro, Saúl Reyes   +9 more
wiley   +1 more source

The Association of Neuromyelitis Optica without Myelitis and Systemic Lupus Erythematosus: A Case Report

Case Reports in Clinical Practice, 2018
Systemic lupus erythematosus is an autoimmune disease. Neuromyelitis optica (Devic’s disease) is an inflammatory disorder belonging to the central nervous system.
Asal Azami, Mohammadhassan Jokar
doaj  

Update on the Incidence of Paediatric Multiple Sclerosis, Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease, Aquaporin‐4 Antibody–Positive Neuromyelitis Optica Spectrum Disorder, and Other Acquired Demyelinating Syndromes in the Netherlands, 2017–2025, Including the COVID‐19 Pandemic

European Journal of Neurology, Volume 33, Issue 8, August 2026.
ABSTRACT Background Acquired demyelinating syndromes (ADS) in children include multiple sclerosis (MS), myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), aquaporin 4 antibody‐positive neuromyelitis optica spectrum disorder (AQP4+ NMOSD), and other seronegative disorders.
Sandy Molenaar, Michiel S. J. Buijze, Arlette L. Bruijstens, Yu Yi M. Wong, Maud A. Quist, C. Louk de Mol, Beatrijs H. A. Wokke, Rinze F. Neuteboom, Dutch Study Group for Paediatric Multiple Sclerosis and Acute Disseminated Encephalomyelitis   +8 more
wiley   +1 more source

New onset neuromyelitis optica in a young Nigerian woman with possible antiphospholipid syndrome: a case report

Journal of Medical Case Reports, 2008
Introduction Devic's neuromyelitis optica is an inflammatory demyelinating disease that targets the optic nerves and spinal cord. It has a worldwide distribution and distinctive features that distinguish it from multiple sclerosis.
Komolafe Morenikeji A, Komolafe Edward O, Sunmonu Taofiki A, Olateju SO, Asaleye CM, Adesina Olufemi A, Badmus SA   +6 more
doaj   +1 more source