Results 71 to 80 of about 16,378 (224)

Significance of molecular biomarkers in the diagnosis of neuromyelitis optica spectrum disorder [PDF]

Medicinski Podmladak
Discovery of antibodies to aquaporin-4 channels as a laboratory or molecular biomarker for neuromyelitis optica spectrum disorder contributed to a better understanding of the etiopathogenesis, with a clear separation of the clinical, neuroradiological ...
Andabaka Marko, Drulović Jelena, Novaković Ivana   +2 more
doaj   +1 more source

A case of neuromyelitis optica spectrum disorder with coexisting systemic lupus erythematosus

Journal of Community Hospital Internal Medicine Perspectives, 2021
Neuromyelitis Optica or Devic disease is changed to Neuromyelitis Optica spectrum disorder to include more diverse neurological and autoimmune manifestations. This is a severe relapsing autoimmune demyelinating disorder commonly affecting the optic nerve
Vikram Sangani, Mytri Pokal, Mamtha Balla, Ganesh Prasad Merugu, Sreedhar Adapa, Srikanth Naramala, Venu Madhav Konala   +6 more
doaj   +1 more source

Pharmacodynamic modelling and exposure–response assessment of inebilizumab in subjects with neuromyelitis optica spectrum disorders [PDF]

, 2022
Yan Li, Bing Wang, Dewei She, Ben Mitchell, Ryan Criste, Daniel Cimbora, Eliezer Katz, William A. Rees   +7 more
openalex   +1 more source

The Second Hit Hypothesis in Animal and Human Dystonia: The Role of Peripheral Nerve Trauma and Spinal Cord Injury

Movement Disorders, EarlyView.
The “second‐hit” hypothesis proposes that both a genetic predisposition and an environmental insult—such as peripheral nerve trauma or spinal cord injury—are required for dystonia development. This review explores how neuroinflammation and maladaptive plasticity, triggered by nerve and spinal cord injury, contribute to dystonia pathogenesis.
Lisa Harder‐Rauschenberger, Chi Wang Ip   +1 more
wiley   +1 more source

Myasthenia Gravis and Neuromyelitis Optica Association

Pediatric Neurology Briefs, 2012
Investigators at the University of Oxford, UK and 8 other international neurology centers describe the clinical, serological, and temporal associations of myasthenia gravis (MG) and neuromyelitis optica spectrum disorder (NMOSD) in 16 patients.
J Gordon Millichap
doaj   +1 more source

TREM2 Drives Neutrophil Extracellular Traps‐Induced Dendritic Cell Maturation and Contributes to Lupus Progression

Advanced Science, Volume 13, Issue 7, 3 February 2026.
TREM2 recognizes NETs‐derived MPO to promote DC maturation and antigen presentation, thereby exacerbating the autoimmune response in SLE. Mechanistically, TREM2 activation triggers the DAP12/SYK/ERK cascade and enhances NETs internalization by DCs, which in turn activates the cGAS/STING signaling pathway.
Jingxian Shu, Jiabi Liang, Linda Zeng, Shuping Zhong, Xueling Fang, Yating Xu, Yongjian Wu, Xi Huang   +7 more
wiley   +1 more source

Multidisciplinary rehabilitation for adults with neuromyelitis optica spectrum disorders: A pilot study

Journal of Rehabilitation Medicine, 2019
Objective: To provide detailed data on the effects of multidisciplinary rehabilitation for patients with neuromyelitis optica spectrum disorder with moderate to severe disability. Design: A pilot randomized control study.
Dong-Mei Suo, Lin-lin Liu, Kun Jia, Lin-jie Zhang, Li-Min Li, Jing Wang, Yuan Qi, Hai-jie Liu, Chun-Xiao Wan, Li Yang   +9 more
doaj   +1 more source

The history of neuromyelitis optica [PDF]

, 2013
The discovery of a novel serum autoantibody (termed NMO-IgG or AQP4-Ab) in a subset of patients in 2004 has revived interest in neuromyelitis optica (NMO).
Jarius, Sven, Wildemann, Brigitte
core   +1 more source

Microbial‐Immune Interplay in CNS Autoimmune Diseases: Lessons from Animal Models and Clinical Studies

European Journal of Immunology, Volume 56, Issue 2, February 2026.
Mechanism of action of the intestinal microbiota on CNS autoimmune diseases. Environmental factors shape gut microbiota composition; dysbiosis alters microbial metabolites and antigenic signals. These modulate innate and adaptive immunity, affect barrier integrity, and influence CNS‐resident cells such as microglia and astrocytes, contributing to ...
Matteo Ceccon, Francesca Ronchi
wiley   +1 more source

Hypersensitivity Responses in the Central Nervous System [PDF]

, 2015
Immune-mediated tissue damage or hypersensitivity can be mediated by autospecific IgG antibodies. Pathology results from activation of complement, and antibody-dependent cellular cytotoxicity (ADCC), mediated by inflammatory effector leukocytes include ...
Carsten Tue Berg, Marlene Thorsen Mørch, Nasrin eAsgari, Nasrin eAsgari, Reza eKhorooshi, Trevor eOwens   +5 more
core   +4 more sources