Results 51 to 60 of about 2,996,041 (224)

Inebilizumab in AQP4‐Seropositive NMOSD: One‐Year Follow‐Up From a Multicenter, Real‐World Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Real‐world evidence on inebilizumab among neuromyelitis optica spectrum disorder (NMOSD) patients is lacking. This study assessed inebilizumab among Chinese patients with aquaporin 4 autoantibody (AQP4‐IgG)‐seropositive NMOSD in a real‐world setting.
Mengcui Gui, Jiayang Zhan, Wei Li, Tao Jin, Dan He, Daishi Tian, Zhijun Li, Jing Lin, Yue Li, Hongyu Zhou, Bitao Bu   +10 more
wiley   +1 more source

Biotinidase deficiency in differential diagnosis of neuromyelitis optica spectrum disorder

, 2020
© 2020 Elsevier B.V.We present a case of biotinidase deficiency mimicking neuromyelitis optica spectrum disorder (NMOSD) with tetraparesis and transverse myelitis, who was diagnosed with profound biotinidase deficiency after developing optic atrophy and ...
YEVGİ, Recep, BİLGE, Nuray
core   +1 more source

Jaw clonus in neuromyelitis optica spectrum disorder with subsequent osmotic demyelination syndrome

Journal of Family Medicine and Primary Care, 2020
Jaw clonus, a fascinating, yet uncommon clinical sign, is suggestive of supranuclear lesions of the trigeminal nerve. It has previously been reported in association with amyotrophic lateral sclerosis.
Ritwik Ghosh, Devlina Roy, Souvik Dubey, Durjoy Lahiri, Subhankar Chatterjee, Josef Finsterer   +5 more
doaj   +1 more source

The Comprehensive Live Cell‐Based Cytotoxicity Assay for Monitoring Disease Activity and Guiding Rescue Therapy in Acute Attacks of NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuromyelitis optica spectrum disorder (NMOSD) is a devastating neurological disease that lacks serological biomarkers that can accurately reflect disease activity. We established a live cell‐based assay (LCBA) using serum with endogenous complement to quantify the overall cytotoxicity, offering a novel functional tool for monitoring
Xiaona Xu, Jie Ding, Yupeng Du, Guibao Luo, Jinming Li, Rui Liu, Xiaoyi Xu, Xiao Li, Minshu Li, Wei Jiang, Chunsheng Yang   +10 more
wiley   +1 more source

Neuromyelitis optica in patients with increased interferon alpha concentrations [PDF]

, 2020
International audienceRecombinant interferon alpha is used to treat several immunological, oncological, and infectious diseases,1 and various serious side-effects have been associated with its therapeutic use.
Hunt, David, Joanna, Wardlaw, Anu, Jacob, Nuno, Cordeiro, Vincent, Bondet, Irani, Sarosh, Nmosd Study Group, Scottish, Ondrej, Dolezal, Mcglasson, Sarah, Duffy, Darragh, Mathieu, Rodero, Crow, Yanick, Patrick, Statham, Williams, Jac, Katy, Murray, Robert, Wilson, Stewart, Wiseman, Alexa, Jury, Andrew P, Jackson, Shahd, Hamid, Christina, Hertel, Adrian, Hayday, Darragh Duffy, Vincent Bondet, David Hunt, Patrick Statham, Anu Jacob, Katy Murray, Nuno Cordeiro, Sarah McGlasson, Stewart Wiseman, Mathieu Rodero, Shahd Hamid, Christina Hertel, Robert Wilson, Andrew P Jackson, Ondrej Dolezal, Sarosh Irani, Adrian Hayday, Yanick Crow, Joanna Wardlaw, Alexa Jury, Jac Williams   +42 more
core   +1 more source

Neuromyelitis Optica Spectrum Disorder: A Case Report

Journal of Nepal Medical Association
Neuromyelitis optica spectrum disorder also known as Devic's disease is an autoimmune condition where the body produces antibodies against Aquaporin-4 in the astrocytes.
Prakriti Karki, Sagar Pahari, Nayan Neupane, Kushal Poudel, Nehal Asharaf   +4 more
doaj   +1 more source

Frequency and Phenotype of Coexisting Aquaporin‐4 and Autoimmune Encephalitis Autoantibodies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Among 9457 aquaporin‐4 (AQP4) immunoglobulin G‐positive patients, 2071 underwent autoimmune encephalitis antibody testing and 85 (4%) had coexisting antibodies, most commonly cerebrospinal fluid glial fibrillary acidic protein‐IgG and N‐methyl‐D‐aspartate receptor‐IgG, or serum high‐titer GAD65‐IgG.
Laura Cacciaguerra, Binxia Yang, Vanda A. Lennon, Shruti P. Agnihotri, Nusrat Ahsan, Karen S. Fernandez, Erin McLeod, Georgios Mangioris, William R. Meador, Wendy G. Mitchell, Jacqueline A. Nicholas, Amy M. L. Quek, Thomas Shoemaker, Kurt Sieloff, Matt C. Edmond, Rebekah A. Laggis, Kristin L. Flynn, Jessica A. Sagen, Emmanuelle Waubant, John J. Chen, Sarosh R. Irani, Andrew McKeon, Anastasia Zekeridou, Eoin P. Flanagan, Sean J. Pittock, Amy Kunchok   +25 more
wiley   +1 more source

Magnetic resonance imaging in neuromyelitis optica spectrum disorder

, 2021
Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory disease of the central nervous system (CNS) associated with antibodies to aquaporin‐4 (AQP4), which has distinct clinical, radiological and pathological features, but also has some overlap
Arnett, Simon, Bhuta, Sandeep, Clarke, Laura, Lilley, Kate, Liao, Jacky, Broadley, Simon A, Kate Lilley, Simon Arnett, Sandeep Bhuta, Jacky Liao, Laura Clarke, Simon A Broadley   +11 more
core   +1 more source

Investigation of Complement Activation and Cytokine Signatures in AQP4+ NMOSD, MOGAD, and MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Aquaporin‐4‐IgG seropositive neuromyelitis optica spectrum disorder (AQP4+ NMOSD), myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD), and multiple sclerosis (MS) are pathophysiologically distinct neuroinflammatory disorders. Complement activation is a major mechanism of injury in AQP4+ NMOSD, whereas its role in
Angeliki G. Filippatou, Susana Dominguez‐Penuela, David Acero‐Garces, Georgios Gakis, Matthew D. Smith, Yasmin Resto, Maria Reyes‐Mantilla, Haiwen Chen, Isabella Hernandez, Yana Said, Andrea Salazar‐Camelo, Christina Huynh, Alessia Tassoni, Ted Yednock, Rick Artis, Yaisa Andrews‐Zwilling, Scott D. Newsome, Shiv Saidha, Pavan Bhargava, Ellen M. Mowry, Kathryn C. Fitzgerald, Peter A. Calabresi, Carlos A. Pardo, Elias S. Sotirchos   +23 more
wiley   +1 more source

Differentiation between multiple sclerosis and neuromyelitis optica spectrum disorder using a deep learning model

Scientific Reports, 2023
Multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) are autoimmune inflammatory disorders of the central nervous system (CNS) with similar characteristics.
Jin Myoung Seok, Wanzee Cho, Yeon Hak Chung, Hyunjin Ju, Sung Tae Kim, Joon-Kyung Seong, Ju-Hong Min   +6 more
doaj   +1 more source