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Neuromyelitis Optica Spectrum Disorders
Brain and nerve = Shinkei kenkyu no shinpo, 2023Neuromyelitis optica spectrum disorders (NMOSD) are inflammatory autoimmune disorders of the central nervous system, that primarily cause optic neuritis and myelitis. Aquaporin-4 (AQP4) antibody is the key in NMOSD pathophysiology, which causes astrocytopathy, demyelination, and neuropathy through complement activation and cell-mediated immunity ...
Xiaoyang Li, Andrew McKeon
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Pediatric Neuromyelitis Optica Spectrum Disorder
Seminars in Pediatric Neurology, 2023Neuromyelitis Optica Spectrum Disorder (NMOSD) is a demyelinating disease with a high relapse rate and risk of disability accrual. The condition is an astrocytopathy, with antibodies to the aquaporin-4 (AQP4) water channel being detected in AQP4-IgG seropositive disease. Presentation is uncommon in the pediatric age range, accounting for about 3%-5% of
Kelsey, Poisson +2 more
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Neuromyelitis optica and neuromyelitis optica spectrum disorders
Current Opinion in Neurology, 2017Purpose of review The discovery of highly specific auto-antibodies directed against the water channel aquaporin 4 was a quantum leap in the definition, classification and management of neuromyelitis optica (NMO). Herein, we propose an update on epidemiological, clinical and therapeutic advances in the field, underlining unmet ...
Romain, Marignier +2 more
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Neuromyelitis optica and neuromyelitis optica spectrum disorders
Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 2019The review is devoted to up-to-date data on epidemiology, aspects of the pathogenesis of neuromyelitis optica (NMO) and neuromyelitis optica spectrum disorders (NMOSD). The authors consider a role of myelin oligodendrocyte glycoprotein immunoglobulin G (MOG-IgG) in the syndromes phenotypically similar to NMO and NMOSD. Special attention is drawn to the
T.O. Simaniv +3 more
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Neuromyelitis Optica Spectrum Disorders
Continuum, 2022This article reviews the cardinal clinical features, distinct immunopathology, current diagnostic criteria, relapse-related risk factors, emerging biomarkers, and evolving treatment strategies pertaining to neuromyelitis optica spectrum disorders (NMOSD).The discovery of the pathogenic aquaporin-4 (AQP4)-IgG autoantibody and characterization of NMOSD ...
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Neuromyelitis Optica Spectrum Disorders
Current Neurology and Neuroscience Reports, 2014Since the discovery of aquaporin 4-IgG, a sensitive and highly specific biomarker of neuromyelitis optica (NMO), a wide range of syndromes have been recognized as being associated with this condition. This observation has led to new proposed terminology for the entire disorder, NMO spectrum disorders (NMOSD).
Eoin P, Flanagan, Brian G, Weinshenker
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Neuromyelitis Optica Spectrum Disorders
Neuroimaging Clinics of North America, 2017Neuromyelitis optica (NMO) is clinically characterized by severe optic neuritis and transverse myelitis, but recent studies with anti-aquaporin-4-antibody specific to NMO have revealed that the clinical spectrum is wider than previously thought. International consensus diagnostic criteria propose NMO spectrum disorders (NMOSD) as the term to define the
Tetsuya, Akaishi +4 more
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Epidemiology of neuromyelitis optica spectrum disorder
Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 2021Neuromyelitis optica spectrum disorder (NMOSD) is a group of rare and mostly severe autoimmune demyelinating central nervous system disorders which prevalence is 0.7-1 per 100.000 population and incidence is 0.037-0.73 per 100.000 person-years. NMOSD may present as a combination of uni- or bilateral optic neuritis, transverse myelitis or lesions of ...
M A, Sherman, A N, Boyko
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Neuromyelitis Optica Spectrum Disorder and Uveitis
Ocular Immunology and Inflammation, 2021Neuromyelitis Optica Spectrum Disorder (NMOSD) is a rare disease marked by CNS demyelination with a predilection for the optic nerve and spinal cord often resulting in severe vision loss. We aimed to characterize uveitis occurring in the setting of NMOSD.Retrospective chart review.Of 572 NMOSD patients, 1% were found to have uveitis with a relative ...
Andrew R, Carey, J Fernando, Arevalo
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Neuromyelitis Optica Spectrum Disorders
Continuum, 2016This article provides a practical approach for providers caring for patients with neuromyelitis optica (NMO) spectrum disorders. Clinical and imaging features, diagnostic criteria, treatment of acute exacerbations, chronic preventive therapy, and symptom management in NMO spectrum disorders are discussed.The rapid pace of research in NMO spectrum ...
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