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Pediatric Neuromyelitis Optica Spectrum Disorders
Current Treatment Options in Neurology, 2018Neuromyelitis optica spectrum disorders (NMOSDs) are a group of inflammatory and demyelinating disorders of the central nervous system that can occur in children and adults. The classic presentation of NMOSD is characterized by optic neuritis and transverse myelitis, but other presentations are also recognized, expanding the disease as NMO spectrum ...
Grace Y, Gombolay, Tanuja, Chitnis
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Neuromyelitis Optica Spectrum Disorders
Continuum, 2010Neuromyelitis optica is an uncommon inflammatory demyelinating CNS disorder that is distinct from multiple sclerosis with respect to clinical, laboratory, neuroimaging, and prognostic characteristics. Autoantibodies that target aquaporin-4 are highly specific for neuromyelitis optica and have helped define a spectrum of disease beyond the classic ...
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Immunobiology of neuromyelitis optica spectrum disorders
Current Opinion in Neurobiology, 2022Neuromyelitis optica spectrum disorder (NMOSD) is a rare autoimmune inflammatory disease of the central nervous system. Most of the cases are positive for autoantibodies targeting the water channel aquaporin-4 (AQP4-IgG). Activated B and T cells, innate immunity cells, pro-inflammatory cytokines, and activated complement contribute to the formation of ...
Daissy Liliana Mora Cuervo +2 more
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Neuromyelitis Optica Spectrum Disorders
2020Neuromyelitis optica spectrum disorders (NMOSD) are a heterogeneous group of inflammatory, demyelinating and antibody-mediated diseases of the central nervous system (CNS). The anti-aquaporin-4-IgG (AQP4-IgG) seems to be the pathogenetic agent, being present in the large majority of patients, although seronegative forms can occur.
Massimo Filippi, Maria A. Rocca
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Neuromyelitis optica spectrum disorder and menstruation
Revue Neurologique, 2018Gender issues and the female preponderance in neuromyelitis optica spectrum disorder (NMOSD) have been investigated before, yet the interplay between NMOSD and menstrual characteristics has remained unknown. Thus, the aim was to compare menstrual cycle patterns and their symptoms in NMOSD patients and healthy women.This cross-sectional study was ...
Shervin, Badihian +4 more
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Neuromyelitis optica spectrum disorder: pathophysiological approach
International Journal of Neuroscience, 2022Aim: To review the main pathological findings of Neuromyelitis Optica Spectrum Disorder (NMOSD) associated with the presence of autoantibodies to aquaporin-4 (AQP4) as well as the mechanisms of astrocyte dysfunction and demyelination. Methods: An comprehensive search of the literature in the field was carried out using the database of The National ...
Mario A. Mireles-Ramírez +7 more
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Neuromyelitis Optica Spectrum Disorder
2019Neuromyelitis optica (NMO) is an autoimmune disease of the central nervous system, also known as Devic’s syndrome, that typically manifests with optic neuritis and transverse myelitis and, like other antibody-mediated autoimmune diseases, primarily affects women.
Samira Saadoun +2 more
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Infections in neuromyelitis optica spectrum disorder
Journal of Clinical Neuroscience, 2018Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory astrocytopathy that has both genetic and environmental causes. A growing body of evidence suggests that the presence of several infectious agents correlates with the development of NMOSD.
Zhong, X. +7 more
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Treatment of neuromyelitis optica spectrum disorders
Current Opinion in Rheumatology, 2019Purpose of review This review discusses concepts for diagnosing neuromyelitis optica spectrum disorders (NMOSD), distinguishing NMOSD from other inflammatory diseases of the central nervous system, and highlights recent and forthcoming data on acute and maintenance therapy of NMOSD.
Andrew R, Romeo, Benjamin M, Segal
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Imaging of Neuromyelitis Optica Spectrum Disorders
Seminars in Ultrasound, CT and MRI, 2020Neuromyelitis optica (NMO) is a rare and chronic disabling autoimmune astrocytopathy of the central nervous system. Current advances regarding aquaporin-4 antibody function facilitate the understanding of clinical manifestations and imaging findings beyond optic neuritis and transverse myelitis.
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