Results 1 to 10 of about 1,818,525 (389)
Single-neuron perturbations reveal feature-specific competition in V1
Nature, 2019 The computations performed by local neural populations, such as a cortical layer, are typically inferred from anatomical connectivity and observations of neural activity.
Selmaan N Chettih, Christopher D Harvey
exaly +2 more sources
Sumoylation regulates the assembly and activity of the SMN complex
Nature Communications, 2021 Sumoylation is important for the assembly and function of the SMN complex, which plays a central role in RNA processing. Here the authors show that loss of this posttranslational modification impairs the ability of SMN to correct selective deficits in ...
Giulietta M. Riboldi +12 more
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Molecular Brain, 2021 Introduction N-Methyl-D-aspartate receptors (NMDARs) play a critical role in different forms of plasticity in the central nervous system. NMDARs are always assembled in tetrameric form, in which two GluN1 subunits and two GluN2 and/or GluN3 subunits ...
Qi-Yu Chen +8 more
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Redox dysregulation as a driver for DNA damage and its relationship to neurodegenerative diseases
Translational Neurodegeneration, 2023 Redox homeostasis refers to the balance between the production of reactive oxygen species (ROS) as well as reactive nitrogen species (RNS), and their elimination by antioxidants. It is linked to all important cellular activities and oxidative stress is a
Sina Shadfar +3 more
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Human neocortical expansion involves glutamatergic neuron diversification
Nature, 2021 The neocortex is disproportionately expanded in human compared with mouse1,2, both in its total volume relative to subcortical structures and in the proportion occupied by supragranular layers composed of neurons that selectively make connections within ...
J. Berg +146 more
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Scientific Reports, 2023 Amyotrophic lateral sclerosis (ALS) is a severely debilitating neurodegenerative condition that is part of the same disease spectrum as frontotemporal dementia (FTD).
Audrey M. G. Ragagnin +22 more
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NISP: Pruning Networks Using Neuron Importance Score Propagation [PDF]
2018 IEEE/CVF Conference on Computer Vision and Pattern Recognition, 2017 To reduce the significant redundancy in deep Convolutional Neural Networks (CNNs), most existing methods prune neurons by only considering the statistics of an individual layer or two consecutive layers (e.g., prune one layer to minimize the ...
Ruichi Yu +8 more
semanticscholar +1 more source
Molecular Brain, 2021 Machado-Joseph disease (MJD, also known as spinocerebellar ataxia type 3) is a fatal neurodegenerative disease that impairs control and coordination of movement.
Maxinne Watchon +12 more
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Intrinsic functional neuron-type selectivity of transcranial focused ultrasound neuromodulation
Nature Communications, 2021 Transcranial focused ultrasound (tFUS) is a promising neuromodulation technique, but its mechanisms remain unclear. We hypothesize that if tFUS parameters exhibit distinct modulation effects in different neuron populations, then the mechanism can be ...
Kai Yu +3 more
semanticscholar +1 more source
Opinion: more mouse models and more translation needed for ALS
Molecular Neurodegeneration, 2023 Amyotrophic lateral sclerosis is a complex disorder most of which is ‘sporadic’ of unknown origin but approximately 10% is familial, arising from single mutations in any of more than 30 genes.
Elizabeth M.C. Fisher +9 more
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