Results 1 to 10 of about 1,368,537 (360)

Correction to: Ascending noradrenergic excitation from the locus coeruleus to the anterior cingulate cortex

open access: yesMolecular Brain, 2020
An amendment to this paper has been published and can be accessed via the original article.
Kohei Koga   +10 more
doaj   +1 more source

Pharmacological inhibition of HDAC6 improves muscle phenotypes in dystrophin-deficient mice by downregulating TGF-β via Smad3 acetylation

open access: yesNature Communications, 2022
Here, authors show that Smad3 acetylation via HDAC6 inhibition reverses Duchenne muscular dystrophy-like symptoms in the mdx mouse model, suggesting a potential therapeutic target for the disorder.
Alexis Osseni   +10 more
doaj   +1 more source

Microvascular decompression for hemifacial spasm: a review of twenty-one operated cases

open access: yesThe Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 2020
Background Microvascular decompression of facial nerve provides definitive and long-term cure for hemifacial spasm. We review our experience of treating hemifacial spasm by microvascular decompression.
Amey P. Patankar
doaj   +1 more source

C9orf72-ALS human iPSC microglia are pro-inflammatory and toxic to co-cultured motor neurons via MMP9

open access: yesNature Communications, 2023
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive motor neuron loss, with additional pathophysiological involvement of non-neuronal cells such as microglia.
Björn F. Vahsen   +18 more
doaj   +1 more source

An artificial sensory neuron with visual-haptic fusion

open access: yesNature Communications, 2020
Human behaviors are extremely sophisticated, relying on the adaptive, plastic and event-driven network of sensory neurons. Such neuronal system analyzes multiple sensory cues efficiently to establish accurate depiction of the environment.
Changjin Wan   +9 more
semanticscholar   +1 more source

A Stem Cell Model of the Motor Circuit Uncouples Motor Neuron Death from Hyperexcitability Induced by SMN Deficiency

open access: yesCell Reports, 2016
In spinal muscular atrophy, a neurodegenerative disease caused by ubiquitous deficiency in the survival motor neuron (SMN) protein, sensory-motor synaptic dysfunction and increased excitability precede motor neuron (MN) loss.
Christian M. Simon   +5 more
doaj   +1 more source

Foetal neural progenitors contribute to postnatal circuits formation ex vivo: an electrophysiological investigation

open access: yesMolecular Brain, 2020
Neuronal progenitor cells (NPC) play an essential role in homeostasis of the central nervous system (CNS). Considering their ability to differentiate into specific lineages, their manipulation and control could have a major therapeutic impact for those ...
Matteo Manzati   +3 more
doaj   +1 more source

Synaptic potentiation of anterior cingulate cortex contributes to chronic pain of Parkinson’s disease

open access: yesMolecular Brain, 2021
Parkinson’s disease (PD) is a multi-system neurodegenerative disorder. Patients with PD often suffer chronic pain. In the present study, we investigated motor, sensory and emotional changes in three different PD mice models.
Zhaoxiang Zhou   +13 more
doaj   +1 more source

Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration

open access: yesNature Communications, 2019
Microglia maintain brain homeostasis by removing neuron-derived components such as myelin and cell debris. The evidence linking microglia to neurodegenerative diseases is growing; however, the precise mechanisms remain poorly understood.
Insup Choi   +7 more
semanticscholar   +1 more source

Nucleolar reorganization after cellular stress is orchestrated by SMN shuttling between nuclear compartments

open access: yesNature Communications, 2023
Spinal muscular atrophy is an autosomal recessive neuromuscular disease caused by mutations in the multifunctional protein Survival of Motor Neuron, or SMN.
Shaqraa Musawi   +15 more
doaj   +1 more source

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