Results 1 to 10 of about 257,577 (143)
Sumoylation regulates the assembly and activity of the SMN complex
Nature Communications, 2021 Sumoylation is important for the assembly and function of the SMN complex, which plays a central role in RNA processing. Here the authors show that loss of this posttranslational modification impairs the ability of SMN to correct selective deficits in ...
Giulietta M. Riboldi +12 more
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Molecular Brain, 2021 Introduction N-Methyl-D-aspartate receptors (NMDARs) play a critical role in different forms of plasticity in the central nervous system. NMDARs are always assembled in tetrameric form, in which two GluN1 subunits and two GluN2 and/or GluN3 subunits ...
Qi-Yu Chen +8 more
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Redox dysregulation as a driver for DNA damage and its relationship to neurodegenerative diseases
Translational Neurodegeneration, 2023 Redox homeostasis refers to the balance between the production of reactive oxygen species (ROS) as well as reactive nitrogen species (RNS), and their elimination by antioxidants. It is linked to all important cellular activities and oxidative stress is a
Sina Shadfar +3 more
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Scientific Reports, 2023 Amyotrophic lateral sclerosis (ALS) is a severely debilitating neurodegenerative condition that is part of the same disease spectrum as frontotemporal dementia (FTD).
Audrey M. G. Ragagnin +22 more
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Molecular Brain, 2021 Machado-Joseph disease (MJD, also known as spinocerebellar ataxia type 3) is a fatal neurodegenerative disease that impairs control and coordination of movement.
Maxinne Watchon +12 more
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Opinion: more mouse models and more translation needed for ALS
Molecular Neurodegeneration, 2023 Amyotrophic lateral sclerosis is a complex disorder most of which is ‘sporadic’ of unknown origin but approximately 10% is familial, arising from single mutations in any of more than 30 genes.
Elizabeth M.C. Fisher +9 more
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Sex difference in synaptic plasticity in the anterior cingulate cortex of adult mice
Molecular Brain, 2020 Sex differences in certain types of pain sensitivity and emotional responses have been previously reported. Synaptic plasticity is a key cellular mechanism for pain perception and emotional regulation, including long-term potentiation (LTP) and long-term
Ren-Hao Liu +3 more
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Contagious itch can be induced in humans but not in rodents
Molecular Brain, 2019 Itch contagion has been reported in human when people watch someone scratching in a video. The basic mechanism of contagious itch induced by scratching video is still being investigated.
Jing-Shan Lu +7 more
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Ascending noradrenergic excitation from the locus coeruleus to the anterior cingulate cortex
Molecular Brain, 2020 Anterior cingulate cortex (ACC) plays important roles in sensory perception including pain and itch. Neurons in the ACC receive various neuromodulatory inputs from subcortical structures, including locus coeruleus noradrenaline (LC-NA) neurons.
Kohei Koga +10 more
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Molecular Brain, 2023 Long-term potentiation (LTP) is a key cellular mechanism for learning and memory, and recent studies in the hippocampus found that LTP was impaired in aged animals. Previous studies of cortical LTP have focused primarily on the homosynaptic plasticity in
Si-Bo Zhou +9 more
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