Results 261 to 270 of about 9,342,488 (306)

SCG 10, A neuron-specific growth-associated protein in Alzheimer's disease

Neurobiology of Aging, 1995
Neuronal growth-associated proteins (nGAPs) are markers of neuronal process outgrowth and are associated with both degenerative and sprouting responses in Alzheimer's disease (AD) brain. To study possible involvement of SCG10, an nGAP, in AD, we cloned human SCG10 cDNA and analyzed SCG-10 at mRNA and protein levels in control and AD brains. The deduced
T, Okazaki, H, Wang, E, Masliah, M, Cao, S A, Johnson, M, Sundsmo, T, Saitoh, N, Mori   +7 more
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Determination and characterization of neuron specific protein (NSP) associated enolase activity

Biochemical and Biophysical Research Communications, 1976
Abstract Fractionation of the 40–80% (NH 4 ) 2 SO 4 fraction of a soluble rat brain extract on DEAE cellulose resolves three species of enolase activity, two of which react with antiserum to neuron specific protein from rat (NSP-R) and one which does not react. Direct assay of pure neuron specific protein from rat, cat and human brain (NSP-R, NSP-C,
P J, Marangos, C, Zomzely-Neurath, C, York   +2 more
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The Neuron-Specific Protein PGP 9.5 Is a Ubiquitin Carboxyl-Terminal Hydrolase

Science, 1989
A complementary DNA (cDNA) for ubiquitin carboxyl-terminal hydrolase isozyme L3 was cloned from human B cells. The cDNA encodes a protein of 230 amino acids with a molecular mass of 26.182 daltons. The human protein is very similar to the bovine homolog, with only three amino acids differing in over 100 residues compared.
K D, Wilkinson, K M, Lee, S, Deshpande, P, Duerksen-Hughes, J M, Boss, J, Pohl   +5 more
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Neurone specific enolase and S100 protein as possible prognostic indicators in melanoma*

Histopathology, 1984
Fourteen cases of primary melanoma and 25 of their subsequent metastases were stained for Neurone Specific Enolase (NSE) and S100 protein. Intensity of staining for NSE and S100 protein broadly corresponded in 11 of the primary lesions and was disparate in three.
J, Rode, A P, Dhillon
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Stac, a Novel Neuron-Specific Protein with Cysteine-Rich and SH3 Domains

Biochemical and Biophysical Research Communications, 1996
In RLGS-M (restriction landmark genomic scanning using methylation-sensitive endonuclease) displays of mouse brains, spot #91 is one of tissue-specific gel spots whose intensity changes developmentally. We have now cloned the corresponding cDNA from this spot and analyzed its structure and expression.
H, Suzuki, J, Kawai, C, Taga, T, Yaoi, A, Hara, K, Hirose, Y, Hayashizaki, S, Watanabe   +7 more
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Structure and regulation of the gene encoding the neuron-specific protein PEP-19

Molecular Brain Research, 1993
PEP-19 is a 61 amino acid polypeptide that is localized to neurons. PEP-19 is translated from a 0.6 kb poly(A)+ RNA; however, the gene from which it is transcribed spans more than 30 kbp and comprises three exons and two large introns. Exon 1 contains the 5'-untranslated region of PEP-19 and the first three amino acids of the coding sequence; exon 2 ...
L, Sangameswaran, J I, Morgan
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A rapid purification of synapsin I: A neuron specific spectrin binding protein

Brain Research Bulletin, 1986
We have developed a one chromatographic step isolation protocol for the neuron specific protein synapsin I. This procedure results in a yield of 80 micrograms/g brain, which is ten fold better than the highest yield yet reported for this protein. The authenticity of the synapsin I isolated by this procedure is demonstrated by comigration with authentic
K E, Krebs, I S, Zagon, S R, Goodman
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Distribution of neurofilament protein and neuron-specific enolase in peripheral neuronal tumours

Virchows Archiv A Pathological Anatomy and Histopathology, 1985
Peripheral neuronal tumours were studied by the peroxidase-antiperoxidase (PAP) method for the presence of the neurofilament protein (NFP) and neuron-specific enolase (NSE). All cases of ganglioneuromas and ganglioneuroblastomas were positive for NFP and NSE. Both markers were observed only in tumour cells showing differentiation towards ganglion cells.
A, Sasaki, A, Ogawa, Y, Nakazato, Y, Ishida   +3 more
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The intracellular domain of amyloid precursor protein induces neuron-specific apoptosis

Neuroscience Letters, 2008
Although amyloid precursor protein (APP) has central roles in Alzheimer's disease, the physiological functions of this protein have yet to be fully elucidated. APP homologues show significant sequence conservation in the intracellular domain through evolution, which may reflect the functional importance of the intracellular domain of APP (AICD).
Kohzo, Nakayama, Takeshi, Ohkawara, Masahiro, Hiratochi, Chang-Sung, Koh, Hisashi, Nagase   +4 more
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Protein Kinase C  (PKC ): Function of Neuron Specific Isotype

Journal of Biochemistry, 2002
The gamma isotype of protein kinase C (PKC gamma) is a member of the classical PKC (cPKC) subfamily which is activated by Ca(2+) and diacylglycerol in the presence of phosphatidylserine. Physiologically, PKC gamma is activated by a mechanism coupled with receptor-mediated breakdown of inositol phospholipid as other cPKC isotypes such as PKC alpha and ...
N. Saito, Y. Shirai
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