Results 61 to 70 of about 9,342,488 (306)
FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
Uncovering Discrete Synaptic Proteomes to Understand Neurological Disorders
Proteomes, 2018 The mammalian nervous system is an immensely heterogeneous organ composed of a diverse collection of neuronal types that interconnect in complex patterns.
Yi-Zhi Wang, Jeffrey N. Savas
doaj +1 more source
Postingestive Modulation of Food Seeking Depends on Vagus-Mediated Dopamine Neuron Activity [PDF]
, 2020 Postingestive nutrient sensing can induce food preferences. However, much less is known about the ability of postingestive signals to modulate food-seeking behaviors.
Gerfen, Charles R. +6 more
core +1 more source
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
Фармакоэкономика, 2015 becoming increasingly widespread evaluation of the blood-brain barrier (BBB) resistance to predict severity and outcome of epilepsy, stroke, traumatic brain injury (TBI) and other neurological disorders by assessment of neuron-specific proteins (NSP ...
D. V. Blinov
doaj
Cell ReportsSummary: Cell-type-specific alternative splicing (AS) enables differential gene isoform expression between diverse neuron types with distinct identities and functions.
Daniel F. Moakley +6 more
doaj +1 more source
Mutant VAPB: Culprit or Innocent Bystander of Amyotrophic Lateral Sclerosis?
Contact, 2021 Nearly twenty years ago a mutation in the VAPB gene, resulting in a proline to serine substitution (p.P56S), was identified as the cause of a rare, slowly progressing, familial form of the motor neuron degenerative disease Amyotrophic Lateral Sclerosis ...
Nica Borgese +3 more
doaj +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Акушерство, гинекология и репродукция, 2016 There is a non-diminishing interest in the assessment of the blood-brain barrier (BBB) resistance and prediction of the severity and outcomes of the perinatal hypoxic-ischemic lesion of the CNS using the analysis of concentration of neuron-specific ...
D. V. Blinov
doaj
Conversion of Fibroblasts to Neural Cells by p53 Depletion
Cell Reports, 2014 Conversion from fibroblasts to neurons has recently been successfully induced. However, the underlying mechanisms are poorly understood. Here, we find that depletion of p53 alone converts fibroblasts into all three major neural lineages.
Di Zhou +11 more
doaj +1 more source