Results 71 to 80 of about 9,342,488 (306)

The protein interactome of the Neuron Specific Gene family (NSG1-3)

ABSTRACT The Neuron-Specific Gene (NSG) family members (NSG1-3) play critical and diverse roles in neuronal protein trafficking, but their precise molecular functions remain poorly understood. Here, we employed proximity-labeling proteomics to map the interactomes of each NSG protein.
Antonio Serrano Rodriguez, Malene Overby, Upasna Srivastava, Praveen Chander, Liliana Vega, Sandy Wilson, Katherine E. Zychowski, Srikant Rangaraju, Heidi Kaastrup-Müeller, Jason P. Weick   +9 more
openaire   +2 more sources

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Effects of sensorimotor learning on the human mirror neuron system [PDF]

, 2009
The discovery, in the monkey, of “mirror” neurons, which fire in response both to the performance and to the observation of specific actions, has prompted extensive research into their properties, and into the possible functions of a putative mirror ...
Catmur, C, Catmur, C.
core  

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Neuron-Subtype-Specific Expression, Interaction Affinities, and Specificity Determinants of DIP/Dpr Cell Recognition Proteins [PDF]

, 2018
Binding between DIP and Dpr neuronal recognition proteins has been proposed to regulate synaptic connections between lamina and medulla neurons in the Drosophila visual system. Each lamina neuron was previously shown to express many Dprs.
Sergeeva, Alina P, Patel, Saurabh D, Zipursky, S Lawrence, Xu, Shuwa, Xiao, Qi, Cosmanescu, Filip, Tan, Liming, Katsamba, Phinikoula S, Nern, Aljoscha, Honig, Barry, Ahlsen, Goran, Bellen, Hugo J, Shapiro, Lawrence, Nagarkar-Jaiswal, Sonal, Brewer, Joshua J   +14 more
core   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

Mitochondrial translation and coordinated cytosolic translation in metabolic homeostasis and disease

FEBS Letters, EarlyView.
Mitochondrial function depends on coordinated protein production from the nuclear and mitochondrial genomes. This review highlights how cytosolic and mitochondrial translation, mRNA localization, protein import, and respiratory complex assembly are integrated to maintain mitochondrial proteostasis and function.
Boseon Kim, Thi Thanh Mai Tran, Nakyung Kang, Min‐Woo Lee, Mihye Lee   +4 more
wiley   +1 more source

Table_1_Toward Development of Neuron Specific Transduction After Systemic Delivery of Viral Vectors.DOCX

, 2021
Widespread transduction of the CNS with a single, non-invasive systemic injection of adeno-associated virus is now possible due to the creation of blood-brain barrier-permeable capsids.
Kevin R. Nash (9246094), Ikenna P. Njoku (11333859), Marcia N. Gordon (9983294), Meghana R. Ranabothu (11333865), Dylan J. Finneran (5613065), Diego Flores-Pazarin (11333862), David Morgan (479503)   +6 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Down-Regulation of Essential Synaptic Components by GI-Tract Microbiome-Derived Lipopolysaccharide (LPS) in LPS-Treated Human Neuronal-Glial (HNG) Cells in Primary Culture: Relevance to Alzheimer’s Disease (AD)

Frontiers in Cellular Neuroscience, 2019
Trans-synaptic neurotransmission of both electrical and neurochemical information in the central nervous system (CNS) is achieved through a highly interactive network of neuron-specific synaptic proteins that include pre-synaptic and post-synaptic ...
Yuhai Zhao, Yuhai Zhao, Nathan M. Sharfman, Vivian R. Jaber, Walter J. Lukiw, Walter J. Lukiw, Walter J. Lukiw   +6 more
doaj   +1 more source