Results 51 to 60 of about 9,342,488 (306)

The state of the endothelium and the level of neuron-specific markers of nerve tissue damage in rats with chronic malathion intoxication and methods of correction

Сибирский научный медицинский журнал
The state of the vascular endothelium, the severity of neurodegenerative processes, their relationship, as well as possible correction methods for chronic malathion intoxication have not been practically studied.
D. V. Srubilin, M. A. Isakova, A. D. Srubilin, D. A. Enikeev, M. K. Ignatova   +4 more
doaj   +1 more source

Specific nuclear envelope transmembrane proteins can promote the location of chromosomes to and from the nuclear periphery [PDF]

, 2013
BACKGROUND: Different cell types have distinctive patterns of chromosome positioning in the nucleus. Although ectopic affinity-tethering of specific loci can be used to relocate chromosomes to the nuclear periphery, endogenous nuclear envelope proteins ...
Vassiliki Lazou, Harrison, David J, Schirmer, Eric C, David J Harrison, Zuleger, Nikolaj, de Las Heras, Jose I, Wendy A Bickmore, Dzmitry G Batrakou, Lazou, Vassiliki, Batrakou, Dzmitry G, Jose I de las Heras, Bickmore, Wendy A, Nikolaj Zuleger, Shelagh Boyle, Kelly, David A, Korfali, Nadia, Nadia Korfali, Glenn E Morris, Eric C Schirmer, Boyle, Shelagh, David A Kelly, K Natalie Randles, Randles, K Natalie, Morris, Glenn E, Harrison, David J; id_orcid   +24 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Conditional Synaptic Vesicle Markers for Drosophila

G3: Genes, Genomes, Genetics, 2019
The release of neurotransmitters from synaptic vesicles (SVs) at pre-synaptic release sites is the principle means by which information transfer between neurons occurs.
Jessica L. Williams, Harold K. Shearin, R. Steven Stowers   +2 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Leucine-rich repeat-containing synaptic adhesion molecules as organizers of synaptic specificity and diversity

Experimental and Molecular Medicine, 2018
Brain circuits: Regulating synaptic connections Further analysis of synaptic proteins will provide insights into the functioning of neural circuits and associated brain disorders.
Anna Schroeder, Joris de Wit
doaj   +1 more source

Transcriptional and Post-Transcriptional Mechanisms of the Development of Neocortical Lamination

Frontiers in Neuroanatomy, 2017
The neocortex is a laminated brain structure that is the seat of higher cognitive capacity and responses, long-term memory, sensory and emotional functions, and voluntary motor behavior.
Tatiana Popovitchenko, Mladen-Roko Rasin
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Functional Access to Neuron Subclasses in Rodent and Primate Forebrain

Cell Reports, 2019
Summary: Viral vectors enable foreign proteins to be expressed in brains of non-genetic species, including non-human primates. However, viruses targeting specific neuron classes have proved elusive.
Preeti Mehta, Lauren Kreeger, Dennis C. Wylie, Jagruti J. Pattadkal, Tara Lusignan, Matthew J. Davis, Gergely F. Turi, Wen-Ke Li, Matthew P. Whitmire, Yuzhi Chen, Bridget L. Kajs, Eyal Seidemann, Nicholas J. Priebe, Attila Losonczy, Boris V. Zemelman   +14 more
doaj   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source