Results 31 to 40 of about 9,342,488 (306)

Axon-Targeting Motifs: Mechanisms and Applications of Enhancing Axonal Localisation of Transmembrane Proteins

Cells, 2022
Neuronal polarity established in developing neurons ensures proper function in the mature nervous system. As functionally distinct cellular compartments, axons and dendrites often require different subsets of proteins to maintain synaptic transmission ...
Lloyd J. Steele-Nicholson, Melissa R. Andrews   +1 more
doaj   +1 more source

Melanoma-associated adhesion molecule MUC18/MCAM (CD146) and transcriptional regulator Mader in normal human CNS [PDF]

, 1998
The proteins MUC18 and Mader have been identified as markers of tumor progression in melanoma cells, MUC18, also known as MCAM (melanoma cell adhesion molecule) and as CD146 (endothelial antigen), is a cell adhesion molecule belonging to the ...
Müller, Norbert, Johnson, Judith P., Kirsch, Kathrin H., Hampel, Harald, Schwarz, Markus J., Ackenheil, Manfred, Penning, Randolph, Körschenhausen, Dirk   +7 more
core   +1 more source

Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal [PDF]

The Journal of Neuroscience, 1988
We used an antiserum against purified cholinergic synaptic vesicles from Torpedo and expression screening to isolate a cDNA clone encoding synuclein, a 143 amino acid neuron-specific protein. A cDNA clone was also isolated from a rat brain cDNA library that encodes a highly homologous 140 amino acid protein.
L, Maroteaux, J T, Campanelli, R H, Scheller   +2 more
openaire   +2 more sources

Expression of the neuron-specific protein CHD5 is an independent marker of outcome in neuroblastoma [PDF]

Molecular Cancer, 2010
Abstract Background The chromodomain, helicase DNA-binding protein 5 (CHD5) is a potential tumor suppressor gene located on chromosome 1p36, a region recurrently deleted in high risk neuroblastoma (NB). Previous data have shown that CHD5
Galván Patricia, Perez-Atayde Antonio R, Casala Carla, George Rani E, Kieran Mark W, Cheung Nai-Kong V, Ríos José, Gershon Timothy R, Suñol Mariona, Rodríguez Eva, Mayol Gemma, Garcia Idoia, de Torres Carmen, Mora Jaume, Lavarino Cinzia   +14 more
openaire   +4 more sources

Neuron-specific characteristics of miR135b- and miR137-mediated translational regulation

, 2021
microRNAs are small, non-coding post-transcriptional regulators of gene expression that target specific mRNAs, typically effecting translational repression coupled to degradation.
Karishma Joshi (10795382)
core   +1 more source

Neuron-specific protein interactions of Drosophila CASK-β are revealed by mass spectrometry [PDF]

Frontiers in Molecular Neuroscience, 2014
Modular scaffolding proteins are designed to have multiple interactors. CASK, a member of the membrane-associated guanylate kinase (MAGUK) superfamily, has been shown to have roles in many tissues, including neurons and epithelia. It is likely that the set of proteins it interacts with is different in each of these diverse tissues.
Konark eMukherjee, Konark eMukherjee, Justin B. eSlawson, Justin B. eSlawson, Bethany L. eChristmann, Leslie C Griffith   +5 more
openaire   +3 more sources

An intersectional gene regulatory strategy defines subclass diversity of C. elegans motor neurons

eLife, 2017
A core principle of nervous system organization is the diversification of neuron classes into subclasses that share large sets of features but differ in select traits. We describe here a molecular mechanism necessary for motor neurons to acquire subclass-
Paschalis Kratsios, Sze Yen Kerk, Catarina Catela, Joseph Liang, Berta Vidal, Emily A Bayer, Weidong Feng, Estanisla Daniel De La Cruz, Laura Croci, G Giacomo Consalez, Kota Mizumoto, Oliver Hobert   +11 more
doaj   +1 more source

A computational screen for site selective A-to-I editing detects novel sites in neuron specific Hu proteins

BMC Bioinformatics, 2010
Background Several bioinformatic approaches have previously been used to find novel sites of ADAR mediated A-to-I RNA editing in human. These studies have discovered thousands of genes that are hyper-edited in their non-coding intronic regions ...
Furey Terrence S, Wang Bei, Lundin Daniel, Åkerborg Örjan, Ensterö Mats, Öhman Marie, Lagergren Jens   +6 more
doaj   +1 more source

Biomarker potential of brain‐secreted extracellular vesicles in blood in Alzheimer's disease

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2020
Introduction Brain cells secrete extracellular microvesicles (EVs) that cross the blood‐brain barrier. Involved in cell‐to‐cell communication, EVs contain surface markers and a biologically active cargo of molecules specific to their tissue (and cell) of
AmanPreet Badhwar, Arsalan S. Haqqani
doaj   +1 more source

Neuron-specific expression of transmembrane protein 130 (TMEM130)

Scientific Reports
Transmembrane protein 130 (TMEM130) was identified as significantly downregulated in rupture-prone intracranial aneurysm lesions in a rat model. This study aimed to characterize TMEM130 tissue distribution and physiological function in rats. RNA sequencing was conducted on rupture-prone intracranial aneurysm lesions and control arterial tissues to ...
Tomomichi, Kayahara, Masahiko, Itani, Hiroki, Kurita, Tomohiro, Aoki   +3 more
openaire   +2 more sources