Results 11 to 20 of about 9,342,488 (306)

Cytokines and neuron-specific proteins in pediatric viral encephalitis and convulsive syndrome. I. Viral encephalitis [PDF]

Инфекция и иммунитет, 2020
Convulsive syndrome in children is manifested in the three forms: febrile convulsions in acute infections, symptomatic convulsions during acute neuroinfection, as well as onset of epilepsy requiring careful differentiation to prescribe adequate therapy ...
L. A. Alekseeva, G. F. Zheleznikova, E. Y. Gorelik, N. V. Skripchenko, A. A. Zhirkov   +4 more
doaj   +2 more sources

The Involvement of Neuron-Specific Factors in Dendritic Spinogenesis: Molecular Regulation and Association with Neurological Disorders [PDF]

Neural Plasticity, 2016
Dendritic spines are the location of excitatory synapses in the mammalian nervous system and are neuron-specific subcellular structures essential for neural circuitry and function. Dendritic spine morphology is determined by the F-actin cytoskeleton.
Hsiao-Tang Hu, Pu-Yun Shih, Yu-Tzu Shih, Yi-Ping Hsueh   +3 more
doaj   +2 more sources

Neuron-specific Agrin splicing by Nova RNA-binding proteins regulates conserved neuromuscular junction development in chordates.

PLoS Biology
In mammals, neuromuscular synapses rely on clustering of acetylcholine receptors (AChRs) in the muscle plasma membrane, ensuring optimal stimulation by motor neuron-released acetylcholine neurotransmitter.
Md Faruk Hossain, Sydney Popsuj, Burcu Vitrinel, Nicole A Kaplan, Alberto Stolfi, Lionel Christiaen, Matteo Ruggiu   +6 more
doaj   +2 more sources

Neuronal RNA processing: cross-talk between transcriptional regulation and RNA-binding proteins [PDF]

Frontiers in Molecular Neuroscience
In the nervous system, alternative RNA processing is particularly prevalent, which results in the expression of thousands of transcript variants found in no other tissue.
Hasan Can Ozbulut, Hasan Can Ozbulut, Hasan Can Ozbulut, Valérie Hilgers   +3 more
doaj   +4 more sources

Enhanced nigrostriatal neuron-specific, long-term expression by using neural-specific promoters in combination with targeted gene transfer by modified helper virus-free HSV-1 vector particles [PDF]

BMC Neuroscience, 2008
Background Direct gene transfer into neurons has potential for developing gene therapy treatments for specific neurological conditions, and for elucidating neuronal physiology.
Kong Lingxin, Wang Xiaodan, Zhang Guo-rong, Cao Haiyan, Geller Alfred I   +4 more
doaj   +3 more sources

CRISPR-mediated induction of neuron-enriched mitochondrial proteins boosts direct glia-to-neuron conversion. [PDF]

, 2021
Astrocyte-to-neuron conversion is a promising avenue for neuronal replacement therapy. Neurons are particularly dependent on mitochondrial function, but how well mitochondria adapt to the new fate is unknown.
Masserdotti, Giacomo, Breunig, C., Götz, Magdalena, Bulli, G., Masserdotti, G., Schmitt, Sabine, Merl-Pham, J., Russo, Gianluca L., Schmitt, S., Giehrl-Schwab, Jessica, Jastroch, M., Jastroch, Martin, Giesert, F., Wurst, Wolfgang, Giesert, Florian, Hauck, Stefanie M., Sonsalla, Giovanna, Zischka, Hans, Natarajan, Poornemaa, Hauck, S., Jastroch, Martin,, Natarajan, P., Sonsalla, G., Götz, M., Wurst, W., Russo, G., Goetz, M., Russo, G.L., Merl-Pham, Juliane, Hauck, S.M., Bulli, Giorgia, Stricker, S.H., Goetz, Magdalena, Breunig, Christopher T., Giehrl-Schwab, J., Zischka, H., Stricker, Stefan H., Stricker, S.   +37 more
core   +1 more source

Survival motor neuron protein modulates neuron-specific apoptosis [PDF]

Proceedings of the National Academy of Sciences, 2000
Spinal muscular atrophy (SMA) is attributed to mutations in the SMN1 gene, leading to loss of spinal cord motor neurons. The neurotropic Sindbis virus vector system was used to investigate a role for the survival motor neuron (SMN) protein in regulating neuronal apoptosis.
D A, Kerr, J P, Nery, R J, Traystman, B N, Chau, J M, Hardwick   +4 more
openaire   +2 more sources

The agrin gene codes for a family of basal lamina proteins that differ in function and distribution [PDF]

, 1992
We isolated two cDNAs that encode isoforms of agrin, the basal lamina protein that mediates the motor neuron-induced aggregation of acetylcholine receptors on muscle fibers at the neuromuscular junction.
Tsim, K. W., McMahan, U. J., Escher, G., Gensch, Erin M., Tsim, Karl W.K., Escher, Gérard, Kroger, S., Kröger, Stephan, Horton, Sharon E., Ruegg, M. A., Tsim, Karl W. K., Horton, S. E., Gensch, E. M., Ruegg, Markus A.   +13 more
core   +1 more source

Specific expression of channelrhodopsin-2 in single neurons of Caenorhabditis elegans [PDF]

, 2012
Optogenetic approaches using light-activated proteins like Channelrhodopsin-2 (ChR2) enable investigating the function of populations of neurons in live Caenorhabditis elegans (and other) animals, as ChR2 expression can be targeted to these cells using ...
Gottschalk, Alexander, Christian Schultheis (140316), Alexander Gottschalk (129613), Liewald, Jana F., Schultheis, Christian, Husson, Steven J., Cornelia Schmitt (140312), Steven J. Husson (140318), Schmitt, Cornelia, Jana F. Liewald (140319), Husson Steven J., Gottschalk Alexander, Steven J Husson, Schultheis Christian, Alexander Gottschalk, Navin Pokala, Jana F Liewald, Schmitt Cornelia, Cornelia I Bargmann, Christian Schultheis, Liewald Jana F., Cornelia Schmitt   +21 more
core   +2 more sources

Human brain proteins showing neuron‐specific interactions with γ‐secretase [PDF]

The FEBS Journal, 2015
The transmembrane protease complex γ‐secretase is a key enzyme in Alzheimer disease pathogenesis as it liberates the neurotoxic amyloid β‐peptide (Aβ); however, the mechanism of regulation of its activity in various cell types and subcellular compartments is largely unknown.
Mitsuhiro, Inoue, Ji-Yeun, Hur, Takahiro, Kihara, Yasuhiro, Teranishi, Natsuko G, Yamamoto, Taizo, Ishikawa, Birgitta, Wiehager, Bengt, Winblad, Lars O, Tjernberg, Sophia, Schedin-Weiss   +9 more
openaire   +2 more sources