Results 1 to 10 of about 241,573 (119)

Interactions of LINE-1 ORF1p with proteins and chromatin suggest a role in neuronal physiology [PDF]

Life Science Alliance
ORF1p, a LINE-1-encoded protein, regulates chromatin accessibility, neuron-specific gene expression, and neurite morphology in post-mitotic neurons, revealing a physiological role for this retrotransposon protein in the brain.
Sandra Sinnassamy, Olivia Massiani Beaudoin, Berangère Lombard, Damarys Loew, Tom Bonnifet, Magali Fradet, Héloïse Monnet, Thomas Caille, Nicolas Servant, Rajiv L Joshi, Julia Fuchs   +10 more
doaj   +2 more sources

Neuron‐derived extracellular vesicles contain synaptic proteins, promote spine formation, activate TrkB‐mediated signalling and preserve neuronal complexity

Journal of Extracellular Vesicles, 2023
Extracellular vesicles (EVs) play an important role in intercellular communication as carriers of signalling molecules such as bioactive miRNAs, proteins and lipids.
Julia Solana‐Balaguer, Genís Campoy‐Campos, Núria Martín‐Flores, Leticia Pérez‐Sisqués, Laia Sitjà‐Roqueta, Melike Kucukerden, Ana Gámez‐Valero, Albert Coll‐Manzano, Eulàlia Martí, Esther Pérez‐Navarro, Jordi Alberch, Jordi Soriano, Mercè Masana, Cristina Malagelada   +13 more
doaj   +1 more source

Toward Development of Neuron Specific Transduction After Systemic Delivery of Viral Vectors

Frontiers in Neurology, 2021
Widespread transduction of the CNS with a single, non-invasive systemic injection of adeno-associated virus is now possible due to the creation of blood-brain barrier-permeable capsids.
Dylan J. Finneran, Ikenna P. Njoku, Diego Flores-Pazarin, Meghana R. Ranabothu, Kevin R. Nash, David Morgan, Marcia N. Gordon   +6 more
doaj   +1 more source

Guidance receptor degradation is required for neuronal connectivity in the Drosophila nervous system. [PDF]

PLoS Biology, 2010
Axon pathfinding and synapse formation rely on precise spatiotemporal localization of guidance receptors. However, little is known about the neuron-specific intracellular trafficking mechanisms that underlie the sorting and activity of these receptors ...
W Ryan Williamson, Taehong Yang, Jonathan R Terman, P Robin Hiesinger   +3 more
doaj   +1 more source

SYNGR4 and PLEKHB1 deregulation in motor neurons of amyotrophic lateral sclerosis models: potential contributions to pathobiology

Neural Regeneration Research, 2022
Amyotrophic lateral sclerosis is the most common adult-onset neurodegenerative disease affecting motor neurons. Its defining feature is progressive loss of motor neuron function in the cortex, brainstem, and spinal cord, leading to paralysis and death ...
Rita F Marques, Kent E Duncan
doaj   +1 more source

The expression and significance of neuronal iconic proteins in podocytes.

PLoS ONE, 2014
Growing evidence suggests that there are many common cell biological features shared by neurons and podocytes; however, the mechanism of podocyte foot process formation remains unclear. Comparing the mechanisms of process formation between two cell types
Yu Sun, Hongxia Zhang, Ruimin Hu, Jianyong Sun, Xing Mao, Zhonghua Zhao, Qi Chen, Zhigang Zhang   +7 more
doaj   +1 more source

Human Dermal Fibroblasts Demonstrate Positive Immunostaining for Neuron- and Glia- Specific Proteins.

PLoS ONE, 2015
In stem cell cultures from adult human tissue, undesirable contamination with fibroblasts is frequently present. The presence of fibroblasts obscures the actual number of stem cells and may result in extracellular matrix production after transplantation.
C J Janmaat, K E de Rooij, H Locher, S C de Groot, J C M J de Groot, J H M Frijns, M A Huisman   +6 more
doaj   +1 more source

Splicing factors control C. elegans behavioural learning in a single neuron by producing DAF-2c receptor

Nature Communications, 2016
Little is known about the molecular mechanisms regulating neuron-specific alternative splicing. Here, the authors identify a combination of RNA-binding proteins regulating neuron-specific expression of the C.
Masahiro Tomioka, Yasuki Naito, Hidehito Kuroyanagi, Yuichi Iino   +3 more
doaj   +1 more source

CELF family RNA-binding protein UNC-75 regulates two sets of mutually exclusive exons of the unc-32 gene in neuron-specific manners in Caenorhabditis elegans. [PDF]

PLoS Genetics, 2013
An enormous number of alternative pre-mRNA splicing patterns in multicellular organisms are coordinately defined by a limited number of regulatory proteins and cis elements.
Hidehito Kuroyanagi, Yohei Watanabe, Masatoshi Hagiwara   +2 more
doaj   +1 more source

Intricate effects of primary motor neuronopathy on contractile proteins and metabolic muscle enzymes as revealed by label-free mass spectrometry

Bioscience Reports, 2014
While the long-term physiological adaptation of the neuromuscular system to changed functional demands is usually reflected by unilateral skeletal muscle transitions, the progressive degeneration of distinct motor neuron populations is often associated ...
Ashling Holland, Thomas Schmitt‑John, Paul Dowling, Paula Meleady, Michael Henry, Martin Clynes, Kay Ohlendieck   +6 more
doaj   +1 more source