Results 31 to 40 of about 1,818,525 (389)
Which Neurons Will Be the Engram - Activated Neurons and/or More Excitable Neurons? [PDF]
Experimental Neurobiology, 2016 During past decades, the formation and storage principle of memory have received much attention in the neuroscience field. Although some studies have attempted to demonstrate the nature of the engram, elucidating the memory engram allocation mechanism was not possible because of the limitations of existing methods, which cannot specifically modulate ...
Ji-il Kim +3 more
openaire +3 more sources
Human iPSC co-culture model to investigate the interaction between microglia and motor neurons
Scientific Reports, 2022 Motor neuron diseases such as amyotrophic lateral sclerosis are primarily characterized by motor neuron degeneration with additional involvement of non-neuronal cells, in particular, microglia.
Björn F. Vahsen +13 more
doaj +1 more source
Neuron-to-neuron α-synuclein propagation in vivo is independent of neuronal injury [PDF]
Acta Neuropathologica Communications, 2015 Interneuronal propagation of α-synuclein has been demonstrated in a variety of experimental models and may be involved in disease progression during the course of human synucleinopathies. The aim of this study was to assess the role that neuronal injury or, vice versa, cell integrity could have in facilitating interneuronal α-synuclein transfer and ...
Ulusoy, Ayse +6 more
openaire +4 more sources
Cell Reports, 2016 In spinal muscular atrophy, a neurodegenerative disease caused by ubiquitous deficiency in the survival motor neuron (SMN) protein, sensory-motor synaptic dysfunction and increased excitability precede motor neuron (MN) loss.
Christian M. Simon +5 more
doaj +1 more source
Molecular Brain, 2021 Parkinson’s disease (PD) is a multi-system neurodegenerative disorder. Patients with PD often suffer chronic pain. In the present study, we investigated motor, sensory and emotional changes in three different PD mice models.
Zhaoxiang Zhou +13 more
doaj +1 more source
Defective axonal transport in motor neuron disease [PDF]
, 2007 Several recent studies have highlighted the role of axonal transport in the pathogenesis of motor neuron diseases. Mutations in genes that control microtubule regulation and dynamics have been shown to cause motor neuron degeneration in mice and in a ...
Baas +77 more
core +1 more source
Molecular Brain, 2017 Excitatory synaptic transmission in central synapses is modulated by serotonin (5-HT). The anterior cingulate cortex (ACC) is an important cortical region for pain perception and emotion.
Zhen Tian +4 more
doaj +1 more source
Modeled channel distributions explain extracellular recordings from cultured neurons sealed to microelectrodes [PDF]
, 2002 Amplitudes and shapes of extracellular recordings from single neurons cultured on a substrate embedded microelectrode depend not only on the volume conducting properties of the neuron-electrode interface, but might also depend on the distribution of ...
Buitenweg, Jan Reinoud +2 more
core +3 more sources
Molecular Brain, 2020 Neuronal progenitor cells (NPC) play an essential role in homeostasis of the central nervous system (CNS). Considering their ability to differentiate into specific lineages, their manipulation and control could have a major therapeutic impact for those ...
Matteo Manzati +3 more
doaj +1 more source