Results 31 to 40 of about 1,288,895 (361)
Neuron-to-neuron α-synuclein propagation in vivo is independent of neuronal injury [PDF]
Acta Neuropathologica Communications, 2015 Interneuronal propagation of α-synuclein has been demonstrated in a variety of experimental models and may be involved in disease progression during the course of human synucleinopathies. The aim of this study was to assess the role that neuronal injury or, vice versa, cell integrity could have in facilitating interneuronal α-synuclein transfer and ...
Ulusoy, Ayse +6 more
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Human iPSC co-culture model to investigate the interaction between microglia and motor neurons
Scientific Reports, 2022 Motor neuron diseases such as amyotrophic lateral sclerosis are primarily characterized by motor neuron degeneration with additional involvement of non-neuronal cells, in particular, microglia.
Björn F. Vahsen +13 more
doaj +1 more source
Transcriptional Reprogramming of Distinct Peripheral Sensory Neuron Subtypes after Axonal Injury
Neuron, 2019 Primary somatosensory neurons are specialized to transmit specific types of sensory information through differences in cell size, myelination, and the expression of distinct receptors and ion channels, which together define their transcriptional and ...
William Renthal +7 more
semanticscholar +1 more source
Molecular Brain, 2020 Neuronal progenitor cells (NPC) play an essential role in homeostasis of the central nervous system (CNS). Considering their ability to differentiate into specific lineages, their manipulation and control could have a major therapeutic impact for those ...
Matteo Manzati +3 more
doaj +1 more source
Molecular Brain, 2017 Excitatory synaptic transmission in central synapses is modulated by serotonin (5-HT). The anterior cingulate cortex (ACC) is an important cortical region for pain perception and emotion.
Zhen Tian +4 more
doaj +1 more source
Nature Communications, 2023 Spinal muscular atrophy is an autosomal recessive neuromuscular disease caused by mutations in the multifunctional protein Survival of Motor Neuron, or SMN.
Shaqraa Musawi +15 more
doaj +1 more source
Physica A: Statistical Mechanics and its Applications, 2023 21 pages, 32 figures. A preprint of a work submitted to a scientific journal (first revision)
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Disease Models & Mechanisms, 2021 Spinocerebellar ataxia 3 (SCA3, also known as Machado–Joseph disease) is a neurodegenerative disease caused by inheritance of a CAG repeat expansion within the ATXN3 gene, resulting in polyglutamine (polyQ) repeat expansion within the ataxin-3 protein ...
Katherine J. Robinson +7 more
doaj +1 more source
Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss
Nature Neuroscience, 2019 Pericytes are positioned between brain capillary endothelial cells, astrocytes and neurons. They degenerate in multiple neurological disorders. However, their role in the pathogenesis of these disorders remains debatable.
A. Nikolakopoulou +15 more
semanticscholar +1 more source