Results 41 to 50 of about 257,577 (143)
Spermidine treatment: induction of autophagy but also apoptosis?
Molecular BrainMachado-Joseph disease (MJD), also known as spinocerebellar ataxia type 3, is a fatal neurodegenerative disease that causes loss of balance and motor co-ordination, eventually leading to paralysis.
Maxinne Watchon +7 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2021 The past decade has seen a rapid acceleration in the discovery of new genetic causes of ALS, with more than 20 putative ALS-causing genes now cited. These genes encode proteins that cover a diverse range of molecular functions, including free radical ...
Flora Cheng +28 more
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Neuron segmentation using 3D wavelet integrated encoder-decoder network [PDF]
arXiv, 2021 Motivation: 3D neuron segmentation is a key step for the neuron digital reconstruction, which is essential for exploring brain circuits and understanding brain functions. However, the fine line-shaped nerve fibers of neuron could spread in a large region, which brings great computational cost to the neuron segmentation. Meanwhile, the strong noises and
arxiv
Functional importance of noise in neuronal information processing [PDF]
EPL 124, 50001 (2018), 2018 Noise is an inherent part of neuronal dynamics, and thus of the brain. It can be observed in neuronal activity at different spatiotemporal scales, including in neuronal membrane potentials, local field potentials, electroencephalography, and magnetoencephalography.
arxiv +1 more source
Leader neurons in leaky integrate and fire neural network simulations [PDF]
arXiv, 2010 Several experimental studies show the existence of leader neurons in population bursts of 2D living neural networks. A leader neuron is, basically, a neuron which fires at the beginning of a burst (respectively network spike) more often that we expect by looking at its whole mean neural activity.
arxiv
Information processing at single neuron level [PDF]
arXiv, 2008 Based on numerical simulation of Hodgkin and Huxley type neuron stimulated from many synaptic inputs, an abstract concept of signal processing in individual neuron is proposed. In the concept proposed, neuron performs binding of synaptic inputs into a single output event, based on the degree of temporal coherence between the inputs.
arxiv
Neurological Research and PracticeObjective Robotic arms are innovative assistive devices for ALS patients with progressive motor deficits of arms and hands. The objective was to explore the patients´ expectations towards a robotic arm system and to assess the actual experiences after ...
Susanne Spittel +18 more
doaj +1 more source
ALS-associated mutant FUS induces selective motor neuron degeneration through toxic gain of function
Nature Communications, 2016 The mechanism by which FUS mutations cause familial ALS remains unclear. Here, the authors use mouse transgenic models to show that a toxic gain-of-function underlies motor neuron degeneration, and that the toxicity of mutant FUS does not depend on a ...
Aarti Sharma +9 more
doaj +1 more source
Bursting and Synchrony in Networks of Model Neurons [PDF]
R. Tetzlaff and C. E. Elger and K. Lehnertz (2013), Recent
Advances in Predicting and Preventing Epileptic Seizures, page 108-116,
Singapore, World Scientific, 2016 Bursting neurons are considered to be a potential cause of over-excitability and seizure susceptibility. The functional influence of these neurons in extended epileptic networks is still poorly understood. There is mounting evidence that the dynamics of neuronal networks is influenced not only by neuronal and synaptic properties but also by network ...
arxiv
Biomedical Papers, 2019 Aims: Optimal ECG monitoring in detecting recurrences of atrial fibrillation (AF) or atrial tachycardia (AT) after catheter ablation has not been well established.
Jan Chovancik +7 more
doaj +1 more source