Results 41 to 50 of about 1,209,467 (344)

Characterization of the anticipated synchronization regime in the coupled FitzHugh--Nagumo model for neurons [PDF]

open access: yes, 2002
We characterize numerically the regime of anticipated synchronization in the coupled FitzHugh-Nagumo model for neurons. We consider two neurons, coupled unidirectionally (in a master-slave configuration), subject to the same random external forcing and ...
Ballard   +20 more
core   +2 more sources

Neuronal Polarity [PDF]

open access: yesCold Spring Harbor Perspectives in Biology, 2009
The assembly of functional neuronal networks in the developing animal relies on the polarization of neurons, i.e., the formation of a single axon and multiple dendrites. Breaking the symmetry of neurons depends on cytoskeletal rearrangements. In particular, axon specification requires local dynamic instability of actin and stabilization of microtubules.
Tahirovic, S., Bradke, F.
openaire   +3 more sources

Dual roles of anterior cingulate cortex neurons in pain and pleasure in adult mice

open access: yesMolecular Brain, 2018
Human and animal studies indicate that some brain regions are activated during painful and pleasant situations, such as the anterior cingulate cortex (ACC).
Jing-Shan Lu   +4 more
doaj   +1 more source

Flow cytometry allows rapid detection of protein aggregates in cellular and zebrafish models of spinocerebellar ataxia 3

open access: yesDisease Models & Mechanisms, 2021
Spinocerebellar ataxia 3 (SCA3, also known as Machado–Joseph disease) is a neurodegenerative disease caused by inheritance of a CAG repeat expansion within the ATXN3 gene, resulting in polyglutamine (polyQ) repeat expansion within the ataxin-3 protein ...
Katherine J. Robinson   +7 more
doaj   +1 more source

A statistical model for in vivo neuronal dynamics [PDF]

open access: yes, 2014
Single neuron models have a long tradition in computational neuroscience. Detailed biophysical models such as the Hodgkin-Huxley model as well as simplified neuron models such as the class of integrate-and-fire models relate the input current to the ...
Pfister, Jean-Pascal   +1 more
core   +7 more sources

Output Stream of Binding Neuron with Feedback

open access: yes, 2007
The binding neuron model is inspired by numerical simulation of Hodgkin-Huxley-type point neuron, as well as by the leaky integrate-and-fire model. In the binding neuron, the trace of an input is remembered for a fixed period of time after which it ...
Vidybida, Alexander K.
core   +2 more sources

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

open access: yesFEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

I, NEURON: the neuron as the collective [PDF]

open access: yes, 2017
Purpose – In the last half-century, individual sensory neurons have been bestowed with characteristics of the whole human being, such as behavior and its oft-presumed precursor, consciousness. This anthropomorphization is pervasive in the literature.
Nizami, Lance
core  

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

open access: yesFEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro   +2 more
wiley   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

open access: yesFEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

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