Results 1 to 10 of about 5,245,598 (349)
Lymphocyte‐Activation Gene 3 Facilitates Pathological Tau Neuron‐to‐Neuron Transmission [PDF]
Advanced ScienceThe spread of prion‐like protein aggregates is a common driver of pathogenesis in various neurodegenerative diseases, including Alzheimer's disease (AD) and related Tauopathies.
Chan Chen +29 more
doaj +2 more sources
Rbfox1 Regulates Synaptic Transmission through the Inhibitory Neuron-Specific vSNARE Vamp1
Neuron, 2018 Summary Dysfunction of the neuronal RNA binding protein RBFOX1 has been linked to epilepsy and autism spectrum disorders. Rbfox1 loss in mice leads to neuronal hyper-excitability and seizures, but the physiological basis for this is unknown.
Chia-Ho Lin, Douglas L Black, Ji-Ann Lee
exaly +2 more sources
Information transmission in a neuron-astrocyte coupled model. [PDF]
PLoS ONE, 2013 A coupled model containing two neurons and one astrocyte is constructed by integrating Hodgkin-Huxley neuronal model and Li-Rinzel calcium model. Based on this hybrid model, information transmission between neurons is studied numerically.
Jun Tang, Jin-Ming Luo, Jun Ma
doaj +4 more sources
Cell Reports, 2019 Summary: The proinflammatory cytokine interleukin-17 (IL-17) is implicated in pain regulation. However, the synaptic mechanisms by which IL-17 regulates pain transmission are unknown.
Hao Luo +7 more
doaj +3 more sources
eLife, 2021 The necessity and functional significance of neurotransmitter co-transmission remains unclear. The glutamatergic ‘KNDy’ neurons co-express kisspeptin, neurokinin B (NKB), and dynorphin and exhibit a highly stereotyped synchronized behavior that reads out
Xinhuai Liu +7 more
doaj +1 more source
Characterization of multiscale logic operations in the neural circuits
Frontiers in Bioscience-Landmark, 2021 Background: Ever since the seminal work by McCulloch and Pitts, the theory of neural computation and its philosophical foundation known as ‘computationalism’ have been central to brain-inspired artificial intelligence (AI) technologies. The present study
JunHyuk Woo +4 more
doaj +1 more source
Editorial: Neuronal Co-transmission [PDF]
Frontiers in Neural Circuits, 2019 This work was supported by Byggmastare Olle Engkvist foundation and Major Gosta Linds foundation (ES), and from National Institute of Neurological Disease and Stroke Grant NS029436 (MN), Canadian Institutes of Health Research and the Brain Canada (Multi-Investigator Research Initiative) and Krembil Foundations (L-ET), Consejo Nacional de Ciencia y ...
Apergis-Schoute, J +6 more
openaire +5 more sources
Bio-Protocol, 2023 Synapses provide the main route of signal transduction within neuronal networks. Many factors regulate critical synaptic functions. These include presynaptic calcium channels, triggering neurotransmitter release, and postsynaptic ionotropic receptors ...
Ruslan Stanika, Gerald Obermair
doaj +1 more source
Neuron, 2020 SUMMARY Substantia nigra dopamine neurons have been implicated in the initiation and invigoration of movement, presumably through their modulation of striatal projection neuron (SPN) activity.
Asha K. Lahiri, M. D. Bevan
semanticscholar +1 more source
Cell Reports, 2020 Summary: Recent studies have revealed an essential role for embryonic cortical development in the pathophysiology of neurodevelopmental disorders, including autism spectrum disorder (ASD).
Ke Zhang +21 more
doaj +1 more source