Results 31 to 40 of about 5,245,598 (349)

Recombinant BDNF rescues deficits in basal synaptic transmission and hippocampal LTP in BDNF knockout mice.

Neuron, 1996
Brain-derived neurotrophic factor (BDNF) is expressed at high levels in hippocampal neurons, and its expression is modulated by neural activity. Knockout mice can be used to study the roles of molecules like BDNF in synaptic plasticity with more ...
Susan L. Patterson, T. Abel, T. A. Deuel, Kelsey C. Martin, Jack C Rose, E. Kandel   +5 more
semanticscholar   +1 more source

Glutamate‐mediated neuronal–glial transmission

Journal of Anatomy, 2007
AbstractThe brain is the most complex organ of the human body. It is composed of several highly specialized and heterogeneous populations of cells, represented by neurones (e.g. motoneurons, projection neurons or interneurons), and glia represented by astrocytes, oligodendrocytes and microglia.
Verkhratsky, Alexei; id_orcid 0000-0003-2592-9898, Kirchhoff, Frank   +1 more
openaire   +5 more sources

Dopaminergic modulation of synaptic transmission in cortex and striatum

Neuron, 2012
Among the many neuromodulators used by the mammalian brain to regulate circuit function and plasticity, dopamine (DA) stands out as one of the most behaviorally powerful.
N. Tritsch, B. Sabatini
semanticscholar   +1 more source

In Vivo Measurement of Cell-Type-Specific Synaptic Connectivity and Synaptic Transmission in Layer 2/3 Mouse Barrel Cortex

Neuron, 2015
Summary Intracellular recordings of membrane potential in vitro have defined fundamental properties of synaptic communication. Much less is known about the properties of synaptic connectivity and synaptic transmission in vivo.
A. Pala, C. Petersen
semanticscholar   +1 more source

Regulation of Irregular Neuronal Firing by Autaptic Transmission [PDF]

Scientific Reports, 2016
AbstractThe importance of self-feedback autaptic transmission in modulating spike-time irregularity is still poorly understood. By using a biophysical model that incorporates autaptic coupling, we here show that self-innervation of neurons participates in the modulation of irregular neuronal firing, primarily by regulating the occurrence frequency of ...
Guo, Daqing, Wu, Shengdun, Chen, Mingming, Perc, Matjaž, Zhang, Yangsong, Ma, Jingling, Cui, Yan, Xu, Peng, Xia, Yang, Yao, Dezhong   +9 more
openaire   +4 more sources

Cdon ablation in motor neurons causes age‐related motor neuron degeneration and impaired sciatic nerve repair

Journal of Cachexia, Sarcopenia and Muscle, 2023
Background The functional deterioration and loss of motor neurons are tightly associated with degenerative motor neuron diseases and aging‐related muscle wasting.
Sunghee Kim, Subin An, Jinwoo Lee, Yideul Jeong, Chang‐Lim You, Hyebeen Kim, Ju‐Hyeon Bae, Chae‐Eun Yun, Dongryul Ryu, Gyu‐Un Bae, Jong‐Sun Kang   +10 more
doaj   +1 more source

Neurexins in serotonergic neurons regulate neuronal survival, serotonin transmission, and complex mouse behaviors

eLife, 2023
Extensive serotonin (5-hydroxytryptamine, 5-HT) innervation throughout the brain corroborates 5-HT’s modulatory role in numerous cognitive activities. Volume transmission is the major mode for 5-HT transmission but mechanisms underlying 5-HT signaling ...
Amy Cheung, Kotaro Konno, Yuka Imamura, Aya Matsui, Manabu Abe, Kenji Sakimura, Toshikuni Sasaoka, Takeshi Uemura, Masahiko Watanabe, Kensuke Futai   +9 more
doaj   +1 more source

Neuropeptide transmission in brain circuits

Neuron, 2012
Neuropeptides are found in many mammalian CNS neurons where they play key roles in modulating neuronal activity. In contrast to amino acid transmitter release at the synapse, neuropeptide release is not restricted to the synaptic specialization, and ...
A. N. van den Pol
semanticscholar   +1 more source

FMRP Regulates Neurotransmitter Release and Synaptic Information Transmission by Modulating Action Potential Duration via BK channels

Neuron, 2013
SUMMARY Loss of FMRP causes Fragile X syndrome (FXS), but the physiological functions of FMRP remain highly debatable. Here we show that FMRP regulates neurotransmitter release in CA3 pyramidal neurons by modulating action potential (AP) duration.
Pan-Yue Deng, Ziv Rotman, J. Blundon, Yongcheol Cho, Jianmin Cui, V. Cavalli, Stanislav S Zakharenko, V. Klyachko   +7 more
semanticscholar   +1 more source

The dopamine neuron synaptic map in the striatum

Cell Reports, 2023
Summary: Dopamine neurons project to the striatum to control movement, cognition, and motivation via slower volume transmission as well as faster dopamine, glutamate, and GABA synaptic actions capable of conveying the temporal information in dopamine ...
Nao Chuhma, Soo Jung Oh, Stephen Rayport
doaj   +1 more source