Results 21 to 30 of about 5,245,598 (349)

Dopamine Triggers the Maturation of Striatal Spiny Projection Neuron Excitability during a Critical Period

Neuron, 2018
SUMMARY Neural circuits are formed and refined during childhood, including via critical changes in neuronal excitability. Here, we investigated the ontogeny of striatal intrinsic excitability.
Ori J. Lieberman, Avery F McGuirt, E. Mosharov, Irena Pigulevskiy, Benjamin D. Hobson, Sejoon Choi, Micah D. Frier, E. Santini, A. Borgkvist, D. Sulzer   +9 more
semanticscholar   +1 more source

Spike timing-dependent plasticity under imbalanced excitation and inhibition reduces the complexity of neural activity

Frontiers in Computational Neuroscience, 2023
Excitatory and inhibitory neurons are fundamental components of the brain, and healthy neural circuits are well balanced between excitation and inhibition (E/I balance).
Jihoon Park, Jihoon Park, Yuji Kawai, Minoru Asada, Minoru Asada, Minoru Asada, Minoru Asada   +6 more
doaj   +1 more source

Neuroligin-4 regulates excitatory synaptic transmission in human neurons

Neuron, 2019
SUMMARY The autism-associated synaptic-adhesion gene Neuroligin-4 (NLGN4) is poorly conserved evolutionarily, limiting conclusions from Nlgn4 mouse models for human cells.
Samuele G. Marro, Soham Chanda, Nan Yang, Justyna A. Janas, Giulio Valperga, Justin H. Trotter, Bo Zhou, Sean A. Merrill, Issa Yousif, Hannah Shelby, H. Vogel, M. Kalani, T. Südhof, Marius Wernig   +13 more
semanticscholar   +1 more source

Accumbal Dopamine Release Tracks the Expectation of Dopamine Neuron-Mediated Reinforcement

Cell Reports, 2019
Summary: Dopamine (DA) transmission in the nucleus accumbens (NAc) facilitates cue-reward associations and appetitive action. Reward-related accumbal DA release dynamics are traditionally ascribed to ventral tegmental area (VTA) DA neurons. Activation of
Dan P. Covey, Joseph F. Cheer
doaj   +1 more source

Enhanced GABA transmission drives bradykinesia following loss of dopamine D2 receptor signaling

Neuron, 2016
Summary Bradykinesia is a prominent phenotype of Parkinson’s disease, depression, and other neurological conditions. Disruption of dopamine transmission plays an important role but progress in understanding the exact mechanisms driving slowness of ...
Julia C. Lemos, Danielle M. Friend, Alanna R. Kaplan, Jung H. Shin, M. Rubinstein, Alexxai V. Kravitz, Veronica A. Alvarez   +6 more
semanticscholar   +1 more source

Disrupting neuronal transmission: mechanism of DBS? [PDF]

Frontiers in Systems Neuroscience, 2014
Applying high-frequency stimulation (HFS) to deep brain structure, known as deep brain stimulation (DBS), has now been recognized an effective therapeutic option for a wide range of neurological and psychiatric disorders. DBS targeting the basal ganglia thalamo-cortical loop, especially the internal segment of the globus pallidus (GPi), subthalamic ...
Chiken, Satomi, Nambu, Atsushi
openaire   +3 more sources

Postingestive Modulation of Food Seeking Depends on Vagus-Mediated Dopamine Neuron Activity [PDF]

, 2020
Postingestive nutrient sensing can induce food preferences. However, much less is known about the ability of postingestive signals to modulate food-seeking behaviors.
Gerfen, Charles R., Alves da Silva, Joaquim, Oliveira-Maia, Albino J., Cui, Guohong, Almeida, Joana, Fernandes, Ana B., Costa, Rui M.   +6 more
core   +1 more source

"Self" versus "non-self" connectivity dictates properties of synaptic transmission and plasticity.

PLoS ONE, 2013
Autapses are connections between a neuron and itself. These connections are morphologically similar to "normal" synapses between two different neurons, and thus were long thought to have similar properties of synaptic transmission.
Huisheng Liu, Edwin R Chapman, Camin Dean   +2 more
doaj   +1 more source

IGF-1 Receptor Differentially Regulates Spontaneous and Evoked Transmission via Mitochondria at Hippocampal Synapses

Neuron, 2016
Summary The insulin-like growth factor-1 receptor (IGF-1R) signaling is a key regulator of lifespan, growth, and development. While reduced IGF-1R signaling delays aging and Alzheimer’s disease progression, whether and how it regulates information ...
Neta Gazit, I. Vertkin, I. Shapira, Martin S. Helm, Edden Slomowitz, Maayan Sheiba, Yael Mor, S. Rizzoli, I. Slutsky   +8 more
semanticscholar   +1 more source

Astrocytes in Neurodegenerative Diseases: A Perspective from Tauopathy and α-Synucleinopathy

Life, 2021
Neurodegenerative diseases are aging-associated chronic pathological conditions affecting primarily neurons in humans. Inclusion bodies containing misfolded proteins have emerged as a common pathologic feature for these diseases. In many cases, misfolded
Peng Wang, Yihong Ye
doaj   +1 more source