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Biochemical and Biophysical Research Communications, 2005
The tumor suppressor and transcription factor p53 is a key modulator of cellular stress responses, and activation of p53 can trigger apoptosis in many cell types including neurons. Apoptosis is a form of programmed cell death that occurs in neurons during development of the nervous system and may also be responsible for neuronal deaths that occur in ...
Carsten, Culmsee, Mark P, Mattson
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The tumor suppressor and transcription factor p53 is a key modulator of cellular stress responses, and activation of p53 can trigger apoptosis in many cell types including neurons. Apoptosis is a form of programmed cell death that occurs in neurons during development of the nervous system and may also be responsible for neuronal deaths that occur in ...
Carsten, Culmsee, Mark P, Mattson
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Neuronal Apoptosis in Neurodegeneration
Antioxidants & Redox Signaling, 2007Apoptosis mediates the precise and programmed natural death of neurons and is a physiologically important process in neurogenesis during maturation of the central nervous system. However, premature apoptosis and/or an aberration in apoptosis regulation is implicated in the pathogenesis of neurodegeneration, a multifaceted process that leads to various ...
Masahiro, Okouchi +3 more
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Evidence for neuronal apoptosis in pontosubicular neuron necrosis
Neuropathology and Applied Neurobiology, 1996Pontosubicular neuron necrosis (PSN) is characterized by acute neuronal death in the subiculum and the pons occurring in a circumscribed perinatal period. The morphological changes in PSN are quite similar to those described during apoptosis, a form of programmed cell death.
Y, Brück +3 more
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Kainate induces apoptosis in neurons
Neuroscience, 1996Growing evidence suggests that non-N-methyl-D-aspartate receptor activation may contribute to neuronal death in both acute and chronic neurological diseases. The intracellular processes that mediate this form of neuronal death are poorly understood. We have previously characterized a model of kainate neurotoxicity using cerebellar granule cell neurons ...
N A, Simonian +4 more
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The molecular mechanisms of neuronal apoptosis
Current Opinion in Neurobiology, 1994During the past year, apoptosis has been recognized as a process that is perpetually poised to be initiated--often from the cytoplasm rather than from the nucleus--unless it is suppressed by survival factors. Suspected mediators of apoptosis that have recently been investigated include the cysteine protease interleukin-1 beta-converting enzyme, free ...
L L, Rubin +3 more
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NeuroReport, 1998
Apoptosis is a controlled form of cell death involving cascades of degradative events. Proteolysis during apoptosis is largely due to the activity of a family of cysteine proteases called caspases. In recent years different roles for members of this family have been revealed.
A M, Gorman, S, Orrenius, S, Ceccatelli
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Apoptosis is a controlled form of cell death involving cascades of degradative events. Proteolysis during apoptosis is largely due to the activity of a family of cysteine proteases called caspases. In recent years different roles for members of this family have been revealed.
A M, Gorman, S, Orrenius, S, Ceccatelli
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Challenges in Neuronal Apoptosis
Current Alzheimer Research, 2006There are myriads of reasons and ways for a neuron to die, among which apoptosis is a specific form that is processed in two major signaling pathways, the TNF-receptor-mediated (extrinsic) and the mitochondria-based (intrinsic) cell death pathway with several avenues of crosstalk between them.
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Apoptosis in cultured hNT neurons
Developmental Brain Research, 2001Programmed cell death (apoptosis) is an important mechanism shaping the size of different cell populations within the developing nervous system. In our study we used the NT2/D1 clone originally established from the Ntera 2 cell line to investigate the baseline levels of apoptosis in cultured postmitotic hNT (NT2-N) neurons previously treated for 3, 4 ...
T, Zigova +8 more
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Acidosis reduces neuronal apoptosis
NeuroReport, 1998Acidosis is a well established concomitant of tissue ischemia. Acidosis in the pH range 6.0-7.0 is seen in cerebral ischemia and within solid tumors. Extracellular acidosis of pH 6.0 and 6.4 provided essentially complete protection from 48 h serum deprivation induced apoptotic death of cultured primary murine neurons.
L, Xu +3 more
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CYTOKINE-MEDIATED NEURONAL APOPTOSIS
Neurochemistry International, 1997Cytokines have been reported to induce neuronal injury via the free radical nitric oxide (NO); however, the precise mechanism underlying cytokine-mediated neurotoxicity is unclear. We investigated the hypothesis that cytokine-mediated neurotoxicity in primary cultures of human fetal neurons occurs via an apoptotic mechanism triggered by NO.
S, Hu, P K, Peterson, C C, Chao
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