Results 261 to 270 of about 1,037,185 (302)

Cracking the Code of Neuronal Apoptosis and Survival [PDF]

Cell Death and Disease, 2015
AbstractNeuronal apoptosis and survival are tightly controlled processes that regulate cell fate during the development of the central nervous system and its homeostasis throughout adulthood. A new study in primary cultures of cerebellar granule neurons identified common transcriptional cascades during rescue from apoptosis by insulin-like growth ...
Sebastiano Cavallaro
exaly   +4 more sources

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Bid regulation of neuronal apoptosis

Developmental Brain Research, 2001
Bid is a BH3 domain only pro-apoptotic member of the Bcl-2 family which interacts with Bax to regulate apoptosis. Bax-deficient embryos show decreased neuronal programmed cell death in vivo and resistance to cytosine arabinoside (AraC)-induced neuronal apoptosis in vitro.
J R, Leonard, C, D'Sa, B R, Cahn, S J, Korsmeyer, K A, Roth   +4 more
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Semaphorins as Mediators of Neuronal Apoptosis

Journal of Neurochemistry, 1999
Abstract : Shrinkage and collapse of the neuritic network are often observed during the process of neuronal apoptosis. However, the molecular and biochemical basis for the axonal damage associated with neuronal cell death is still unclear. We present evidence for the involvement of axon guidance molecules with repulsive cues in neuronal cell death ...
A, Shirvan, I, Ziv, G, Fleminger, R, Shina, Z, He, I, Brudo, E, Melamed, A, Barzilai   +7 more
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The neuronal apoptosis inhibitory protein suppresses neuronal differentiation and apoptosis in PC12 cells

Human Molecular Genetics, 2000
The human neuronal apoptosis inhibitory protein (NAIP) gene has been discovered as a candidate gene for spinal muscular atrophy, a genetic disorder characterized by motor neuron loss in the spinal cord. The telomeric NAIP gene on human chromosome 5 is deleted together with survival motor neurons (SMN) in many cases of the most severe forms of the ...
R, Götz, C, Karch, M R, Digby, J, Troppmair, U R, Rapp, M, Sendtner   +5 more
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Involvement of caspases in sympathetic neuron apoptosis

Journal of Cell Science, 1997
ABSTRACT In order to study the involvement of caspases in neuronal cell death, we have examined the effects of the viral caspase inhibitor p35 and peptide caspase inhibitors on sympathetic neurons isolated from the superior cervical ganglion (SCG).
M J, McCarthy, L L, Rubin, K L, Philpott
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Neuronal migration, apoptosis and bipolar disorder

Revista de Psiquiatría y Salud Mental (English Edition), 2012
Bipolar disorder, like the majority of psychiatric disorders, is considered a neurodevelopment disease of neurodevelopment. There is an increased rate of neuronal birth and death during this development period. In the particular case of the processes that determine neuronal death, it is known that those neurons that establish connections have to be ...
Ezequiel, Uribe, Richard, Wix
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Oxidative Stress: Apoptosis in Neuronal Injury

Current Alzheimer Research, 2006
Apoptosis has been well documented to play a significant role in cell loss during neurodegenerative disorders, such as stroke, Parkinson disease, and Alzheimer's disease. In addition, reactive oxygen species (ROS) has been implicated in the cellular damage during these neurodegenerative disorders.
Kok Poh, Loh, Shan Hong, Huang, Ranil, De Silva, Benny K H, Tan, Yi Zhun, Zhu   +4 more
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Attenuation of Cortical Neuronal Apoptosis by Gangliosides

The Journal of Pharmacology and Experimental Therapeutics, 1999
Addition of the natural gangliosides monosialoganglioside (GM1), disialoganglioside, trisialoganglioside, or tetrasialoganglioside in the range of 10 to 100 microM, but not asialoganglioside lacking the sialic acid moiety, attenuated cortical neuronal apoptosis induced by serum deprivation, ionomycin, or cyclosporin A but not by protein kinase ...
B R, Ryu, D W, Choi, D M, Hartley, E, Costa, I, Jou, B J, Gwag   +5 more
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Ischemia-induced neuronal apoptosis

Current Opinion in Neurobiology, 1996
Hypoxic-ischemic neuronal death has long been considered to represent necrosis, but it now appears that many brain neurons undergo apoptosis after either global or focal ischemic insults. This event is probably substantially distinct from ischemia-triggered excitotoxicity, which tends to produce necrosis.
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Effects of docosapentaenoic acid on neuronal apoptosis

Lipids, 2003
AbstractWe previously established that n−3 FA status in membrane phospholipids influences the biosynthesis and accumulation of PS in neuronal tissues. We also demonstrated that neuronal apoptosis under adverse conditions is prevented by DHA enrichment in a PS‐dependent manner.
Hee-Yong, Kim, Mohammed, Akbar, Audrey, Lau   +2 more
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