Results 271 to 280 of about 1,037,185 (302)
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Pentobarbital inhibits apoptosis in neuronal cells
Critical Care Medicine, 2000Previous reports have demonstrated that barbiturates have a protective effect against cerebral ischemia, although the mechanisms are incompletely understood. Recently, it has been suggested that apoptosis is involved in ischemic neuronal death. This study examined the effect of pentobarbital on neuronal apoptosis.Randomized, controlled, prospective ...
Y, Morimoto +6 more
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The Role of HSPA12B in Regulating Neuronal Apoptosis
Neurochemical Research, 2013Heat shock protein A12B (HSPA12B) is the newest member of a recently defined subfamily of proteins distantly related to the 70-kDa family of heat shock proteins (HSP70) family. HSP70s play a crucial role in protecting cells, tissues, organs and animals from various noxious conditions.
Lihua, Kang +9 more
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A role for synGAP in regulating neuronal apoptosis
European Journal of Neuroscience, 2005AbstractThe brain‐specific Ras/Rap GTPase‐activating protein synGAP is a major component of the postsynaptic density at glutamatergic synapses. It is a target for phosphorylation by Ca2+/calmodulin‐dependent protein kinase II, which up‐regulates its GTPase‐activating activity.
Knuesel, Irene +4 more
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Regulation of PTEN expression in neuronal apoptosis
Molecular Brain Research, 1999PTEN phosphatase is a tumor suppressor gene that dephosphorylates phosphatidylinositol phosphates. PTEN restrains the function of a major antiapoptotic and survival pathway involving phosphoinositide 3-kinase and Akt kinase. Our purpose was to find out whether apoptotic inducers affect the expression of PTEN in cerebellar granule neurons and ...
S, Kyrylenko +3 more
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Kainic acid induces apoptosis in neurons
Neuroscience, 1996Growing evidence suggests that non-N-methyl-D-aspartate receptor activation may contribute to neuronal death in both acute and chronic neurological diseases. The intracellular processes that mediate this form of neuronal death are poorly understood.
N A, Simonian +4 more
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Genetic determinants of neuronal vulnerability to apoptosis
Cellular and Molecular Life Sciences, 2012Apoptosis is a common mode of cell death that contributes to neuronal loss associated with neurodegeneration. Single-nucleotide polymorphisms (SNPs) in chromosomal DNA are contributing factors dictating natural susceptibility of humans to disease. Here, the most common SNPs affecting neuronal vulnerability to apoptosis are reviewed in the context of ...
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[Neuronal development and apoptosis].
Human cell, 1994There are several distinct mechanisms of neuronal cell death that occurs during development. Nuclear type of cell death involves cell shrinkage and chromatin condensation both typical of apoptosis. Here in this short review we summarize some recent advances concerning the mechanism of nuclear type of neuronal death in vitro.
T, Koike, S, Tanaka, E, Ito
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Neurofibromin and Neuronal Apoptosis
2003Abstract : Our purpose is to examine the role of neurofibromin in modulating the survival of embryonic sensory and sympathetic neurons. To understand how reduced neurofibromin levels might impact the survival responses to activity-mediated signaling (mimicked with KCl) and to neurotrophins, we used dissociated cultures of Nf1+/- and exon23a-/- sensory ...
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The p75 neurotrophin receptor and neuronal apoptosis
Progress in Neurobiology, 2000Although evidence continues to accumulate for the apoptosis-inducing role of the p75 neurotrophin receptor, several outstanding questions remain. One of these concerns the signal transduction pathway of p75, which continues to be elusive. The evidence for the roles of ceramide, c-jun kinase and NF-kappaB is discussed: none of these are able to account ...
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