Results 71 to 80 of about 270,002 (292)

FOXP2 drives neuronal differentiation by interacting with retinoic acid signaling pathways

Frontiers in Cellular Neuroscience, 2014
FOXP2 was the first gene shown to cause a Mendelian form of speech and language disorder. Although developmentally expressed in many organs, loss of a single copy of FOXP2 leads to a phenotype that is largely restricted to orofacial impairment during ...
Paolo eDevanna, Jeroen eMiddelbeek, Sonja Catherine Vernes, Sonja Catherine Vernes   +3 more
doaj   +1 more source

Leptin Receptor Signaling Regulates Protein Synthesis Pathways and Neuronal Differentiation in Pluripotent Stem Cells [PDF]

, 2020
Manoj K. Gupta, Heidrun Vethe, Samir Softic, Tata Nageswara Rao, Vilas Wagh, Jun Shirakawa, Harald Barsnes, Marc Vaudel, Tomozumi Takatani, Sevim Kahraman, Masaji Sakaguchi, Rachael N. Martínez, Jiang‐Miao Hu, Yngvild Bjørlykke, Helge Ræder, Rohit Kulkarni   +15 more
openalex   +1 more source

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

A method for siRNA-mediated knockdown of target genes in RA-induced neurogenesis using P19 cells

MethodsX
This study presents a comprehensive protocol for siRNA-mediated knockdown in the differentiation of P19 cells into neuronal-like cells. Utilizing a retinoic acid (RA)-induced neurogenesis model, P19 cells were cultured under specific conditions that ...
Hossein Khodadadi, Hiroaki Taniguchi
doaj   +1 more source

The Dietary Flavonoid, Luteolin, Negatively Affects Neuronal Differentiation

Frontiers in Molecular Neuroscience, 2019
Luteolin, a polyphenolic plant flavonoid, has been attributed with numerous beneficial properties like anti-cancer, antioxidant, and anti-inflammatory action.
Amrutha Swaminathan, Amrutha Swaminathan, Moumita Basu, Abdelhamid Bekri, Abdelhamid Bekri, Pierre Drapeau, Pierre Drapeau, Tapas K. Kundu   +7 more
doaj   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Small Molecules Greatly Improve Conversion of Human-Induced Pluripotent Stem Cells to the Neuronal Lineage

Stem Cells International, 2012
Efficient in vitro differentiation into specific cell types is more important than ever after the breakthrough in nuclear reprogramming of somatic cells and its potential for disease modeling and drug screening.
Sally K. Mak, Y. Anne Huang, Shifteh Iranmanesh, Malini Vangipuram, Ramya Sundararajan, Loan Nguyen, J. William Langston, Birgitt Schüle   +7 more
doaj   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Overexpression of calbindin‐D _28K in hippocampal progenitor cells increases neuronal differentiation and neurite outgrowth [PDF]

, 2005
Ju Hee Kim, Jin‐A Lee, Young Mok Song, Chang‐Hwan Park, Se‐Jin Hwang, Yong‐Seok Kim, Bong‐Kiun Kaang, Hyeon Son   +7 more
openalex   +1 more source