Results 1 to 10 of about 137,338 (285)
Neurobiology of Disease, 2010 Lissencephaly–pachygyria-severe band heterotopia are diffuse neuronal migration disorders (NMDs) causing severe, global neurological impairment. Abnormalities of the LIS1, DCX, ARX, TUBA1A and RELN genes have been associated with these malformations ...
Renzo Guerrini, Elena Parrini
doaj +4 more sources
Reelin signaling in the migration of ventral brain stem and spinal cord neurons [PDF]
Frontiers in Cellular Neuroscience, 2016 The extracellular matrix protein Reelin is an important orchestrator of neuronal migration during the development of the central nervous system. While its role and mechanism of action have been extensively studied and reviewed in the formation of dorsal ...
Sandra eBlaess, Ankita Ravi Vaswani
doaj +3 more sources
Pediatric Neurology Briefs, 1991 Thirty patients with intractable partial epilepsy and a pathological or radiological diagnosis of neuronal migration disorders (NMD) were studied at the Montreal Neurological Institute and Hospital, Montreal, Quebec, Canada.
J Gordon Millichap
doaj +3 more sources
Neuronal migration and protein kinases [PDF]
Frontiers in Neuroscience, 2015 The formation of the six-layered structure of the mammalian cortex via the inside-out pattern of neuronal migration is fundamental to neocortical functions.
Toshio eOhshima
doaj +3 more sources
Neuronal Migration: How Do You Build a Brain? [PDF]
, 2015 Senior biology major Alex Burkard is working in the Walsh Neurodevelopment Laboratory at VCU to help answer the question, ‘How do you build a brain?’ Burkard is researching neuronal migration in Zebrafish and how cellular polarity affects hindbrain ...
Uppalapati, Sravya
core +3 more sources
Guiding Neuronal Cell Migrations [PDF]
Cold Spring Harbor Perspectives in Biology, 2010 Neuronal migration is, along with axon guidance, one of the fundamental mechanisms underlying the wiring of the brain. As other organs, the nervous system has acquired the ability to grow both in size and complexity by using migration as a strategy to position cell types from different origins into specific coordinates, allowing for the generation of ...
Marín Parra, Óscar +3 more
openaire +3 more sources
Brain Sciences, 2021 The 17p13.3 chromosome region is often deleted or duplicated in humans, resulting in severe neurodevelopmental disorders such as Miller–Dieker syndrome (MDS) and 17p13.3 duplication syndrome.
Xiaonan Liu +3 more
doaj +1 more source
Nucleokinesis in Neuronal Migration [PDF]
Neuron, 2005 Neuronal migration is a critical phase of nervous system development and can be divided into two distinct phases: extension of the leading process and movement of the cell body and nucleus (nucleokinesis). Nucleokinesis appears to require many of the same cytoskeletal and signaling molecules used in cell mitosis.
Tsai, Li-Huei, Gleeson, Joseph G.
openaire +2 more sources
Frontiers in Molecular Neuroscience, 2021 Radial neuronal migration is a key neurodevelopmental event indispensable for proper cortical laminar organization. Cortical neurons mainly use glial fiber guides, cell adhesion dynamics, and cytoskeletal remodeling, among other discrete processes, to ...
Godwin Sokpor +17 more
doaj +1 more source
Granule Cell Dispersion in Human Temporal Lobe Epilepsy: Proteomics investigation of neurodevelopmental migratory pathways [PDF]
, 2020 Granule cell dispersion (GCD) is a common pathological feature observed in the hippocampus of patients with Mesial Temporal Lobe Epilepsy (MTLE). Pathomechanisms underlying GCD remain to be elucidated, but one hypothesis proposes aberrant reactivation of
Al-Kaaby, B. +11 more
core +1 more source