Results 21 to 30 of about 85,596 (253)
Neuronal migration and its disorders affecting the CA3 region
Frontiers in Cellular Neuroscience, 2014 In this review, we focus on CA3 neuronal migration disorders in the rodent. We begin by introducing the main steps of hippocampal development, and we summarize characteristic hippocampal malformations in human.
Richard eBelvindrah +8 more
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Control of Neuronal Migration and Aggregation by Reelin Signaling in the Developing Cerebral Cortex
Frontiers in Cell and Developmental Biology, 2017 The mammalian cerebral neocortex has a well-organized laminar structure, achieved by the highly coordinated control of neuronal migration. During cortical development, excitatory neurons born near the lateral ventricle migrate radially to reach their ...
Yuki Hirota, Kazunori Nakajima
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Prenatal Events and CNS Migration Disorders
Pediatric Neurology Briefs, 1994 The role of pre-, peri-, and postnatal environmental factors and genetic predisposition in the genesis of neuronal migration disorders (NMD) in 40 patients with epilepsy was determined by standardized questionnaires at the Montreal Neurological Institute
J Gordon Millichap
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Lissencephaly with Congenital Hypothyroidism: A Case Report
Journal of Nepal Medical Association, 2022 Lissencephaly is a malformation of cortical development associated with deficient neuronal migration and abnormal formation of cerebral convolutions or gyri. The lissencephaly spectrum consists of agyria, pachygyria, and subcortical band heterotopia. At
Shambhu Kumar Sahani +3 more
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Pediatric Brain Maturation and Migration Disorders
Diagnostics, 2022 Neurodevelopmental disorders, including neuronal migration disorders, are best understood in the context of altered normal development. Neurons normally migrate from their site of origin to their (usually cortical) destination using a wide range of ...
Matthew J. Barkovich
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Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Pathogenesis of Börjeson-Forssman-Lehmann syndrome: Insights from PHF6 function
Neurobiology of Disease, 2016 Intellectual disability encompasses a large set of neurodevelopmental disorders of cognition that are more common in males than females. Although mutations in over 100 X-linked genes associated to intellectual disability have been identified, only a few ...
Arezu Jahani-Asl +3 more
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Interneuron odyssey: molecular mechanisms of tangential migration
Frontiers in Neural Circuits, 2023 Cortical GABAergic interneurons are critical components of neural networks. They provide local and long-range inhibition and help coordinate network activities involved in various brain functions, including signal processing, learning, memory and ...
Ikram Toudji +8 more
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Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Comparing the paths of Hedgehog release in artificial and natural settings
FEBS Letters, EarlyView.Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley +1 more source