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Science, 1959
An electronic model is described for simulating many of the gross operational functions which are believed to hold for living nerve cells. Synaptic growth is not included. Despite difficulties in drawing very rigorous analogies between the biological cell and its model, a sufficient number of rough similarities exist to make systemic experimentation ...
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An electronic model is described for simulating many of the gross operational functions which are believed to hold for living nerve cells. Synaptic growth is not included. Despite difficulties in drawing very rigorous analogies between the biological cell and its model, a sufficient number of rough similarities exist to make systemic experimentation ...
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2007
Biological tools that are unleashed in malignancies are employed in a controlled manner during neuronal development. By default, early embryonic cells would become neuronal stem cells, a path that is blocked by specific signaling pathways. The future nervous system only develops where this blockade is inhibited by inductive signals from the 'organizer'.
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Biological tools that are unleashed in malignancies are employed in a controlled manner during neuronal development. By default, early embryonic cells would become neuronal stem cells, a path that is blocked by specific signaling pathways. The future nervous system only develops where this blockade is inhibited by inductive signals from the 'organizer'.
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Scientific American, 1988
One tends to think of the nervous system in terms of chains of excitatory signals that tell neurons to fire. The signals that say "Don't fire" also have a major role. Inhibitory signals damp overall neural activity and also fine-tune the responses of particular circuits. The primary carrier of these signals is the inhibitory transmitter known as GABA.
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One tends to think of the nervous system in terms of chains of excitatory signals that tell neurons to fire. The signals that say "Don't fire" also have a major role. Inhibitory signals damp overall neural activity and also fine-tune the responses of particular circuits. The primary carrier of these signals is the inhibitory transmitter known as GABA.
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Current Opinion in Genetics & Development, 1992
Cell fate specification, a central problem in developmental biology, presents an intriguing challenge in the studies of neural development. How are certain cells in the embryonic ectoderm selected to be neuronal precursors? How do individual neuronal precursors and their progeny cells acquire their own identity?
Y N, Jan, L Y, Jan
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Cell fate specification, a central problem in developmental biology, presents an intriguing challenge in the studies of neural development. How are certain cells in the embryonic ectoderm selected to be neuronal precursors? How do individual neuronal precursors and their progeny cells acquire their own identity?
Y N, Jan, L Y, Jan
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Nature, 1980
More than 20 peptides have been identified in neurones of the brain, spinal cord and periphery. In several cases a peptide occurs together with a 'classical' transmitter in the same neurone. This raises new questions about the process of neurotransmission and may have important implications for our understanding and treatment of mental disorders.
T, Hökfelt +4 more
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More than 20 peptides have been identified in neurones of the brain, spinal cord and periphery. In several cases a peptide occurs together with a 'classical' transmitter in the same neurone. This raises new questions about the process of neurotransmission and may have important implications for our understanding and treatment of mental disorders.
T, Hökfelt +4 more
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Proceedings of the Royal Society of London. Series B: Biological Sciences, 1995
A recent letter to Nature (Vaadia et al. Nature, Lond. 373, 515-518 (1995)) presented compelling results concerning neuronal interactions in monkey cortex. Vaadia et al. made two fundamental points: (i) it is possible that cortical function is mediated by dynamic modulation of coherent firing among neurons; and (ii) these time-dependent changes in ...
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A recent letter to Nature (Vaadia et al. Nature, Lond. 373, 515-518 (1995)) presented compelling results concerning neuronal interactions in monkey cortex. Vaadia et al. made two fundamental points: (i) it is possible that cortical function is mediated by dynamic modulation of coherent firing among neurons; and (ii) these time-dependent changes in ...
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Angewandte Chemie International Edition in English, 1976
AbstractThe nervous system is made up of several kinds of cells which should ideally be examined separately in biochemical studies. Since we are not yet able to isolate the different kinds of cells, use is made of cell lines derived from a single cell which are isolated from tumors of the nervous system and which can be reproduced at will in the same ...
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AbstractThe nervous system is made up of several kinds of cells which should ideally be examined separately in biochemical studies. Since we are not yet able to isolate the different kinds of cells, use is made of cell lines derived from a single cell which are isolated from tumors of the nervous system and which can be reproduced at will in the same ...
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