Results 1 to 10 of about 2,486,433 (324)

Transfer of mitochondria from astrocytes to neurons after stroke

Nature, 2016
Neurons can release damaged mitochondria and transfer them to astrocytes for disposal and recycling. This ability to exchange mitochondria may represent a potential mode of cell-to-cell signalling in the central nervous system.
K. Hayakawa, E. Esposito, Xiaohua Wang, Y. Terasaki, Yi Liu, Changhong Xing, X. Ji, E. Lo   +7 more
semanticscholar   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Using the Optical Fractionator to Estimate Total Cell Numbers in the Normal and Abnormal Developing Human Forebrain

Frontiers in Neuroanatomy, 2017
Human fetal brain development is a complex process which is vulnerable to disruption at many stages. Although histogenesis is well-documented, only a few studies have quantified cell numbers across normal human fetal brain growth. Due to the present lack
Karen B. Larsen, Karen B. Larsen
doaj   +1 more source

Data-driven modeling of the olfactory neural codes and their dynamics in the insect antennal lobe [PDF]

, 2013
Recordings from neurons in the insects' olfactory primary processing center, the antennal lobe (AL), reveal that the AL is able to process the input from chemical receptors into distinct neural activity patterns, called olfactory neural codes.
Kutz, J. Nathan, Riffell, Jeffrey A., Shlizerman, Eli   +2 more
core   +3 more sources

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

nNOS(+) striatal neurons, a subpopulation spared in Huntington's Disease, possess functional NMDA receptors but fail to generate mitochondrial ROS in response to an excitotoxic challenge. [PDF]

, 2013
Huntington's disease (HD) is a neurodegenerative condition characterized by severe neuronal loss in the cortex and striatum that leads to motor and behavioral deficits.
Canzoniero, Lorella MT, Choi, Dennis W, Dugan, Laura L, Granzotto, Alberto, Sensi, Stefano L, Turetsky, Dorothy M   +5 more
core   +2 more sources

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Astrocyte-secreted factors modulate synaptic protein synthesis as revealed by puromycin labeling of isolated synaptosomes

Frontiers in Molecular Neuroscience
The synaptic proteome can be shaped by proteins transported from the neuronal soma and/or by mRNAs that are delivered to synapses where proteins are locally synthesized. This last mechanism is known as local translation.
Aida de la Cruz-Gambra, Aida de la Cruz-Gambra, Jimena Baleriola, Jimena Baleriola   +3 more
doaj   +1 more source

Classical Transient Receptor Potential 1 (TRPC1): Channel or Channel Regulator?

Cells, 2014
In contrast to other Classical Transient Receptor Potential TRPC channels the function of TRPC1 as an ion channel is a matter of debate, because it is often difficult to obtain substantial functional signals over background in response to over-expression
Alexander Dietrich, Meike Fahlbusch, Thomas Gudermann   +2 more
doaj   +1 more source

Microwave neural processing and broadcasting with spintronic nano-oscillators

, 2018
Can we build small neuromorphic chips capable of training deep networks with billions of parameters? This challenge requires hardware neurons and synapses with nanometric dimensions, which can be individually tuned, and densely connected.
Araujo, F. Abreu, Bortolotti, P., Cros, V., Ernoult, M., Fukushima, A., Grollier, J., Hirtzlin, T., Kubota, H., Locatelli, N., Querlioz, D., Romera, M., Talatchian, P., Trastoy, J., Tsunegi, S., Vodenicarevic, D., Yakushiji, K., Yuasa, S.   +16 more
core   +1 more source