Results 21 to 30 of about 2,030,886 (349)
Sexually dimorphic microRNA miR-190 regulates lifespan in male Drosophila
RNA Biology, 2022 microRNAs are short noncoding RNAs that buffer fluctuations in gene expression in a myriad of physiological conditions. Here, we carried out a screen to identify the role of microRNAs in the maintenance of age-dependent neuronal functions in adult ...
Jervis Fernandes, Jishy Varghese
doaj +1 more source
Origins of choice-related activity in mouse somatosensory cortex. [PDF]
, 2015 During perceptual decisions about faint or ambiguous sensory stimuli, even identical stimuli can produce different choices. Spike trains from sensory cortex neurons can predict trial-to-trial variability in choice.
Kwon, Sung E +3 more
core +2 more sources
Neuronal activity regulates neurotransmitter switching in the adult brain following light-induced stress. [PDF]
, 2018 Neurotransmitter switching in the adult mammalian brain occurs following photoperiod-induced stress, but the mechanism of regulation is unknown. Here, we demonstrate that elevated activity of dopaminergic neurons in the paraventricular nucleus of the ...
Deisseroth, Karl +4 more
core +1 more source
Role of Keratinocytes in Sensitive Skin
Frontiers in Medicine, 2019 Sensitive skin is a clinical syndrome defined by the occurrence of unpleasant sensations such as burning, stinging, tingling, pricking, or itching in response to various normally innocuous physical, chemical, and thermal stimuli.
Matthieu Talagas +3 more
doaj +1 more source
Scientific Validation of Human Neurosphere Assays for Developmental Neurotoxicity Evaluation
Frontiers in Toxicology, 2022 There is a call for a paradigm shift in developmental neurotoxicity (DNT) evaluation, which demands the implementation of faster, more cost-efficient, and human-relevant test systems than current in vivo guideline studies.
Katharina Koch +10 more
doaj +1 more source
Single-protein detection in crowded molecular environments in cryo-EM images
eLife, 2017 We present an approach to study macromolecular assemblies by detecting component proteins’ characteristic high-resolution projection patterns, calculated from their known 3D structures, in single electron cryo-micrographs.
J Peter Rickgauer +2 more
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Genomic Analysis of Drosophila Neuronal Remodeling: A Role for the RNA-Binding Protein Boule as a Negative Regulator of Axon Pruning [PDF]
, 2008 Drosophila mushroom body (MB) {gamma} neurons undergo axon pruning during metamorphosis through a process of localized degeneration of specific axon branches.
Hoopfer, Eric D. +3 more
core +1 more source
Neuron Merging: Compensating for Pruned Neurons
CoRR, 2020 NeurIPS ...
Woojeong Kim +3 more
openaire +3 more sources
Virology Journal, 2011 Background The NS1 protein of influenza A virus is able to bind with many proteins that affect cellular signal transduction and protein synthesis in infected cells.
Xu Yanxuan +7 more
doaj +1 more source
Neural Regeneration Research, 2015 Studies have shown that exercise interventions can improve functional recovery after spinal cord injury, but the mechanism of action remains unclear. To investigate the mechanism, we established a unilateral corticospinal tract injury model in rats by ...
Ting-ting Hou +5 more
doaj +1 more source