Results 21 to 30 of about 1,189,995 (318)

Single-protein detection in crowded molecular environments in cryo-EM images

eLife, 2017
We present an approach to study macromolecular assemblies by detecting component proteins’ characteristic high-resolution projection patterns, calculated from their known 3D structures, in single electron cryo-micrographs.
J Peter Rickgauer, Nikolaus Grigorieff, Winfried Denk   +2 more
doaj   +1 more source

The distinct binding properties between avian/human influenza A virus NS1 and Postsynaptic density protein-95 (PSD-95), and inhibition of nitric oxide production

Virology Journal, 2011
Background The NS1 protein of influenza A virus is able to bind with many proteins that affect cellular signal transduction and protein synthesis in infected cells.
Xu Yanxuan, Chen Xiaoxuan, Zhang Chi, Su Yun, Wang Gefei, Li Weizhong, Zhang Heng, Li Kangsheng   +7 more
doaj   +1 more source

Electrophysiological differences between specialized and multifunctional turtle spinal cord neurons involved in scratching and swimming motor patterns

, 2023
I examined the electrophysiology of both multifunctional and specialized neurons located in the turtle spinal cord, which are activated during swimming, scratching, and/or flexion reflex.
Morris, Madison
core  

Exercise promotes motor functional recovery in rats with corticospinal tract injury: anti-apoptosis mechanism

Neural Regeneration Research, 2015
Studies have shown that exercise interventions can improve functional recovery after spinal cord injury, but the mechanism of action remains unclear. To investigate the mechanism, we established a unilateral corticospinal tract injury model in rats by ...
Ting-ting Hou, Xiao-yu Yang, Peng Xia, Su Pan, Jian Liu, Zhi-ping Qi   +5 more
doaj   +1 more source

Exciting inhibition in primates

eLife, 2020
A new genetic marker enables precise control over a group of inhibitory neurons in monkeys.
Wim Vanduffel, Xiaolian Li
doaj   +1 more source

Directing astroglia from the cerebral cortex into subtype specific functional neurons [PDF]

, 2010
Astroglia from the postnatal cerebral cortex can be reprogrammed in vitro to generate neurons following forced expression of neurogenic transcription factors, thus opening new avenues towards a potential use of endogenous astroglia for brain repair ...
Gascón, Sergio, Masserdotti, Giacomo, Timm Schroeder, Götz, Magdalena, Heinrich Christophe, Gascón Sergio, Masserdotti, G., Tiedt Steffen, Berninger, Benedikt, Tiedt, Steffen, Schroeder, Timm, Christophe Heinrich, Sánchez Rodrigo, Magdalena Götz, Blum Robert, Schroeder Timm, Gascón, S., Götz Magdalena, Berninger, B., Tripathi Pratibha, Steffen Tiedt, Tripathi, P., Heinrich, Christophe, Giacomo Masserdotti, Götz, M., Tiedt, S., Sánchez, Rodrigo, Sánchez, R., Blum, Robert, Tripathi, Pratibha, Pratibha Tripathi, Berninger Benedikt, Heinrich, C., Benedikt Berninger, Blum, R., Masserdotti Giacomo, Rodrigo Sánchez, Robert Blum, Sergio Gascón, Schroeder, T.   +39 more
core   +1 more source

Competing Interactions of RNA-Binding Proteins, MicroRNAs, and Their Targets Control Neuronal Development and Function

Biomolecules, 2015
Post-transcriptional mechanisms play critical roles in the control of gene expression during neuronal development and maturation as they allow for faster responses to environmental cues and provide spatially-restricted compartments for local control of ...
Amy S. Gardiner, Jeffery L. Twiss, Nora I. Perrone-Bizzozero   +2 more
doaj   +1 more source

Graphene-Derived Materials Interfacing the Spinal Cord: Outstanding in Vitro and in Vivo Findings

Frontiers in Systems Neuroscience, 2017
The attractiveness of graphene-derived materials (GDMs) for neural applications has fueled their exploration as components of biomaterial interfaces contacting the brain and the spinal cord.
Ana Domínguez-Bajo, Ankor González-Mayorga, Elisa López-Dolado, Elisa López-Dolado, María C. Serrano, María C. Serrano, María C. Serrano   +6 more
doaj   +1 more source

Modulation of Neuronal Interactions Through Neuronal Synchronization [PDF]

Science, 2007
Brain processing depends on the interactions between neuronal groups. Those interactions are governed by the pattern of anatomical connections and by yet unknown mechanisms that modulate the effective strength of a given connection. We found that the mutual influence among neuronal groups depends on the phase relation between rhythmic activities within
Womelsdorf, T., Schoffelen, J., Oostenveld, R., Singer, W., Desimone, R., Engel, A., Fries, P.   +6 more
openaire   +4 more sources

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source