Results 11 to 20 of about 1,033,935 (249)

Human interictal epileptiform discharges are bidirectional traveling waves echoing ictal discharges

eLife, 2022
Interictal epileptiform discharges (IEDs), also known as interictal spikes, are large intermittent electrophysiological events observed between seizures in patients with epilepsy.
Elliot H Smith, Jyun-you Liou, Edward M Merricks, Tyler Davis, Kyle Thomson, Bradley Greger, Paul House, Ronald G Emerson, Robert Goodman, Guy M McKhann, Sameer Sheth, Catherine Schevon, John D Rolston   +12 more
doaj   +1 more source

Sex determination gene transformer regulates the male-female difference in Drosophila fat storage via the adipokinetic hormone pathway

eLife, 2021
Sex differences in whole-body fat storage exist in many species. For example, Drosophila females store more fat than males. Yet, the mechanisms underlying this sex difference in fat storage remain incompletely understood. Here, we identify a key role for
Lianna W Wat, Zahid S Chowdhury, Jason W Millington, Puja Biswas, Elizabeth J Rideout   +4 more
doaj   +1 more source

Sexually dimorphic microRNA miR-190 regulates lifespan in male Drosophila

RNA Biology, 2022
microRNAs are short noncoding RNAs that buffer fluctuations in gene expression in a myriad of physiological conditions. Here, we carried out a screen to identify the role of microRNAs in the maintenance of age-dependent neuronal functions in adult ...
Jervis Fernandes, Jishy Varghese
doaj   +1 more source

Role of Keratinocytes in Sensitive Skin

Frontiers in Medicine, 2019
Sensitive skin is a clinical syndrome defined by the occurrence of unpleasant sensations such as burning, stinging, tingling, pricking, or itching in response to various normally innocuous physical, chemical, and thermal stimuli.
Matthieu Talagas, Matthieu Talagas, Laurent Misery, Laurent Misery   +3 more
doaj   +1 more source

Scientific Validation of Human Neurosphere Assays for Developmental Neurotoxicity Evaluation

Frontiers in Toxicology, 2022
There is a call for a paradigm shift in developmental neurotoxicity (DNT) evaluation, which demands the implementation of faster, more cost-efficient, and human-relevant test systems than current in vivo guideline studies.
Katharina Koch, Kristina Bartmann, Julia Hartmann, Julia Kapr, Jördis Klose, Eliška Kuchovská, Melanie Pahl, Kevin Schlüppmann, Etta Zühr, Ellen Fritsche, Ellen Fritsche   +10 more
doaj   +1 more source

Single-protein detection in crowded molecular environments in cryo-EM images

eLife, 2017
We present an approach to study macromolecular assemblies by detecting component proteins’ characteristic high-resolution projection patterns, calculated from their known 3D structures, in single electron cryo-micrographs.
J Peter Rickgauer, Nikolaus Grigorieff, Winfried Denk   +2 more
doaj   +1 more source

The distinct binding properties between avian/human influenza A virus NS1 and Postsynaptic density protein-95 (PSD-95), and inhibition of nitric oxide production

Virology Journal, 2011
Background The NS1 protein of influenza A virus is able to bind with many proteins that affect cellular signal transduction and protein synthesis in infected cells.
Xu Yanxuan, Chen Xiaoxuan, Zhang Chi, Su Yun, Wang Gefei, Li Weizhong, Zhang Heng, Li Kangsheng   +7 more
doaj   +1 more source

Exercise promotes motor functional recovery in rats with corticospinal tract injury: anti-apoptosis mechanism

Neural Regeneration Research, 2015
Studies have shown that exercise interventions can improve functional recovery after spinal cord injury, but the mechanism of action remains unclear. To investigate the mechanism, we established a unilateral corticospinal tract injury model in rats by ...
Ting-ting Hou, Xiao-yu Yang, Peng Xia, Su Pan, Jian Liu, Zhi-ping Qi   +5 more
doaj   +1 more source

Exciting inhibition in primates

eLife, 2020
A new genetic marker enables precise control over a group of inhibitory neurons in monkeys.
Wim Vanduffel, Xiaolian Li
doaj   +1 more source

Competing Interactions of RNA-Binding Proteins, MicroRNAs, and Their Targets Control Neuronal Development and Function

Biomolecules, 2015
Post-transcriptional mechanisms play critical roles in the control of gene expression during neuronal development and maturation as they allow for faster responses to environmental cues and provide spatially-restricted compartments for local control of ...
Amy S. Gardiner, Jeffery L. Twiss, Nora I. Perrone-Bizzozero   +2 more
doaj   +1 more source