Results 41 to 50 of about 2,597,556 (387)
Single-protein detection in crowded molecular environments in cryo-EM images
eLife, 2017 We present an approach to study macromolecular assemblies by detecting component proteins’ characteristic high-resolution projection patterns, calculated from their known 3D structures, in single electron cryo-micrographs.
J Peter Rickgauer +2 more
doaj +1 more source
A Transgenic Rat for Investigating the Anatomy and Function of Corticotrophin Releasing Factor Circuits. [PDF]
, 2015 Corticotrophin-releasing factor (CRF) is a 41 amino acid neuropeptide that coordinates adaptive responses to stress. CRF projections from neurons in the central nucleus of the amygdala (CeA) to the brainstem are of particular interest for their role in ...
Blasio, Angelo +13 more
core +2 more sources
Direct conversion of fibroblasts to functional neurons by defined factors
Nature, 2010 Cellular differentiation and lineage commitment are considered to be robust and irreversible processes during development. Recent work has shown that mouse and human fibroblasts can be reprogrammed to a pluripotent state with a combination of four ...
Thomas Vierbuchen +5 more
semanticscholar +1 more source
Spinally projecting preproglucagon axons preferentially innervate sympathetic preganglionic neurons [PDF]
, 2014 Glucagon-like peptide-1 (GLP-1) affects central autonomic neurons, including those controlling the cardiovascular system, thermogenesis, and energy balance.
Gribble, FM +5 more
core +2 more sources
Mammalian Neuronal mRNA Transport Complexes: The Few Knowns and the Many Unknowns
Frontiers in Integrative Neuroscience, 2021 Hundreds of messenger RNAs (mRNAs) are transported into neurites to provide templates for the assembly of local protein networks. These networks enable a neuron to configure different cellular domains for specialized functions.
Elsa C. Rodrigues +5 more
doaj +1 more source
Neurons other than motor neurons in motor neuron disease.
Histology and histopathology, 2017 Amyotrophic lateral sclerosis (ALS) is typically defined by a loss of motor neurons in the central nervous system. Accordingly, morphological analysis for decades considered motor neurons (in the cortex, brainstem and spinal cord) as the neuronal population selectively involved in ALS.
Ruffoli R +7 more
openaire +6 more sources
What drives progressive motor deficits in patients with acute pontine infarction?
Neural Regeneration Research, 2015 Progressive motor deficits are relatively common in acute pontine infarction and frequently associated with increased functional disability. However, the factors that affect the progression of clinical motor weakness are largely unknown. Previous studies
Jue-bao Li +6 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2020 Neurons derived from human induced pluripotent stem cells (hiPSC-derived neurons) offer novel opportunities for the development of preclinical models of human neurodegenerative diseases (NDDs).
Pedro Mateos-Aparicio +2 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2021 The purinergic 2X7 (P2X7) receptor expressed in satellite glial cells (SGCs) is involved in the inflammatory response, and transient receptor potential vanilloid 1 (TRPV1) participates in the process of neurogenic inflammation, such as that in diabetic ...
Anhui Wang +6 more
doaj +1 more source