Results 61 to 70 of about 2,030,886 (349)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Neurons with stereotyped and rapid responses provide a reference frame for relative temporal coding in primate auditory cortex [PDF]

, 2012
The precise timing of spikes of cortical neurons relative to stimulus onset carries substantial sensory information. To access this information the sensory systems would need to maintain an internal temporal reference that reflects the precise stimulus ...
Brasselet, Romain, Kayser, Christoph, Logothetis, Nikos, Logothetis, Nikos K., Panzeri, Stefano   +4 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Upper Limit on the Thermodynamic Information Content of an Action Potential

Frontiers in Computational Neuroscience, 2020
In computational neuroscience, spiking neurons are often analyzed as computing devices that register bits of information, with each action potential carrying at most one bit of Shannon entropy.
Sterling Street
doaj   +1 more source

Artificial Neurons with Arbitrarily Complex Internal Structures

, 2001
Artificial neurons with arbitrarily complex internal structure are introduced. The neurons can be described in terms of a set of internal variables, a set activation functions which describe the time evolution of these variables and a set of ...
Kohring, G. A.
core   +2 more sources

Involvement of ras p2I in Neurotrophin-induced Response of Sensory, but Not Sympathetic Neurons [PDF]

, 1993
Little is known about the signal transduction mechanisms involved in the response to neurotrophins and other neurotrophic factors in neurons, beyond the activation of the tyrosine kinase activity of the neurotrophin receptors belonging to the trk family.
Barde, Y. A., Borasio, Gian Domenico, Heumann, R., Markus, A., Wittinghofer, A.   +4 more
core   +3 more sources

I, NEURON: the neuron as the collective [PDF]

Kybernetes, 2017
Purpose In the last half-century, individual sensory neurons have been bestowed with characteristics of the whole human being, such as behavior and its oft-presumed precursor, consciousness. This anthropomorphization is pervasive in the literature. It is also absurd, given what we know about neurons, and it needs to be abolished.
openaire   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Prefrontal gamma oscillations and fear extinction learning require early postnatal interneuron-oligodendroglia communication

Nature Communications
Emerging evidence links oligodendrocyte (OL) lineage cells and myelin to cognitive processes, yet the role of myelination in shaping neuronal networks critical for cognitive tasks remains unknown.
Fabrice Plaisier, Cristóbal Ibaceta-González, Hasni Khelfaoui, Adrianne E. S. Watson, Corinne Poilbout, Anastassia Voronova, María Cecilia Angulo   +6 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source