Results 51 to 60 of about 1,189,995 (318)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Developmental Regulation of Small-Conductance Ca²⁺-Activated K⁺ Channel Expression and Function in Rat Purkinje Neurons

, 2002
Calcium transients play an important role in the early and later phases of differentiation and maturation of single neurons and neuronal networks. Small-conductance calcium-activated potassium channels of the SK type modulate membrane excitability and ...
Stocker, M, Pedarzani P., Stocker, M., Pedarzani, P, Cingolani, L., Cingolani L, Gymnopoulos, M., Boccaccio, A, Cingolani, L. A., Gymnopoulos M, Boccaccio A, Gymnopoulos, Marco, Boccaccio, A., Cingolani, LA, Gymnopoulos, M, Pedarzani, P., Stocker M   +16 more
core   +1 more source

Functional properties of neurons derived from in vitro reprogrammed postnatal astroglia [PDF]

, 2007
With the exception of astroglia-like cells in the neurogenic niches of the telencephalic subependymal or hippocampal subgranular zone, astroglia in all other regions of the adult mouse brain do not normally generate neurons.
Costa, Marcos R., Sutor, B., Götz, M., Götz, Magdalena, Grothe, B., Sutor, Bernd, Berninger, Benedikt, Schroeder, Timm, Costa, M.R., Grothe, Benedikt, Koch, Ursula, Berninger, B., Schroeder, T., Koch, U.   +13 more
core   +1 more source

Astrocyte-secreted factors modulate synaptic protein synthesis as revealed by puromycin labeling of isolated synaptosomes

Frontiers in Molecular Neuroscience
The synaptic proteome can be shaped by proteins transported from the neuronal soma and/or by mRNAs that are delivered to synapses where proteins are locally synthesized. This last mechanism is known as local translation.
Aida de la Cruz-Gambra, Aida de la Cruz-Gambra, Jimena Baleriola, Jimena Baleriola   +3 more
doaj   +1 more source

Classical Transient Receptor Potential 1 (TRPC1): Channel or Channel Regulator?

Cells, 2014
In contrast to other Classical Transient Receptor Potential TRPC channels the function of TRPC1 as an ion channel is a matter of debate, because it is often difficult to obtain substantial functional signals over background in response to over-expression
Alexander Dietrich, Meike Fahlbusch, Thomas Gudermann   +2 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Propofol Anesthesia Impairs the Maturation and Survival of Adult-born Hippocampal Neurons

, 2013
BACKGROUND:: Adult neurogenesis occurs in the hippocampus of most mammals, including humans, and plays an important role in hippocampal-dependent learning. This process is highly regulated by neuronal activity and might therefore be vulnerable to
Krzisch, M., Demeter, K., Toni, Nicolas, Sultan, S., Sandell, J., Vutskits, László, Demeter, Kornél, Sultan, Sébastien, Toni, N., Krzisch, Marine, Sandell, Julie, Vutskits, L.   +11 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Pharmacogenetic stimulation of cholinergic pedunculopontine neurons reverses motor deficits in a rat model of Parkinson's disease [PDF]

, 2015
Background Patients with advanced Parkinson's disease (PD) often present with axial symptoms, including postural- and gait difficulties that respond poorly to dopaminergic agents.
Pienaar, Ilse, De Paola, V, Gretenkord, Sabine, David Dexter (3572210), Sabine Gretenkord, Withers, Dominic, Ilse Pienaar (4504357), Dominic Withers (3572216), Gartside, Sarah, De Paola, Vincenzo, Puneet Sharma, Ilse S. Pienaar, Puneet Sharma (3572222), Sharma, Puneet, Dominic Withers, Sabine Gretenkord (3572213), David T. Dexter, Vincenzo De Paola, Joanna L. Elson, Ilse Pienaar (3572219), Joanna L Elson (16036517), Sarah Gartside (3572225), Dexter, David, Elson, Joanna, Sarah E. Gartside, Joanna Elson (271089), Vincenzo De Paola (275215), Sarah E Gartside (16264538), David T Dexter (9237410)   +28 more
core   +1 more source

Upper Limit on the Thermodynamic Information Content of an Action Potential

Frontiers in Computational Neuroscience, 2020
In computational neuroscience, spiking neurons are often analyzed as computing devices that register bits of information, with each action potential carrying at most one bit of Shannon entropy.
Sterling Street
doaj   +1 more source