Results 51 to 60 of about 1,334,435 (305)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Mammalian Neuronal mRNA Transport Complexes: The Few Knowns and the Many Unknowns

Frontiers in Integrative Neuroscience, 2021
Hundreds of messenger RNAs (mRNAs) are transported into neurites to provide templates for the assembly of local protein networks. These networks enable a neuron to configure different cellular domains for specialized functions.
Elsa C. Rodrigues, Julia Grawenhoff, Sebastian J. Baumann, Nicola Lorenzon, Sebastian P. Maurer, Sebastian P. Maurer   +5 more
doaj   +1 more source

Neurons other than motor neurons in motor neuron disease.

Histology and histopathology, 2017
Amyotrophic lateral sclerosis (ALS) is typically defined by a loss of motor neurons in the central nervous system. Accordingly, morphological analysis for decades considered motor neurons (in the cortex, brainstem and spinal cord) as the neuronal population selectively involved in ALS.
Ruffoli R, Biagioni F, Busceti CL, Gaglione A, Ryskalin L, Gambardella S, Frati A, Fornai F.   +7 more
openaire   +5 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

A simple Hidden Markov Model for midbrain dopaminergic neurons [PDF]

, 2009
Poster presentation: Introduction Dopaminergic neurons in the midbrain show a variety of firing patterns, ranging from very regular firing pacemaker cells to bursty and irregular neurons.
Gerhard, Felipe, Roeper, Jochen, Felipe Gerhard, Schneider, Gaby, Gaby Schneider, Schiemann, Julia, Jochen Roeper, Julia Schiemann   +7 more
core   +1 more source

Analyzing Autoencoder-Based Intrusion Detection System Performance

Journal of Information Security and Cybercrimes Research, 2023
The rise in cyberattacks targeting critical network infrastructure has spurred an increased emphasis on the development of robust cybersecurity measures.
Seiba Alhassan, Gaddafi Abdul-Salaam, Michael Asante, Yaw Missah, Ernest Ganaa   +4 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Astrocyte-secreted factors modulate synaptic protein synthesis as revealed by puromycin labeling of isolated synaptosomes

Frontiers in Molecular Neuroscience
The synaptic proteome can be shaped by proteins transported from the neuronal soma and/or by mRNAs that are delivered to synapses where proteins are locally synthesized. This last mechanism is known as local translation.
Aida de la Cruz-Gambra, Aida de la Cruz-Gambra, Jimena Baleriola, Jimena Baleriola   +3 more
doaj   +1 more source

A Mathematical Modeling of Infrared Neural Stimulation

Undergraduate Journal of Mathematical Modeling: One + Two, 2020
Electrical stimulation is the gold standard for artificial neural stimulation. The greatest disadvantage with electrical stimulation is that it scatters in space and it is difficult to achieve specific point stimulation.
Cesil S. Alex
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source