Results 21 to 30 of about 180,995 (352)

Neuropathic pain treatment: still a challenge

Neurology International, 2016
Neuropathic pain (NP) is the result of a series of conditions caused by diseases or lesions to the somatosensory system. Due to the better understanding of NP pathophysiology previously unexplored therapies have been used with encouraging results.
Osvaldo J.M. Nascimento, Bruno L. Pessoa, Marco Orsini, Pedro Ribeiro, Eduardo Davidovich, Camila Pupe, Pedro Moreira Filho, Ricardo Menezes Dornas, Lucas Masiero, Juliana Bittencourt, Victor Hugo Bastos   +10 more
doaj   +1 more source

Neuropathic pain and psychological morbidity in patients with treated leprosy: a cross-sectional prevalence study in Mumbai. [PDF]

PLoS Neglected Tropical Diseases, 2011
BACKGROUND: Neuropathic pain has been little studied in leprosy. We assessed the prevalence and clinical characteristics of neuropathic pain and the validity of the Douleur Neuropathique 4 questionnaire as a screening tool for neuropathic pain in ...
Estrella Lasry-Levy, Aki Hietaharju, Vivek Pai, Ramaswamy Ganapati, Andrew S C Rice, Maija Haanpää, Diana N J Lockwood   +6 more
doaj   +1 more source

Multimodal Stepped Care Approach Involving Topical Analgesics for Severe Intractable Neuropathic Pain in CRPS Type 1: A Case Report

Case Reports in Medicine, 2011
A multimodal stepped care approach has been successfully applied to a patient with complex regional pain syndrome type 1 and severe intractable pain, not responding to regular neuropathic pain medication. The choice to administer drugs in creams was made
David J. Kopsky, Jan M. Keppel Hesselink
doaj   +1 more source

Immune or genetic-mediated disruption of CASPR2 causes pain hypersensitivity due to enhanced primary afferent excitability [PDF]

, 2018
Human autoantibodies to contactin-associated protein-like 2 (CASPR2) are often associated with neuropathic pain, and CASPR2 mutations have been linked to autism spectrum disorders, in which sensory dysfunction is increasingly recognized.
Bennett, David L., Buckley, Camilla, Carroll, Liam, Cervellini, Ilaria, Chisholm, Kim I., Clark, Alex J, Coutinho, Ester, Dawes, John M., Dickenson, Anthony H., Galino, Jorge, Giannoccaro, Maria Pia, Gutierrez-Mecinas, Maria, Iwagaki, Noboru, Jacobson, Leslie, Kuehn, Hannah, Kühnemund, Johannes, Lang, Bethan, Leite, M Isabel, Lewin, Gary R., McMahon, Stephen B., Menassa, David A., Middleton, Steven J., Patel, Ryan, Peck, Liam J., Peles, Elior, Pettingill, Philippa, Sanna, Maria D., Shakir, Akila, Sheridan, Joseph, Tewari, Damini, Themistocleous, Andreas C., Todd, Andrew J., Trendafilova, Teodora, Vincent, Angela, Walcher, Jan, Weir, Greg A., Werynska, Karolina, West, Steven J., Wildner, Hendrik, Zeilhofer, Hanns Ulrich   +39 more
core   +2 more sources

Antinociceptive activity of the S1P-receptor agonist FTY720 [PDF]

, 2008
FTY720 is a novel immunosuppressive drug that inhibits the egress of lymphocytes from secondary lymphoid tissues and thymus. In its phosphorylated form FTY720 is a potent S1P receptor agonist.
Angioni, Carlo Federico, Brenneis, Christian, Coste, Ovidiu, Geisslinger, Gerd, Marian, Claudiu, Pierre, Sandra, Popp, Laura, Schmidt, Helmut, Scholich, Klaus   +8 more
core   +1 more source

Mechanisms of Neuropathic Pain [PDF]

Neuron, 2006
Neuropathic pain refers to pain that originates from pathology of the nervous system. Diabetes, infection (herpes zoster), nerve compression, nerve trauma, "channelopathies," and autoimmune disease are examples of diseases that may cause neuropathic pain. The development of both animal models and newer pharmacological strategies has led to an explosion
Richard A. Meyer, James N. Campbell
openaire   +3 more sources

Walking with Neuropathic Pain: Paradoxical Shift from Burden to Support?

Case Reports in Medicine, 2015
Baclofen 5% cream can be used for the treatment of neuropathic pain. We describe an unusual case of a neuropathic pain patient with spinal cord injury.
David J. Kopsky, Jan M. Keppel Hesselink, Roberto Casale   +2 more
doaj   +1 more source

Neuropathic pain in leprosy: symptom profile characterization and comparison with neuropathic pain of other etiologies

PAIN Reports, 2018
. Introduction:. Previous studies reported a high prevalence of neuropathic pain in leprosy, being especially present in “pharmacologically cured” patients.
Irina Raicher, Patrick Raymond Nicolas Andre Ghislain Stump, Simone Bega Harnik, Rodrigo Alves de Oliveira, Rosemari Baccarelli, Lucia H.S.C. Marciano, Somei Ura, Marcos C.L. Virmond, Manoel Jacobsen Teixeira, Daniel Ciampi de Andrade   +9 more
doaj   +1 more source

Oxcarbazepine for neuropathic pain [PDF]

Cochrane Database of Systematic Reviews, 2013
Neuropathic pain is difficult to treat. Oxcarbazepine is an anticonvulsant drug closely related to carbamazepine and is reportedly better tolerated. Oxcarbazepine has been reported to be efficacious in the treatment of neuropathic pain.To determine the benefits and harms of oxcarbazepine for different forms of neuropathic pain.We searched the Cochrane ...
Muke Zhou, Cairong Zhu, Ning Chen, Mi Yang, Fengbo Wu, Li He   +5 more
openaire   +3 more sources

NGX-4010, a capsaicin 8% patch, for the treatment of painful HIV-associated distal sensory polyneuropathy: integrated analysis of two phase III, randomized, controlled trials [PDF]

, 2013
BACKGROUND HIV-associated distal sensory polyneuropathy (HIV-DSP) is the most frequently reported neurologic complication associated with HIV infection.
Brew, Bruce J, Brown, Stephen, Fisher, Martin, Larbalestier, Nicholas, Moyle, Graeme, Orkin, Chloe, Schifitto, Giovanni, Simpson, David M, Tobias, Jeffrey K, Vanhove, Geertrui F   +9 more
core   +1 more source