Results 21 to 30 of about 69,136 (185)

Hyperpolarization Modulation of the T‐Type hCav3.2 Channel by Human Synenkephalin [1–53], a Shrew Neurotoxin Analogue without Paralytic Effects

Angewandte Chemie, EarlyView.
Human synenkephalin [1–53] (hSYN), an analogue peptide of shrew saliva neurotoxins, was synthesized and its structural characteristics studied. Synthetic hSYN potently activated the T‐type voltage‐gated Ca channel hCav3.2 but did not paralyze mealworms. These findings offer new insight into neurological disorder treatment and evolutionary mechanisms of
Ryo Fukuoka, Yusuke Yano, Nozomi Hara, Chihiro Sadamoto, Andres D. Maturana, Masaki Kita   +5 more
wiley   +2 more sources

Renal neuroendocrine control of desiccation and cold tolerance by Drosophila suzukii [PDF]

, 2017
Background: Neuropeptides are central to the regulation of physiological, and behavioural processes in insects, directly impacting cold and desiccation survival.
Al-Anzi, Asplen, Atallah, Audsley, Cabrero, Cabrero, Cannell, Choi, Chown, Cini, Coast, Coast, Condon, Dalton, David, Davies, Denlinger, Dow, Dow, Enriquez, Gerken, Gibbs, Goodhue, Hadley, Halberg, Hoffmann, Hoffmann, Huey, Jakobs, Jakobs, Jensen, Kacar, Kahsai, Kang, Kean, Kelty, Li, Matsumura, Matzkin, McWilliam, Nässel, O'Donnell, Plantamp, Poyet, Rajpurohit, Ryan, Schiffer, Schooley, Shearer, Sinclair, Sinclair, Sinclair, Stephens, Sørensen, Taghert, Telonis-Scott, Terblanche, Terhzaz, Terhzaz, Terhzaz, Tochen, Toxopeus, Wallingford, Yeoh   +63 more
core   +2 more sources

Chromosome‐Level Genome Assembly of the Leafcutter Bee Megachile rotundata Reveals Its Ecological Adaptation and Pollination Biology

Advanced Science, EarlyView.
The genome of Megachile rotundata, an extensively managed solitary pollination bee species, has been sequenced, covering 280.68 Mb and predicting 10 701 genes. The study reveals significant expansions of the Toll gene family and their abundant expression in diapause prepupae, highlighting enhanced immune responses during diapause. This genome serves as
Rangjun Shi, Pan Duan, Mengmeng Zhu, Rong Zhang, Zihua Zhao, Xin Nie, Hanhou He, Li Hou, Xianhui Wang   +8 more
wiley   +1 more source

Nezara viridula (Hemiptera: Pentatomidae) transcriptomic analysis and neuropeptidomics [PDF]

, 2018
Stinkbugs (Hemiptera: Pentatomidae) are of major economic importance as pest of crops. Among the species composing the stinkbug complex, Nezara viridula is one of the most abundant in Brazil, Argentina and the Southern USA. However, this species has been
Catalano, María Inés, Esponda Behrens, Natalia Irene, Lavore, Andres Esteban, Ons, Sheila, Palacio, Victorio Gabriel, Pérez Gianmarco, Lucila Maité, Rivera Pomar, Rolando   +6 more
core   +2 more sources

Semaphorin 3E‐Plexin‐D1 Pathway Downstream of the Luteinizing Hormone Surge Regulates Ovulation, Granulosa Cell Luteinization, and Ovarian Angiogenesis in Mice

Advanced Science, EarlyView.
The Semaphorin 3E (Sema3E)‐Plexin‐D1 pathway mediated by C/EBPα and C/EBPβ downstream of the luteinizing hormone (LH) surge plays important roles in the mouse preovulatory ovary. Timely activation and suppression of this pathway during the preovulatory stage are crucial for ovulation, corpus luteum formation, and proper angiogenesis.
Hanxue Zhang, Jimmy Dhillon, Paul D. Soloway, Bo Shui, Seoyeon Lee, Jennifer K. Grenier, Paul R. Munn, M. Cecilia Ljungberg, Rebecca B Williams, Rainer B. Lanz, Yu‐Hsiang Liao, Yi A. Ren   +11 more
wiley   +1 more source

Neuropeptides in tendinopathy [PDF]

Frontiers in Bioscience, 2009
Overuse tendinopathy remains a major clinical burden for sports medicine and general practitioners. Recent studies have highlighted the role of sensory and autonomic nerves in generating or perpetuating the symptoms and tissue abnormalities associated with tendinopathy.
Roald Bahr, Alex Scott
openaire   +3 more sources

Oxytocin‐Mediate Modulation of Splenic Immunosuppression in Chronic Social Stress Through Neuroendocrine Pathways

Advanced Science, EarlyView.
Chronic social stress elevates oxytocin levels, leading to immunosuppression by enhancing regulatory T‐cell activity and promoting anti‐inflammatory macrophage polarization in the spleen. Blocking oxytocin signaling reverses these effects but worsens stress‐induced behavioral disorders and reduces survival rates. This highlights oxytocin's dual role in
Yi‐Shu Zhang, Hai‐Chao Chen, Jia‐Xin Cao, Si‐Wei Zhou, Yue‐Zhang Ma, Yu‐Hong Jing   +5 more
wiley   +1 more source

Allatostatin-A neurons inhibit feeding behavior in adult Drosophila [PDF]

, 2012
How the brain translates changes in internal metabolic state or perceived food quality into alterations in feeding behavior remains poorly understood.
Anderson, David J., Hergarden, Anne Christina, Tayler, Timothy D.   +2 more
core   +2 more sources

Neuropeptide S [PDF]

Neuron, 2004
Arousal and anxiety are behavioral responses that involve complex neurocircuitries and multiple neurochemical components. Here, we report that a neuropeptide, neuropeptide S (NPS), potently modulates wakefulness and could also regulate anxiety. NPS acts by activating its cognate receptor (NPSR) and inducing mobilization of intracellular Ca2+.
Luis de Lecea, Yan Ling Xu, Zhiwei Wang, Rainer K. Reinscheid, Steven H.S. Lin, Nga Kim Ly, Steven J. Henriksen, Olivier Civelli, Stewart D. Clark, Fernando A. Brucher, Salvador Huitron-Resendiz, Joanne Zeng   +11 more
openaire   +3 more sources

In Vivo Cytosolic Delivery of Biomolecules into Neurons for Super‐Resolution Imaging and Genome Modification

Advanced Science, EarlyView.
The N1 peptide specifically targets neurons, enabling cytosolic delivery of fluorescent dyes and proteins for super‐resolution imaging and functional genetic modification. Abstract Efficient delivery of biomolecules into neurons has significant impacts on therapeutic applications in the central nervous system (CNS) and fundamental neuroscience research.
Xiaoqian Ge, Joseph B. Wekselblatt, Scott Elmore, Bo Wang, Tongtong Wang, Renjinming Dai, Tingting Zhang, Harsh Dave, Mohammadaref Ghaderi, Athul Raj Anilkumar, Bill Wang, Shashank R. Sirsi, Jung‐Mo Ahn, Mikhail G. Shapiro, Yuki Oka, Carlos Lois, Zhenpeng Qin   +16 more
wiley   +1 more source