Results 91 to 100 of about 206,368 (387)

Neuropeptide Y and Y1 Receptors in Kindling Epileptogenesis [PDF]

Epilepsy Currents, 2004
Neuropeptide Y (NPY)-mediated neurotransmission undergoes plastic changes during hippocampal or amygdaloid kindling in rats as shown by changes in peptide cellular expression and distribution, its release and receptor subtype plasticity (for review see 37, 51). Electrophysiological and pharmacological evidence in in vitro and in vivo models of seizures
openaire   +3 more sources

Chicken neuropeptide Y-family receptor Y4: a receptor with equal affinity for pancreatic polypeptide, neuropeptide Y and peptide YY [PDF]

Journal of Molecular Endocrinology, 2002
Within the neuropeptide Y (NPY) family of peptides, pancreatic polypeptide is the most divergent across species. It differs in 20 of 36 positions between human and chicken. In mammals, it binds primarily to the Y4 receptor, to which NPY and peptide YY (PYY) bind with lower affinities.
Ingrid Lundell, Dan Larhammar, Timothy Boswell   +2 more
openaire   +4 more sources

Targeted Proteomics upon Treatment with Tofersen Identifies Novel Response Markers for Superoxide Dismutase 1‐Linked Amyotrophic Lateral Sclerosis

Annals of Neurology, EarlyView.
Objective Tofersen is the first effective and approved therapy for superoxide dismutase 1 (SOD1)‐associated amyotrophic lateral sclerosis (ALS [SOD1‐ALS]). Following treatment with tofersen, neurofilament levels in patients' cerebrospinal fluid (CSF) and serum seem to respond earlier than clinical parameters.
Christina Steffke, Karthik Baskar, Franziska Bachhuber, Maximilian Wiesenfarth, Johannes Dorst, Joachim Schuster, Florian Schöberl, Peter Reilich, Martin Regensburger, Alexander German, René Günther, Maximilian Vidovic, Susanne Petri, Thomas Meyer, Tim Hagenacker, Julian Grosskreutz, Ute Weyen, Patrick Weydt, Thomas Haarmeier, Paul Lingor, Joachim Wolf, Andreas Hermann, Johannes Prudlo, Kornelia Günther, Antje Knehr, Zeynep Elmas, Zeljko Uzelac, Simon Witzel, Wolfgang Philipp Ruf, Axel Freischmidt, Ritchie Ho, Albert C. Ludolph, Jochen H. Weishaupt, Hayrettin Tumani, Patrick Oeckl, David Brenner, Alberto Catanese   +36 more
wiley   +1 more source

Y1 and Y5 receptors are both required for the regulation of food intake and energy homeostasis in mice. [PDF]

PLoS ONE, 2012
Neuropeptide Y (NPY) acting in the hypothalamus is one of the most powerful orexigenic agents known. Of the five known Y receptors, hypothalamic Y1 and Y5 have been most strongly implicated in mediating hyperphagic effects.
Amy D Nguyen, Natalie F Mitchell, Shu Lin, Laurence Macia, Ernie Yulyaningsih, Paul A Baldock, Ronaldo F Enriquez, Lei Zhang, Yan-Chuan Shi, Serge Zolotukhin, Herbert Herzog, Amanda Sainsbury   +11 more
doaj   +1 more source

Serotonin mediated changes in corticotropin releasing factor mRNA expression and feeding behavior isolated to the hypothalamic paraventricular nuclei [PDF]

, 2011
Fenfluramine reduces hunger and promotes body weight loss by increasing central serotonin (5-HT) signaling. More recently, neuropeptides have been linked to the regulation of feeding behavior, metabolism and body weight.
Boisvert, Joanne P, Boschuetz, Tyler J., Choi, Sujean, Mueller, Christopher R, Resch, Jon M   +4 more
core   +2 more sources

Expression of neuropeptide Y receptors in human prostate cancer cells.

Annals of Oncology, 2001
BACKGROUND Neuroendocrine molecules are now believed to play a significant role in the progression of human prostate cancer (CaP), especially in the androgen-independent stage.
Paolo Magni, Marcella Motta
semanticscholar   +1 more source

Regulation of Neurotransmission in the Arcuate Nucleus of the Rat by Different Neuropeptide Y Receptors

Journal of Neuroscience, 1997
We examined the effects of peptides of the neuropeptide Y (NPY)/pancreatic polypeptide (PP) family on synaptic transmission in the arcuate nucleus in rat hypothalamic slices. Application of NPY produced two effects.
Hyewhon Rhim, G. Kinney, P. Emmerson, Richard J. Miller   +3 more
semanticscholar   +1 more source

Regulatory Role of FGL‐1 in Interorgan Communication by Controlling T Cell Homeostasis During the Onset of Sjögren Disease

Arthritis &Rheumatology, EarlyView.
Objective Autoimmunity occurs due to the tactics between pathogenic and regulatory factors in systemic organs. Although interorgan communication has been demonstrated in various diseases, the effects of the crosstalk between the immune system and other organs on autoimmune disease is unknown.
Kunihiro Otsuka, Aya Ushio, Ruka Nagao, Shigefumi Matsuzawa, Rieko Arakaki, Kazuki Fukuta, Yasuhiro Mouri, Takaaki Tsunematsu, Naozumi Ishimaru   +8 more
wiley   +1 more source

The Role of Neuropeptide Y in Cardiovascular Health and Disease

Frontiers in Physiology, 2018
Neuropeptide Y (NPY) is an abundant sympathetic co-transmitter, widely found in the central and peripheral nervous systems and with diverse roles in multiple physiological processes.
Cheryl M. J. Tan, Peregrine Green, Nidi Tapoulal, Adam J. Lewandowski, Paul Leeson, Neil Herring   +5 more
doaj   +1 more source

Structural analysis of the starfish SALMFamide neuropeptides S1 and S2: The N-terminal region of S2 facilitates self-association [PDF]

, 2014
The neuropeptides S1 (GFNSALMFamide) and S2 (SGPYSFNSGLTFamide), which share sequence similarity, were discovered in the starfish Asterias rubens and are prototypical members of the SALMFamide family of neuropeptides in echinoderms.
Bader, Cavanagh, Chassaing, Christopher E. Jones, Cierpicki, Claire B. Otara, Cowsik, Edison, Elphick, Elphick, Elphick, Elphick, Elphick, Feeney, Fontenot, Grace, Grace, Greenfield, Inooka, John H. Viles, Keire, Ma, Maurice R. Elphick, Melarange, Melarange, Nadine D. Younan, Newman, Newman, Nieto, Rowe, Sumner, Wuthrich, Xu   +32 more
core   +1 more source