The gender-specific expression of neuropeptide Y and neuropeptide Y receptors in human atrial tissue during cardiopulmonary bypass surgery. [PDF]
Meng F+5 more
europepmc +1 more source
From gonadotropin-inhibitory hormone to SIFamides: Are echinoderm SALMFamides the "missing link" in a bilaterian family of neuropeptides that regulate reproductive processes? [PDF]
Bentley+46 more
core +1 more source
Contribution of perineuronal nets to hyperexcitability in pilocarpine‐induced status epilepticus
Abstract Objective Changes in extracellular matrix (ECM) and highly condensed ECM structures called perineuronal nets (PNNs) have been reported in human patients with epilepsy as well as some animal models of epilepsy. We studied potential ECM changes in a mouse model of pilocarpine‐induced status epilepticus (PISE) and their potential contributions to
AnnaLin M. Woo+3 more
wiley +1 more source
Abstract Objective Mutations of the DEP Domain Containing 5 gene (DEPDC5), a mechanistic Target of Rapamycin (mTOR) inhibitor involved in amino acid sensing, are associated with neurological diseases such as epilepsy and/or autism spectrum disorder (ASD). Loss of DEPDC5 impacts early neuronal development via mTOR hyperactivity.
Mattson S. O. Jones+14 more
wiley +1 more source
Neuropeptide Y (NPY) as a therapeutic target for neurodegenerative diseases
Neuropeptide Y (NPY) and NPY receptors are widely expressed in the mammalian central nervous system. Studies in both humans and rodent models revealed that brain NPY levels are altered in some neurodegenerative disorders, such as Alzheimer's disease ...
Joana Duarte-Neves+2 more
doaj
Role of sulfhydryl groups in Y2 neuropeptide Y receptor binding activity.
W Li+2 more
openalex +1 more source
Chronic Blockade of the Melanocortin 4 Receptor Subtype Leads to Obesity Independently of Neuropeptide Y Action, with No Adverse Effects on the Gonadotropic and Somatotropic Axes**This work was supported by grants from the Swiss National Research Science Foundation (31–39729-93, 31–55732-98, and 32–04912 3–97) and in part by Ferring Pharmaceuticals Ltd. Research Laboratories. [PDF]
Paula Raposinho+5 more
openalex +1 more source
Osteochondrosis in horses: An overview of genetic and other factors
Abstract Osteochondrosis (OC) is a frequent manifestation of developmental orthopaedic disease, and its severe clinical presentation is known as OC dissecans (OCD). OC is defined as a disruption of the endochondral ossification process in the epiphyseal cartilage, and this disease has been reported in different mammalian species, including humans, dogs,
Lola Martinez‐Saez+2 more
wiley +1 more source