Results 11 to 20 of about 72,976 (300)
Characterization of vascular neuropeptide Y receptors [PDF]
British Journal of Pharmacology, 1992 In the present study we compared neuropeptide Y (NPY) and NPY‐related analogues for their ability to activate or bind to vascular NPY receptors in four experimental set‐ups. Previous results have suggested the existence of different receptor subtypes, Y1 receptors requiring full‐length NPY (1–36) or [Pro34]‐NPY, and Y2 receptors recognizing also N ...
L, Grundemar +5 more
openaire +4 more sources
Structural basis for ligand recognition of the neuropeptide Y Y2 receptor
Nature Communications, 2021 The human neuropeptide Y receptor Y2 (Y2R) is a drug target for the treatment of obesity and anxiety. Crystal structure of Y2R bound to a selective antagonist and accompanying mutagenesis provide insights into ligand recognition and subtype specificity ...
Tingting Tang +13 more
doaj +1 more source
Neurobiology of Disease, 2012 We recently demonstrated that recombinant adeno-associated viral vector-induced hippocampal overexpression of neuropeptide Y receptor, Y2, exerts a seizure-suppressant effect in kindling and kainate-induced models of epilepsy in rats.
Casper R. Gøtzsche +8 more
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Nezara viridula (Hemiptera: Pentatomidae) transcriptomic analysis and neuropeptidomics [PDF]
, 2018 Stinkbugs (Hemiptera: Pentatomidae) are of major economic importance as pest of crops. Among the species composing the stinkbug complex, Nezara viridula is one of the most abundant in Brazil, Argentina and the Southern USA. However, this species has been
Catalano, María Inés +6 more
core +2 more sources
The evolution and variety of RFamide-type neuropeptides: insights from deuterostomian invertebrates [PDF]
, 2014 Five families of neuropeptides that have a C-terminal RFamide motif have been identified in vertebrates: (1) gonadotropin-inhibitory hormone (GnIH), (2) neuropeptide FF (NPFF), (3) pyroglutamylated RFamide peptide (QRFP), (4) prolactin-releasing peptide (
Elphick, MR, Mirabeau, O
core +1 more source
A Promising Therapeutic Target for Metabolic Diseases: Neuropeptide Y Receptors in Humans
Cellular Physiology and Biochemistry, 2017 Human neuropeptide Y (hNPY) is one of the most widely expressed neurotransmitters in the human central and peripheral nervous systems. It consists of 36 highly conserved amino acid residues, and was first isolated from the porcine hypothalamus in 1982 ...
Min Yi +6 more
doaj +1 more source
Structural basis of neuropeptide Y signaling through Y1 receptor
Nature Communications, 2022 The human neuropeptide Y (NPY) acts through G-protein coupled receptors and is involved in food intake, stress response, anxiety, and memory retention.
Chaehee Park +12 more
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Frontiers in Neural Circuits, 2022 Neuropeptides, a diverse class of signaling molecules in the nervous system, modulate various biological effects including membrane excitability, synaptic transmission and synaptogenesis, gene expression, and glial cell architecture and function. To date,
Sanne M. Casello +9 more
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Identification of neuropeptides and neuropeptide receptor genes in Phauda flammans (Walker)
Scientific Reports, 2022 Neuropeptides and neuropeptide receptors are crucial regulators to insect physiological processes. The 21.0 Gb bases were obtained from Illumina sequencing of two libraries representing the female and male heads of Phauda flammans (Walker) (Lepidoptera ...
Hai-Pan Wu +5 more
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The Role of NPY in the Regulation of Bone Metabolism
Frontiers in Endocrinology, 2022 Bone diseases are the leading causes of disability and severely compromised quality of life. Neuropeptide Y (NPY) is a multifunctional neuropeptide that participates in various physiological and pathological processes and exists in both the nerve system ...
Qing-Chang Chen +2 more
doaj +1 more source