Results 11 to 20 of about 21,634,263 (295)

Evolution of neuropeptide Y/RFamide-like receptors in nematodes

Heliyon
The Neuropeptide Y/RFamide-like receptors belong to the Rhodopsin-like G protein-coupled receptors G protein-coupled receptors (GPCRs) and are involved in functions such as locomotion, feeding and reproduction.
Franziska Reinhardt, Anette Kaiser, Simone Prömel, Peter F. Stadler   +3 more
doaj   +4 more sources

Neuropeptide Y receptors: How to get subtype selectivity [PDF]

Frontiers in Endocrinology, 2013
The neuropeptide Y system is a multireceptor/multiligand system consisting of four receptors in humans (hY1, hY2, hY4, hY5) and three agonists (NPY, PYY, PP) that activate these receptors with different potency.
Xavier ePedragosa Badia, Jan eStichel, Annette G Beck-Sickinger   +2 more
doaj   +2 more sources

Sympathetic nervous system catecholamines and neuropeptide Y neurotransmitters are upregulated in human NAFLD and modulate the fibrogenic function of hepatic stellate cells. [PDF]

PLoS ONE, 2013
Sympathetic nervous system (SNS) signalling regulates murine hepatic fibrogenesis through effects on hepatic stellate cells (HSC), and obesity-related hypertension with SNS activation accelerates progression of non-alcoholic fatty liver disease (NAFLD ...
Barbara Sigala, Chad McKee, Junpei Soeda, Valerio Pazienza, Maelle Morgan, Ching-I Lin, Clare Selden, Sara Vander Borght, Gianluigi Mazzoccoli, Tania Roskams, Manlio Vinciguerra, Jude A Oben   +11 more
doaj   +3 more sources

Characterization of vascular neuropeptide Y receptors [PDF]

British Journal of Pharmacology, 1992
In the present study we compared neuropeptide Y (NPY) and NPY‐related analogues for their ability to activate or bind to vascular NPY receptors in four experimental set‐ups. Previous results have suggested the existence of different receptor subtypes, Y1 receptors requiring full‐length NPY (1–36) or [Pro34]‐NPY, and Y2 receptors recognizing also N ...
Edward D Högestätt, Claes Wahlestedt, Rolf Håkanson   +2 more
exaly   +3 more sources

New antagonist agents of neuropeptide y receptors [PDF]

Química Nova, 2000
In the CNS, NPY has been implicated in obesity and feeding, endocrine function and metabolism. Potent and selective rNPY antagonists will be able to probe the merits of this approach for the treatment of obesity.
Ignacio Aldana, Isabel Rivero, Argimiro Rivero, Patricio Huenchuñir, Carmen Frigola, Maria Luisa Alonso, Antonio Monge, D. H. Caignard, P. Renard   +8 more
doaj   +5 more sources

Heterobivalent Dual-Target Peptide for Integrin-α_vβ₃ and Neuropeptide Y Receptors on Breast Tumor [PDF]

Pharmaceuticals
Background/Objectives: Heterodimer peptides targeting more than one receptor can be advantageous, as tumors can simultaneously express more than one receptor type.
Aryel H. Ferreira, Caroline C. Real, Osvaldo Malafaia   +2 more
doaj   +2 more sources

Empowering exhausted T cells of Glioblastoma patients by Neurotransmitters and Neuropeptides: decreasing immune checkpoint inhibitors, and increasing CD3zeta, proliferation and Glioblastoma arrest [PDF]

Cancer Immunology, Immunotherapy
Background Glioblastoma is the most common malignant brain tumor, with extremely poor prognosis, and patient’s T cells are exhausted, dysfunctional, and unable to eliminate Glioblastoma.
Mia Levite, Nili Ilouz, Eithan Galun, Yigal Shoshan   +3 more
doaj   +2 more sources

Development of neuropeptide Y-ergic innervation of the small intestine in rats

Учёные записки Казанского университета: Серия Естественные науки, 2018
Neuropeptide Y (NPY) acts as a neurotransmitter in the autonomic nervous system, including in the metasympathetic intramural ganglia of the intestine.
P.M. Masliukov, J.P. Timmermans, A.A. Zverev, T.L. Zefirov   +3 more
doaj   +1 more source

Neuropeptide Y receptors: a promising target for cancer imaging and therapy. [PDF]

Regen Biomater, 2015
Neuropeptide Y (NPY) was first identified from porcine brain in 1982, and plays its biological functions in humans through NPY receptors (Y1, Y2, Y4 and Y5).
Li J, Tian Y, Wu A.
europepmc   +2 more sources

Unusually persistent Gαi-signaling of the neuropeptide Y2 receptor depletes cellular Gi/o pools and leads to a Gi-refractory state

Cell Communication and Signaling, 2020
Background A sensitive balance between receptor activation and desensitization is crucial for cellular homeostasis. Like many other GPCR, the human neuropeptide Y2 receptor (hY2R) undergoes ligand dependent activation and internalization into ...
Isabelle Ziffert, Anette Kaiser, Stefanie Babilon, Karin Mörl, Annette G. Beck-Sickinger   +4 more
doaj   +1 more source