Results 21 to 30 of about 21,634,263 (295)

PET Imaging of the Neuropeptide Y System: A Systematic Review

Molecules, 2022
Neuropeptide Y (NPY) is a vastly studied biological peptide with numerous physiological functions that activate the NPY receptor family (Y1, Y2, Y4 and Y5).
Inês C. F. Fonseca, Miguel Castelo-Branco, Cláudia Cavadas, Antero J. Abrunhosa   +3 more
doaj   +1 more source

Effects of neuropeptide Y on electrical activity and myocardial contractility

Учёные записки Казанского университета: Серия Естественные науки, 2018
Neuropeptide Y (NPY) and agonist Leu(31)Pro(34)NPY were used to determine the type of NPY receptors involved in electrical activity and myocardial contraction.
A.A. Zverev, T.A. Anikina, N.G. Iskakov, A.V. Krulova, P.M. Masliukov, J.P. Timmermans, T.L. Zefirov   +6 more
doaj   +1 more source

Neuropeptide Y receptors in GtoPdb v.2023.1 [PDF]

, 2023
Neuropeptide Y (NPY) receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Neuropeptide Y Receptors [158]) are activated by the endogenous peptides neuropeptide Y, neuropeptide Y-(3-36), peptide YY, PYY-(3-36) and pancreatic polypeptide (PP).
Cox, Helen M., Thue Schwartz, Dan Larhammar, Helen M. Cox, Beck-Sickinger, Annette G., Herzog, Herbert, Thomas Westfall, Michel, Martin C., Larhammar, Dan, Westfall, Thomas, Martin C. Michel, Remi Quirion, Schwartz, Thue, William F. Colmers, Henri N. Doods, Doods, Henri N., Quirion, Remi, Colmers, William F., Annette G. Beck-Sickinger, Herbert Herzog   +19 more
core   +1 more source

Structural basis for ligand recognition of the neuropeptide Y Y2 receptor

Nature Communications, 2021
The human neuropeptide Y receptor Y2 (Y2R) is a drug target for the treatment of obesity and anxiety. Crystal structure of Y2R bound to a selective antagonist and accompanying mutagenesis provide insights into ligand recognition and subtype specificity ...
Tingting Tang, Christin Hartig, Qiuru Chen, Wenli Zhao, Anette Kaiser, Xuefeng Zhang, Hui Zhang, Honge Qu, Cuiying Yi, Limin Ma, Shuo Han, Qiang Zhao, Annette G. Beck-Sickinger, Beili Wu   +13 more
doaj   +1 more source

Echinoderms provide missing link in the evolution of PrRP/sNPF-type neuropeptide signalling

eLife, 2020
Neuropeptide signalling systems comprising peptide ligands and cognate receptors are evolutionarily ancient regulators of physiology and behaviour.
Luis Alfonso Yañez-Guerra, Xingxing Zhong, Ismail Moghul, Thomas Butts, Cleidiane G Zampronio, Alexandra M Jones, Olivier Mirabeau, Maurice R Elphick   +7 more
doaj   +1 more source

Differential Changes in Expression of Stress- and Metabolic-related Neuropeptides in the Rat Hypothalamus during Morphine Dependence and Withdrawal [PDF]

, 2013
Chronic morphine treatment and naloxone precipitated morphine withdrawal activates stress-related brain circuit and results in significant changes in food intake, body weight gain and energy metabolism.
Nunez, Cristina, Edina Zelei, M Victoria Milanés, Polyák, Ágnes, Zelei, Edina, Agnes Polyák, Krisztina J Kovács, Kovács, Krisztina J., Cristina Núnez, Milanes, Victoria M., Pintér-Kübler, Bernadett, Ferenczi, Szilamér, Bernadett Pintér-Kübler, Szilamér Ferenczi   +13 more
core   +3 more sources

Combined gene overexpression of neuropeptide Y and its receptor Y5 in the hippocampus suppresses seizures

Neurobiology of Disease, 2012
We recently demonstrated that recombinant adeno-associated viral vector-induced hippocampal overexpression of neuropeptide Y receptor, Y2, exerts a seizure-suppressant effect in kindling and kainate-induced models of epilepsy in rats.
Casper R. Gøtzsche, Litsa Nikitidou, Andreas T. Sørensen, Mikkel V. Olesen, Gunnar Sørensen, Søren H.O. Christiansen, Mikael Ängehagen, David P.D. Woldbye, Merab Kokaia   +8 more
doaj   +1 more source

Ligands of the neuropeptide Y Y2 receptor [PDF]

Bioorganic & Medicinal Chemistry Letters, 2014
Neuropeptide Y (NPY) is one of the most abundant neuropeptides in the mammalian brain and exerts a variety of physiological processes in humans via four different receptor subtypes Y1, Y2, Y4 and Y5. Y2 receptor is the most abundant Y subtype receptor in the central nervous system and implicated with food intake, bone formation, affective disorders ...
Gopi Kumar, Mittapalli, Edward, Roberts
openaire   +2 more sources

A Promising Therapeutic Target for Metabolic Diseases: Neuropeptide Y Receptors in Humans

Cellular Physiology and Biochemistry, 2017
Human neuropeptide Y (hNPY) is one of the most widely expressed neurotransmitters in the human central and peripheral nervous systems. It consists of 36 highly conserved amino acid residues, and was first isolated from the porcine hypothalamus in 1982 ...
Min Yi, Hekai Li, Zhiye Wu, Jianyun Yan, Qicai Liu, Caiwen Ou, Minsheng Chen   +6 more
doaj   +1 more source

Structural basis of neuropeptide Y signaling through Y1 receptor

Nature Communications, 2022
The human neuropeptide Y (NPY) acts through G-protein coupled receptors and is involved in food intake, stress response, anxiety, and memory retention.
Chaehee Park, Jinuk Kim, Seung-Bum Ko, Yeol Kyo Choi, Hyeongseop Jeong, Hyeonuk Woo, Hyunook Kang, Injin Bang, Sang Ah Kim, Tae-Young Yoon, Chaok Seok, Wonpil Im, Hee-Jung Choi   +12 more
doaj   +1 more source