Results 41 to 50 of about 21,634,263 (295)
Scientific Reports, 2021 Neuropeptides function through G protein-coupled receptors (GPCRs) with high specificity, implying a significant degree of neuropeptide-GPCR coevolution. However, potential neuropeptide signaling systems in non-chordates are relatively elusive.
Kyeong Seop Kim +3 more
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Investigations on neuropeptide Y and histamine receptors by fluorescence-based and radiochemical methods [PDF]
, 2011 In the last three decades, a large amount of experimental data (for example Förster resonance energy transfer (FRET) at fluorescently labelled receptors) supported the hypothesis of the dimerization of G-protein-coupled receptors (GPCR), including ...
Lopuch, Miroslaw
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PLoS Biology, 2020 The reproductive hormones that trigger oocyte meiotic maturation and release from the ovary vary greatly between animal species. Identification of receptors for these maturation-inducing hormones (MIHs) and understanding how they initiate the largely ...
Gonzalo Quiroga Artigas +8 more
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Y1 and Y2 receptors for neuropeptide Y [PDF]
FEBS Letters, 1989 By using monoiodinated radioligands of both intact neuropeptide Y (NPY) and of a long C‐terminal fragment, NPY13–36, two subtypes of binding sites, which differ in affinity and specificity, have been characterized. The Y1 type of binding site, characterized on a human neuroblastoma cell line, MC‐IXC, and a rat pheochromocytoma cell line, PC‐12, binds ...
Sheikh, Søren P. +2 more
openaire +2 more sources
Phylogenetic investigation of peptide hormone and growth factor receptors in five dipteran genomes
Frontiers in Endocrinology, 2013 Peptide hormones and growth factors bind to membrane receptors and regulate a myriad of processes in insects and other metazoans. The evolutionary relationships among characterized and un-characterized (orphan) receptors can provide insights into ...
Kevin J. Vogel +2 more
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Functional and genetic characterization of neuropeptide Y-like receptors in Aedes aegypti. [PDF]
PLoS Neglected Tropical Diseases, 2013 BACKGROUND:Female Aedes aegypti mosquitoes are the principal vector for dengue fever, causing 50-100 million infections per year, transmitted between human and mosquito by blood feeding. Ae.
Jeff Liesch +2 more
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
FEBS Open Bio, EarlyView.The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen +8 more
wiley +1 more source
Impact of Orexin-A Treatment on Food Intake, Energy Metabolism and Body Weight in Mice. [PDF]
PLoS ONE, 2017 Orexin-A and -B are hypothalamic neuropeptides of 33 and 28-amino acids, which regulate many homeostatic systems including sleep/wakefulness states, energy balance, energy homeostasis, reward seeking and drug addiction.
Anne Blais +6 more
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The Role of Calcitonin Gene‐Related Peptide in High‐Altitude Headache: A Prospective Field Study
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective High‐altitude headache (HAH) is a common neurological condition associated with rapid ascent to high altitude. The pathophysiological mechanisms underlying HAH remain incompletely understood. Calcitonin gene‐related peptide (CGRP), a neuropeptide implicated in migraine pathophysiology, may play a key role in the pathophysiology of ...
Roman Schniepp +4 more
wiley +1 more source