Results 61 to 70 of about 72,976 (300)

The direct response of the gonads to cues of stress in a temperate songbird species is season-dependent. [PDF]

, 2013
The gonadotropin releasing hormone (GnRH) system in the hypothalamus is often considered the final point in integration of environmental cues as they pertain to the reproductive axis.
Bentley, George, Koh, Annie, McGuire, Nicolette   +2 more
core   +2 more sources

Neuid: A Novel Neuron‐Enriched LncRNA that Connects Epigenetic Gene Silencing to Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT The increasing evidence that non‐coding RNAs can become deregulated during pathogenesis is dramatically expanding the space for drug discovery beyond the protein‐coding genome. Long noncoding RNAs (lncRNAs) are emerging as key regulators of cellular function, yet most remain uncharacterized.
Ranjit Pradhan, Zorica Petrovic, M. Sadman Sakib, Sophie Schröder, Dennis Manfred Krüger, Tonatiuh Pena, Eren Diniz, Susanne Burkhardt, Anna‐Lena Schütz, Verena Gisa, Iga Grzadzielewska, Karl Toischer, Thor D. Stein, Jan Krzysztof Blusztajn, Ivana Delalle, Jelena Radulovic, Farahnaz Sananbenesi, Andre Fischer   +17 more
wiley   +1 more source

Differential suppression of seizures via Y2 and Y5 neuropeptide Y receptors

Neurobiology of Disease, 2005
Neuropeptide Y (NPY) prominently inhibits epileptic seizures in different animal models. The NPY receptors mediating this effect remain controversial partially due to lack of highly selective agonists and antagonists.
David P.D. Woldbye, Avtandil Nanobashvili, Andreas T. Sørensen, Henriette Husum, Tom G. Bolwig, Gunnar Sørensen, Patrik Ernfors, Merab Kokaia   +7 more
doaj   +1 more source

Inhibition of Y1 receptor signaling improves islet transplant outcome [PDF]

, 2017
Failure to secrete sufficient quantities of insulin is a pathological feature of type-1 and type-2 diabetes, and also reduces the success of islet cell transplantation.
A Ali-Rachedi, A Thonpho, AD Nguyen, AG Nieuwenhuizen, AM Shapiro, AM Shapiro, American Diabetes, A., AR Saltiel, C Ammala, C Postic, C Ricordi, C Ricordi, CR Gustavsen, D Boey, D Boey, D Ize-Ludlow, DL Eizirik, DM Sousa, E Karra, G Bertrand, H Matsuda, H Yajima, HA Wieland, J Cantley, JM Sosenko, JY Kim, K Loh, K Yang, L Zhang, L Zhang, LA Selbie, M Jackerott, N Butta, O Idevall-Hagren, RA Stokes, RL Batterham, RP Robertson, S Kassis, S Seino, S Walters, T Yada, TL Belle van, TT Ngo, W Shao, Y Kashima, YC Shi, YC Shi   +46 more
core   +5 more sources

Functional Analysis of Ligand‐Gated Chloride Channels in a Cnidarian Sheds Light on the Evolution of Inhibitory Signaling

Advanced Science, EarlyView.
We uncover a large variety of putative inhibitory ligand‐gated ion channels (LGICs) in the phylum Cnidaria, the sister group to all bilaterian animals. Phylogenetic analysis suggests a complex evolutionary history of inhibitory LGICs with diverse neurotransmitter ligands.
Abhilasha Ojha, Linda Kloss, Juan D. Montenegro, Simone Albani, Audrey Ortega‐Ramírez, Mihaela Raycheva, Sylvia Joussen, Sabrina Kaul, Michèle Bachmann, Lisa Huf, Günther Schmalzing, Alison G. Cole, Ulrich Technau, Stefan Gründer   +13 more
wiley   +1 more source

Melanin-Concentrating Hormone (MCH): Role in REM Sleep and Depression. [PDF]

, 2015
The melanin-concentrating hormone (MCH) is a peptidergic neuromodulator synthesized by neurons of the lateral sector of the posterior hypothalamus and zona incerta.
Benedetto, Luciana, Chase, Michael H, Lagos, Patricia, López-Hill, Ximena, Monti, Jaime M, Pascovich, Claudia, Scorza, Cecilia, Torterolo, Pablo, Urbanavicius, Jessika   +8 more
core   +6 more sources

Factors associated with the development of dynapenia in patients with ulcerative colitis

Бюллетень сибирской медицины
Aim. To evaluate the association of insulin resistance and secretion of neuropeptide Y with dynapenia in patients with ulcerative colitis (UC). Materials and methods.
G. R. Bikbavova, M. A. Livzan, N. S. Lisyutenko, A. E. Romanyuk, A. A. Bondarenko   +4 more
doaj   +1 more source

Pharmacological and functional similarities of the human neuropeptide Y system in C. elegans challenges phylogenetic views on the FLP/NPR system

Cell Communication and Signaling, 2019
Background The neuropeptide Y system affects various processes, among others food intake, and is frequently discussed in the context of targeting obesity. Studies in model organisms are indispensable to enable molecular studies in a physiological context.
Miron Mikhailowitsch Gershkovich, Victoria Elisabeth Groß, Anette Kaiser, Simone Prömel   +3 more
doaj   +1 more source

Aging and aerobic fitness affect the contribution of noradrenergic sympathetic nerves to the rapid cutaneous vasodilator response to local heating [PDF]

, 2011
Sedentary aging results in a diminished rapid cutaneous vasodilator response to local heating. We investigated whether this diminished response was due to altered contributions of noradrenergic sympathetic nerves; assessing 1) the age-related decline and,
Alan D. Ruddock, Angus JA, Garry A. Tew, Gary J. Hodges, James Moss, John M. Saxton, Markos Klonizakis   +6 more
core   +1 more source

High-affinity neuropeptide Y receptor antagonists. [PDF]

Proceedings of the National Academy of Sciences, 1995
Neuropeptide Y (NPY) is one of the most abundant peptide transmitters in the mammalian brain. In the periphery it is costored and coreleased with norepinephrine from sympathetic nerve terminals. However, the physiological functions of this peptide remain unclear because of the absence of specific high-affinity receptor antagonists.
A J, Daniels, J E, Matthews, R J, Slepetis, M, Jansen, O H, Viveros, A, Tadepalli, W, Harrington, D, Heyer, A, Landavazo, J J, Leban, A, Spaltenstein   +10 more
openaire   +2 more sources